Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity?
Resumen:
Cell extrusion is an active mechanism to eliminate non-viable or supernumerary cells in healthy epithelia. It also plays a role in carcinogenesis, both in tumor growth (apical extrusion) and metastasis (basal extrusion). Embryonic tissues like the neuroepithelium, on the other hand, present rates of proliferation comparable to that of carcinomas, without the occurrence of cell extrusion. However, the downregulation or phosphorylation of actin modulating proteins like MARCKS, causes extensive neuroepithelial apical cell extrusion. As changes in MARCKS proteins phosphorylation and expression have also been correlated to carcinogenesis, we propose here an integrated model for their functions in epithelial integrity.
| 2022 | |
| CSIC: 125-347 | |
|
Epithelial-mesenchymal plasticity Carcinoma Neurulation Neuroepithelium Phosphorylation |
|
| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/40608 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1807522799844065280 |
|---|---|
| author | Veloz, Lucía |
| author2 | Bosch Roascio, Santiago Alejandro Aparicio Díaz, Hector Gonzalo Zolessi, Flavio R. |
| author2_role | author author author |
| author_facet | Veloz, Lucía Bosch Roascio, Santiago Alejandro Aparicio Díaz, Hector Gonzalo Zolessi, Flavio R. |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Veloz Lucía, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Bosch Roascio Santiago Alejandro, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Aparicio Díaz Hector Gonzalo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Zolessi Flavio R., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. |
| dc.creator.none.fl_str_mv | Veloz, Lucía Bosch Roascio, Santiago Alejandro Aparicio Díaz, Hector Gonzalo Zolessi, Flavio R. |
| dc.date.accessioned.none.fl_str_mv | 2023-10-10T11:53:08Z |
| dc.date.available.none.fl_str_mv | 2023-10-10T11:53:08Z |
| dc.date.issued.none.fl_str_mv | 2022 |
| dc.description.abstract.none.fl_txt_mv | Cell extrusion is an active mechanism to eliminate non-viable or supernumerary cells in healthy epithelia. It also plays a role in carcinogenesis, both in tumor growth (apical extrusion) and metastasis (basal extrusion). Embryonic tissues like the neuroepithelium, on the other hand, present rates of proliferation comparable to that of carcinomas, without the occurrence of cell extrusion. However, the downregulation or phosphorylation of actin modulating proteins like MARCKS, causes extensive neuroepithelial apical cell extrusion. As changes in MARCKS proteins phosphorylation and expression have also been correlated to carcinogenesis, we propose here an integrated model for their functions in epithelial integrity. |
| dc.description.sponsorship.none.fl_txt_mv | CSIC: 125-347 |
| dc.format.extent.es.fl_str_mv | 6 h. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Veloz, L, Bosch Roascio, S, Aparicio Díaz, H [y otros autores]. "Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity?". Biocell. [en línea] 2022, 46(3): 639-644. 6 h. DOI: 10.32604/biocell.2022.018798 |
| dc.identifier.doi.none.fl_str_mv | 10.32604/biocell.2022.018798 |
| dc.identifier.issn.none.fl_str_mv | 1667-5746 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/40608 |
| dc.language.iso.none.fl_str_mv | en_US eng |
| dc.publisher.es.fl_str_mv | Tech Science Press |
| dc.relation.ispartof.es.fl_str_mv | Biocell, 2022, 46(3): 639-644. |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Epithelial-mesenchymal plasticity Carcinoma Neurulation Neuroepithelium Phosphorylation |
| dc.title.none.fl_str_mv | Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity? |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Cell extrusion is an active mechanism to eliminate non-viable or supernumerary cells in healthy epithelia. It also plays a role in carcinogenesis, both in tumor growth (apical extrusion) and metastasis (basal extrusion). Embryonic tissues like the neuroepithelium, on the other hand, present rates of proliferation comparable to that of carcinomas, without the occurrence of cell extrusion. However, the downregulation or phosphorylation of actin modulating proteins like MARCKS, causes extensive neuroepithelial apical cell extrusion. As changes in MARCKS proteins phosphorylation and expression have also been correlated to carcinogenesis, we propose here an integrated model for their functions in epithelial integrity. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_a15028bd03a189c42bc5ca367dd663aa |
