Machine Learning methods for genome enabled prediction of complex traits : Benchmarking and robustness to marker elimination
Resumen:
A plethora of machine learning and statistical methods have been applied in the context of genome enabled prediction. Here we address the prediction of complex traits from SNP marker data in agriculture. The datasets used present different levels of trait complexity. These are: Yeast yield, Holstein cattle milk yield, German bulls Sire Conception Rate, and Wheat yield. Population structure, number of samples and SNPs also vary among datasets. We benchmark several popular models including bayesian and penalized linear regressions, kernel methods, and decision tree ensembles. Through exhaustive hyperparameter tuning we outperform state-of-the-art results in all datasets.Furthermore, we compare two genome codifications: One hot encoding and Additive encoding, the latter being the standard codification used in quantitative genetics. We show that, in these datasets, additive encoding outperforms categorical encodings despite the fact that the variables are categorical in nature. This difference in performance may be caused by the predominance of additive effects, the dimensionality increase and the loss of the one-to -one correspondence between variables and biological markers. Regarding robustness to random marker elimination, we found that on all datasets most models present a negligible loss in predictive power even when trained on a small, random sample of markers. We argue that sample size limits the amount of SNPs which are informative with respect to the downstream prediction task.
2021 | |
Este trabajo fue parcialmente financiado por el proyecto ANII FSDA 1-2018-1-154364. | |
Genomic prediction Machine learning Dimensionality reduction |
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Inglés | |
Universidad de la República | |
COLIBRI | |
https://meetings.cshl.edu/meetings.aspx?meet=PROBGEN&year=21
https://hdl.handle.net/20.500.12008/36814 |
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Acceso abierto | |
Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
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---|---|
author | Elenter, Juan |
author2 | Etchebarne, Guillermo Hounie, Ignacio Fariello, María Inés Lecumberry, Federico |
author2_role | author author author author |
author_facet | Elenter, Juan Etchebarne, Guillermo Hounie, Ignacio Fariello, María Inés Lecumberry, Federico |
author_role | author |
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collection | COLIBRI |
dc.contributor.filiacion.none.fl_str_mv | Elenter Juan, Universidad de la República (Uruguay). Facultad de Ingeniería. Etchebarne Guillermo, Universidad de la República (Uruguay). Facultad de Ingeniería. Hounie Ignacio, Universidad de la República (Uruguay). Facultad de Ingeniería. Fariello María Inés, Universidad de la República (Uruguay). Facultad de Ingeniería. Lecumberry Federico, Universidad de la República (Uruguay). Facultad de Ingeniería. |
dc.creator.none.fl_str_mv | Elenter, Juan Etchebarne, Guillermo Hounie, Ignacio Fariello, María Inés Lecumberry, Federico |
dc.date.accessioned.none.fl_str_mv | 2023-04-26T11:47:08Z |
dc.date.available.none.fl_str_mv | 2023-04-26T11:47:08Z |
dc.date.issued.none.fl_str_mv | 2021 |
dc.description.abstract.none.fl_txt_mv | A plethora of machine learning and statistical methods have been applied in the context of genome enabled prediction. Here we address the prediction of complex traits from SNP marker data in agriculture. The datasets used present different levels of trait complexity. These are: Yeast yield, Holstein cattle milk yield, German bulls Sire Conception Rate, and Wheat yield. Population structure, number of samples and SNPs also vary among datasets. We benchmark several popular models including bayesian and penalized linear regressions, kernel methods, and decision tree ensembles. Through exhaustive hyperparameter tuning we outperform state-of-the-art results in all datasets.Furthermore, we compare two genome codifications: One hot encoding and Additive encoding, the latter being the standard codification used in quantitative genetics. We show