Pregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of Pregnancy
Resumen:
The objective was to evaluate the effects of pregnancy and bovine somatotropin (bST) on endometrial gene and protein expression related to maintenance of pregnancy in nonlactating dairy cows at d 17. In endometrial tissues, treatment with bST increased the steady state concentration of oxytocin receptor (OTR) mRNA; bSTtreated cyclic (bST-C) cows had greater OTR mRNA than bST-treated pregnant (bST-P) cows. Estradiol receptor α (ERα) mRNA was reduced in bST-P cows compared with control P and C (no bST) cows. Western blotting revealed that pregnancy decreased the abundance of ERα protein, and bST stimulated an increase in ERα protein in C and P cows. Treatment with bST increased steady state concentrations of progesterone receptor (PR) mRNA. No differences were detected in steady state mRNA concentrations of prostaglandin H synthase-2 (PGHS-2), prostaglandin E synthase, and prostaglandin F synthase due to pregnancy or bST treatment. However, PGHS-2 protein was increased in response to pregnancy and bST treatment. Immunostaining indicated that P decreased ERα protein in luminal epithelium and increased PR protein in epithelial cells of the uterine glands. The PR protein response in the glands was less in bST-P cows than in P cows. In the stromal layer of the endometrium, bST decreased PR protein abundance in C and P cows. The PGHS-2 protein was localized exclusively in the luminal epithelium cells of endometrium and was increased in P cows. In conclusion, distinctly different mRNA and protein responses were detected between C and P cows related to prostaglandin biosynthesis, and bST-induced changes may potentially impact mechanisms associated with maintenance of pregnancy in nonlactating cows.
| 2004 | |
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BOVINOS VACAS LECHERAS GESTACION ENDOMETRIO SOMATOTROPINA BOVINA |
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| Español | |
| Universidad de la República | |
| COLIBRI | |
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https://hdl.handle.net/20.500.12008/51548
https://doi.org/10.3168/jds.S0022-0302(04)73463-3 |
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| Acceso abierto | |
| Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| _version_ | 1877555175310229504 |
|---|---|
| author | Guzeloglu, A. |
| author2 | Bilby, T.R. Meikle, Ana Kamimura, S. Kowalski, A. Michel, F. MacLaren, L.A. Thatcher, W.W. |
| author2_role | author author author author author author author |
| author_facet | Guzeloglu, A. Bilby, T.R. Meikle, Ana Kamimura, S. Kowalski, A. Michel, F. MacLaren, L.A. Thatcher, W.W. |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Guzeloglu A., University of Florida (Gainesville, Florida). Department of Animal Sciences Bilby T.R., University of Florida (Gainesville, Florida). Department of Animal Sciences Meikle Ana, University of Uruguay (Uruguay). Faculty of Veterinary Medicine. Department of Biochemistry Kamimura S., Kagoshima University (Kagoshima, Japan). Faculty of Agriculture. Department of Veterinary Medicine Kowalski A., Universidad Centroccidental Lisandro Alvarado (Barquisimeto, Lara, Venezuela). Dept. Animal Production. College of Agriculture Michel F., University of Florida (Gainesville, Florida). Department of Animal Sciences MacLaren L.A., Nova Scotia Agricultural College (Truro, Canada). Department of Plant and Animal Sciences Thatcher W.W., University of Florida (Gainesville, Florida). Department of Animal Sciences |
| dc.creator.none.fl_str_mv | Guzeloglu, A. Bilby, T.R. Meikle, Ana Kamimura, S. Kowalski, A. Michel, F. MacLaren, L.A. Thatcher, W.W. |
| dc.date.accessioned.none.fl_str_mv | 2025-09-10T14:17:38Z |
| dc.date.available.none.fl_str_mv | 2025-09-10T14:17:38Z |
| dc.date.issued.none.fl_str_mv | 2004 |
| dc.description.abstract.none.fl_txt_mv | The objective was to evaluate the effects of pregnancy and bovine somatotropin (bST) on endometrial gene and protein expression related to maintenance of pregnancy in nonlactating dairy cows at d 17. In endometrial tissues, treatment with bST increased the steady state concentration of oxytocin receptor (OTR) mRNA; bSTtreated cyclic (bST-C) cows had greater OTR mRNA than bST-treated pregnant (bST-P) cows. Estradiol receptor α (ERα) mRNA was reduced in bST-P cows compared with control P and C (no bST) cows. Western blotting revealed that pregnancy decreased the abundance of ERα protein, and bST stimulated an increase in ERα protein in C and P cows. Treatment with bST increased steady state concentrations of progesterone receptor (PR) mRNA. No differences were detected in steady state mRNA concentrations of prostaglandin H synthase-2 (PGHS-2), prostaglandin E synthase, and prostaglandin F synthase due to pregnancy or bST treatment. However, PGHS-2 protein was increased in response to pregnancy and bST treatment. Immunostaining indicated that P decreased ERα protein in luminal epithelium and increased PR protein in epithelial cells of the uterine glands. The PR protein response in the glands was less in bST-P cows than in P cows. In the stromal layer of the endometrium, bST decreased PR protein abundance in C and P cows. The PGHS-2 protein was localized exclusively in the luminal epithelium cells of endometrium and was increased in P cows. In conclusion, distinctly different mRNA and protein responses were detected between C and P cows related to prostaglandin biosynthesis, and bST-induced changes may potentially impact mechanisms associated with maintenance of pregnancy in nonlactating cows. |
| dc.format.extent.es.fl_str_mv | 12 p |
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| dc.identifier.citation.es.fl_str_mv | Guzeloglu, A, Bilby, T, Meikle, A, Kamimura, S, Kowalski, A, Michel, F, MacLaren, L y Thatcher, W. Pregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of Pregnancy. Journal of Dairy Science. [en línea] 2004, 87(10), 3268–3279 |
| dc.identifier.doi.none.fl_str_mv | https://doi.org/10.3168/jds.S0022-0302(04)73463-3 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/51548 |
| dc.language.iso.none.fl_str_mv | es spa |
| dc.relation.none.fl_str_mv | Journal of Dairy Science, 2004, 87(10), 3268–3279 |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.other.es.fl_str_mv | BOVINOS VACAS LECHERAS GESTACION ENDOMETRIO SOMATOTROPINA BOVINA |
| dc.title.none.fl_str_mv | Pregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of Pregnancy |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | The objective was to evaluate the effects of pregnancy and bovine somatotropin (bST) on endometrial gene and protein expression related to maintenance of pregnancy in nonlactating dairy cows at d 17. In endometrial tissues, treatment with bST increased the steady state concentration of oxytocin receptor (OTR) mRNA; bSTtreated cyclic (bST-C) cows had greater OTR mRNA than bST-treated pregnant (bST-P) cows. Estradiol receptor α (ERα) mRNA was reduced in bST-P cows compared with control P and C (no bST) cows. Western blotting revealed that pregnancy decreased the abundance of ERα protein, and bST stimulated an increase in ERα protein in C and P cows. Treatment with bST increased steady state concentrations of progesterone receptor (PR) mRNA. No differences were detected in steady state mRNA concentrations of prostaglandin H synthase-2 (PGHS-2), prostaglandin E synthase, and prostaglandin F synthase due to pregnancy or bST treatment. However, PGHS-2 protein was increased in response to pregnancy and bST treatment. Immunostaining indicated that P decreased ERα protein in luminal epithelium and increased PR protein in epithelial cells of the uterine glands. The PR protein response in the glands was less in bST-P cows than in P cows. In the stromal layer of the endometrium, bST decreased PR protein abundance in C and P cows. The PGHS-2 protein was localized exclusively in the luminal epithelium cells of endometrium and was increased in P cows. In conclusion, distinctly different mRNA and protein responses were detected between C and P cows related to prostaglandin biosynthesis, and bST-induced changes may potentially impact mechanisms associated with maintenance of pregnancy in nonlactating cows. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_a2daef1829b3d2f429bd43846f22367c |
| identifier_str_mv | Guzeloglu, A, Bilby, T, Meikle, A, Kamimura, S, Kowalski, A, Michel, F, MacLaren, L y Thatcher, W. Pregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of Pregnancy. Journal of Dairy Science. [en línea] 2004, 87(10), 3268–3279 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | spa |
| language_invalid_str_mv | es |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/51548 |
| publishDate | 2004 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | karina.camps@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Guzeloglu A., University of Florida (Gainesville, Florida). Department of Animal SciencesBilby T.R., University of Florida (Gainesville, Florida). Department of Animal SciencesMeikle Ana, University of Uruguay (Uruguay). Faculty of Veterinary Medicine. Department of BiochemistryKamimura S., Kagoshima University (Kagoshima, Japan). Faculty of Agriculture. Department of Veterinary MedicineKowalski A., Universidad Centroccidental Lisandro Alvarado (Barquisimeto, Lara, Venezuela). Dept. Animal Production. College of AgricultureMichel F., University of Florida (Gainesville, Florida). Department