| identifier_str_mv | Veloz, L, Bosch Roascio, S, Aparicio Díaz, H [y otros autores]. "Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity?". Biocell. [en línea] 2022, 46(3): 639-644. 6 h. DOI: 10.32604/biocell.2022.018798 1667-5746 10.32604/biocell.2022.018798 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en_US |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/40608 |
| publishDate | 2022 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Veloz Lucía, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Bosch Roascio Santiago Alejandro, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Aparicio Díaz Hector Gonzalo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Zolessi Flavio R., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.2023-10-10T11:53:08Z2023-10-10T11:53:08Z2022Veloz, L, Bosch Roascio, S, Aparicio Díaz, H [y otros autores]. "Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity?". Biocell. [en línea] 2022, 46(3): 639-644. 6 h. DOI: 10.32604/biocell.2022.0187981667-5746https://hdl.handle.net/20.500.12008/4060810.32604/biocell.2022.018798Cell extrusion is an active mechanism to eliminate non-viable or supernumerary cells in healthy epithelia. It also plays a role in carcinogenesis, both in tumor growth (apical extrusion) and metastasis (basal extrusion). Embryonic tissues like the neuroepithelium, on the other hand, present rates of proliferation comparable to that of carcinomas, without the occurrence of cell extrusion. However, the downregulation or phosphorylation of actin modulating proteins like MARCKS, causes extensive neuroepithelial apical cell extrusion. As changes in MARCKS proteins phosphorylation and expression have also been correlated to carcinogenesis, we propose here an integrated model for their functions in epithelial integrity.Submitted by Farías Verónica (vfarias@fcien.edu.uy) on 2023-10-09T17:45:17Z No. of bitstreams: 2 license_rdf: 24251 bytes, checksum: 71ed42ef0a0b648670f707320be37b90 (MD5) TSP_BIOCELL_18798.pdf: 1455719 bytes, checksum: e588c0cfe404de36a366faf776c67e5b (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2023-10-10T11:46:17Z (GMT) No. of bitstreams: 2 license_rdf: 24251 bytes, checksum: 71ed42ef0a0b648670f707320be37b90 (MD5) TSP_BIOCELL_18798.pdf: 1455719 bytes, checksum: e588c0cfe404de36a366faf776c67e5b (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2023-10-10T11:53:08Z (GMT). No. of bitstreams: 2 license_rdf: 24251 bytes, checksum: 71ed42ef0a0b648670f707320be37b90 (MD5) TSP_BIOCELL_18798.pdf: 1455719 bytes, checksum: e588c0cfe404de36a366faf776c67e5b (MD5) Previous issue date: 2022CSIC: 125-3476 h.application/pdfen_USengTech Science PressBiocell, 2022, 46(3): 639-644.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Epithelial-mesenchymal plasticityCarcinomaNeurulationNeuroepitheliumPhosphorylationCell extrusion in development and cancer, what MARCKS the difference for epithelial integrity?Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaVeloz, LucíaBosch Roascio, Santiago AlejandroAparicio Díaz, Hector GonzaloZolessi, Flavio R.LICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/40608/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-844http://localhost:8080/xmlui/bitstream/20.500.12008/40608/2/license_urla0ebbeafb9d2ec7cbb19d7137ebc392cMD52license_textlicense_texttext/html; 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- Universidad de la Repúblicafalse |
| spellingShingle | Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity? Veloz, Lucía Epithelial-mesenchymal plasticity Carcinoma Neurulation Neuroepithelium Phosphorylation |
| status_str | publishedVersion |
| title | Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity? |
| title_full | Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity? |
| title_fullStr | Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity? |
| title_full_unstemmed | Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity? |
| title_short | Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity? |
| title_sort | Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity? |
| topic | Epithelial-mesenchymal plasticity Carcinoma Neurulation Neuroepithelium Phosphorylation |
| url | https://hdl.handle.net/20.500.12008/40608 |