that, in these datasets, additive encoding outperforms categorical encodings despite the fact that the variables are categorical in nature. This difference in performance may be caused by the predominance of additive effects, the dimensionality increase and the loss of the one-to -one correspondence between variables and biological markers. Regarding robustness to random marker elimination, we found that on all datasets most models present a negligible loss in predictive power even when trained on a small, random sample of markers. We argue that sample size limits the amount of SNPs which are informative with respect to the downstream prediction task. |
dc.description.es.fl_txt_mv | Los experimentos presentados en este trabajo se realizaron utilizando ClusterUy (sitio: https://cluster.uy). |
dc.description.sponsorship.none.fl_txt_mv | Este trabajo fue parcialmente financiado por el proyecto ANII FSDA 1-2018-1-154364. |
dc.format.extent.es.fl_str_mv | 1 p. |
dc.format.mimetype.es.fl_str_mv | application/pdf |
dc.identifier.citation.es.fl_str_mv | Elenter, J., Etchebarne, G., Hounie, I. y otros. Machine Learning methods for genome enabled prediction of complex traits [en línea]. Póster, 2021. |
dc.identifier.uri.none.fl_str_mv | https://meetings.cshl.edu/meetings.aspx?meet=PROBGEN&year=21 https://hdl.handle.net/20.500.12008/36814 |
dc.language.iso.none.fl_str_mv | en eng |
dc.publisher.es.fl_str_mv | Cold Spring Harbor Laboratory (CSHL) |
dc.relation.ispartof.es.fl_str_mv | Probabilistic Modeling in Genomics : Virtual Meeting, 14-16 apr. 2021, Cold Spring Harbor, NY, USA. |
dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
dc.subject.es.fl_str_mv | Genomic prediction Machine learning Dimensionality reduction |
dc.title.none.fl_str_mv | Machine Learning methods for genome enabled prediction of complex traits : Benchmarking and robustness to marker elimination |
dc.type.es.fl_str_mv | Póster |
dc.type.none.fl_str_mv | info:eu-repo/semantics/conferenceObject |
dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
description | Los experimentos presentados en este trabajo se realizaron utilizando ClusterUy (sitio: https://cluster.uy). |
eu_rights_str_mv | openAccess |
format | conferenceObject |
id | COLIBRI_a0f53e74c4a7cc593aaccffca32fc45d |
identifier_str_mv | Elenter, J., Etchebarne, G., Hounie, I. y otros. Machine Learning methods for genome enabled prediction of complex traits [en línea]. Póster, 2021. |
instacron_str | Universidad de la República |
institution | Universidad de la República |
instname_str | Universidad de la República |
language | eng |
language_invalid_str_mv | en |
network_acronym_str | COLIBRI |
network_name_str | COLIBRI |
oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/36814 |
publishDate | 2021 |
reponame_str | COLIBRI |
repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
repository.name.fl_str_mv | COLIBRI - Universidad de la República |
repository_id_str | 4771 |
rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
spelling | Elenter Juan, Universidad de la República (Uruguay). Facultad de Ingeniería.Etchebarne Guillermo, Universidad de la República (Uruguay). Facultad de Ingeniería.Hounie Ignacio, Universidad de la República (Uruguay). Facultad de Ingeniería.Fariello María Inés, Universidad de la República (Uruguay). Facultad de Ingeniería.Lecumberry Federico, Universidad de la República (Uruguay). Facultad de Ingeniería.2023-04-26T11:47:08Z2023-04-26T11:47:08Z2021Elenter, J., Etchebarne, G., Hounie, I. y otros. Machine Learning methods for genome enabled prediction of complex traits [en línea]. Póster, 2021.https://meetings.cshl.edu/meetings.aspx?meet=PROBGEN&year=21https://hdl.handle.net/20.500.12008/36814Los experimentos presentados en este trabajo se realizaron utilizando ClusterUy (sitio: https://cluster.uy).A plethora of machine learning and statistical methods have been applied in the context of genome enabled prediction. Here we address the prediction of complex traits from SNP marker data in agriculture. The datasets used present different levels of trait complexity. These are: Yeast yield, Holstein cattle milk yield, German bulls Sire Conception Rate, and Wheat