of Animal SciencesMacLaren L.A., Nova Scotia Agricultural College (Truro, Canada). Department of Plant and Animal SciencesThatcher W.W., University of Florida (Gainesville, Florida). Department of Animal Sciences2025-09-10T14:17:38Z2025-09-10T14:17:38Z2004Guzeloglu, A, Bilby, T, Meikle, A, Kamimura, S, Kowalski, A, Michel, F, MacLaren, L y Thatcher, W. Pregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of Pregnancy. Journal of Dairy Science. [en línea] 2004, 87(10), 3268–3279https://hdl.handle.net/20.500.12008/51548https://doi.org/10.3168/jds.S0022-0302(04)73463-3The objective was to evaluate the effects of pregnancy and bovine somatotropin (bST) on endometrial gene and protein expression related to maintenance of pregnancy in nonlactating dairy cows at d 17. In endometrial tissues, treatment with bST increased the steady state concentration of oxytocin receptor (OTR) mRNA; bSTtreated cyclic (bST-C) cows had greater OTR mRNA than bST-treated pregnant (bST-P) cows. Estradiol receptor α (ERα) mRNA was reduced in bST-P cows compared with control P and C (no bST) cows. Western blotting revealed that pregnancy decreased the abundance of ERα protein, and bST stimulated an increase in ERα protein in C and P cows. Treatment with bST increased steady state concentrations of progesterone receptor (PR) mRNA. No differences were detected in steady state mRNA concentrations of prostaglandin H synthase-2 (PGHS-2), prostaglandin E synthase, and prostaglandin F synthase due to pregnancy or bST treatment. However, PGHS-2 protein was increased in response to pregnancy and bST treatment. Immunostaining indicated that P decreased ERα protein in luminal epithelium and increased PR protein in epithelial cells of the uterine glands. The PR protein response in the glands was less in bST-P cows than in P cows. In the stromal layer of the endometrium, bST decreased PR protein abundance in C and P cows. The PGHS-2 protein was localized exclusively in the luminal epithelium cells of endometrium and was increased in P cows. In conclusion, distinctly different mRNA and protein responses were detected between C and P cows related to prostaglandin biosynthesis, and bST-induced changes may potentially impact mechanisms associated with maintenance of pregnancy in nonlactating cows.Submitted by García Alastra Leticia (lgarcia@fvet.edu.uy) on 2025-09-10T14:17:38Z No. of bitstreams: 2 license_rdf: 26539 bytes, checksum: 3b50ae24bd8bd076d49a70878a8a2d2c (MD5) M30.pdf: 849680 bytes, checksum: d80531140873ded90381301bb8926424 (MD5)Made available in DSpace by García Alastra Leticia (lgarcia@fvet.edu.uy) on 2025-09-10T14:17:38Z (GMT). No. of bitstreams: 2 license_rdf: 26539 bytes, checksum: 3b50ae24bd8bd076d49a70878a8a2d2c (MD5) M30.pdf: 849680 bytes, checksum: d80531140873ded90381301bb8926424 (MD5) Previous issue date: 200412 papplication/pdfesspaJournal of Dairy Science, 2004, 87(10), 3268–3279Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)BOVINOSVACAS LECHERASGESTACIONENDOMETRIOSOMATOTROPINA BOVINAPregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of PregnancyArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaGuzeloglu, A.Bilby, T.R.Meikle, AnaKamimura, S.Kowalski, A.Michel, F.MacLaren, L.A.Thatcher, W.W.LICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/51548/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-850http://localhost:8080/xmlui/bitstream/20.500.12008/51548/2/license_urla006180e3f5b2ad0b88185d14284c0e0MD52license_textlicense_texttext/html; charset=utf-829438http://localhost:8080/xmlui/bitstream/20.500.12008/51548/3/license_text0feedbc93c9013cb52b8473c08f41376MD53license_rdflicense_rdfapplication/rdf+xml; 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- Universidad de la Repúblicafalse |
| spellingShingle | Pregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of Pregnancy Guzeloglu, A. BOVINOS VACAS LECHERAS GESTACION ENDOMETRIO SOMATOTROPINA BOVINA |
| status_str | publishedVersion |
| title | Pregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of Pregnancy |
| title_full | Pregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of Pregnancy |
| title_fullStr | Pregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of Pregnancy |
| title_full_unstemmed | Pregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of Pregnancy |
| title_short | Pregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of Pregnancy |
| title_sort | Pregnancy and Bovine Somatotropin in Nonlactating Dairy Cows: II. Endometrial Gene Expression Related to Maintenance of Pregnancy |
| topic | BOVINOS VACAS LECHERAS GESTACION ENDOMETRIO SOMATOTROPINA BOVINA |
| url | https://hdl.handle.net/20.500.12008/51548 https://doi.org/10.3168/jds.S0022-0302(04)73463-3 |