yield. Population structure, number of samples and SNPs also vary among datasets. We benchmark several popular models including bayesian and penalized linear regressions, kernel methods, and decision tree ensembles. Through exhaustive hyperparameter tuning we outperform state-of-the-art results in all datasets.Furthermore, we compare two genome codifications: One hot encoding and Additive encoding, the latter being the standard codification used in quantitative genetics. We show that, in these datasets, additive encoding outperforms categorical encodings despite the fact that the variables are categorical in nature. This difference in performance may be caused by the predominance of additive effects, the dimensionality increase and the loss of the one-to -one correspondence between variables and biological markers. Regarding robustness to random marker elimination, we found that on all datasets most models present a negligible loss in predictive power even when trained on a small, random sample of markers. We argue that sample size limits the amount of SNPs which are informative with respect to the downstream prediction task.Submitted by Ribeiro Jorge (jribeiro@fing.edu.uy) on 2023-04-24T01:53:37Z No. of bitstreams: 2 license_rdf: 23149 bytes, checksum: 1996b8461bc290aef6a27d78c67b6b52 (MD5) EEHFL21a.pdf: 960648 bytes, checksum: 5adca3940792d19f941711d6ce679a9e (MD5)Approved for entry into archive by Machado Jimena (jmachado@fing.edu.uy) on 2023-04-24T18:14:36Z (GMT) No. of bitstreams: 2 license_rdf: 23149 bytes, checksum: 1996b8461bc290aef6a27d78c67b6b52 (MD5) EEHFL21a.pdf: 960648 bytes, checksum: 5adca3940792d19f941711d6ce679a9e (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2023-04-26T11:47:08Z (GMT). No. of bitstreams: 2 license_rdf: 23149 bytes, checksum: 1996b8461bc290aef6a27d78c67b6b52 (MD5) EEHFL21a.pdf: 960648 bytes, checksum: 5adca3940792d19f941711d6ce679a9e (MD5) Previous issue date: 2021Este trabajo fue parcialmente financiado por el proyecto ANII FSDA 1-2018-1-154364.1 p.application/pdfenengCold Spring Harbor Laboratory (CSHL)Probabilistic Modeling in Genomics : Virtual Meeting, 14-16 apr. 2021, Cold Spring Harbor, NY, USA.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)Genomic predictionMachine learningDimensionality reductionMachine Learning methods for genome enabled prediction of complex traits : Benchmarking and robustness to marker eliminationPósterinfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaElenter, JuanEtchebarne, GuillermoHounie, IgnacioFariello, María InésLecumberry, FedericoLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/36814/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-850http://localhost:8080/xmlui/bitstream/20.500.12008/36814/2/license_urla006180e3f5b2ad0b88185d14284c0e0MD52license_textlicense_texttext/html; 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- Universidad de la Repúblicafalse |
spellingShingle | Machine Learning methods for genome enabled prediction of complex traits : Benchmarking and robustness to marker elimination Elenter, Juan Genomic prediction Machine learning Dimensionality reduction |
status_str | publishedVersion |
title | Machine Learning methods for genome enabled prediction of complex traits : Benchmarking and robustness to marker elimination |
title_full | Machine Learning methods for genome enabled prediction of complex traits : Benchmarking and robustness to marker elimination |
title_fullStr | Machine Learning methods for genome enabled prediction of complex traits : Benchmarking and robustness to marker elimination |
title_full_unstemmed | Machine Learning methods for genome enabled prediction of complex traits : Benchmarking and robustness to marker elimination |
title_short | Machine Learning methods for genome enabled prediction of complex traits : Benchmarking and robustness to marker elimination |
title_sort | Machine Learning methods for genome enabled prediction of complex traits : Benchmarking and robustness to marker elimination |
topic | Genomic prediction Machine learning Dimensionality reduction |
url | https://meetings.cshl.edu/meetings.aspx?meet=PROBGEN&year=21 https://hdl.handle.net/20.500.12008/36814 |