Comparative genomics of the major parasitic worms
Resumen:
Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report a broad comparative study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritized new potential drug targets and compounds for testing. This comparative genomics resource provides a much-needed boost for the research community to understand and combat parasitic worms.
| 2019 | |
| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/27620 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1807522785469136896 |
|---|---|
| author | Coghlan, A. |
| author2 | Cotton, J.A. Holroyd, N. Reid, A.J. Ribeiro, D.M. Stanley, Eleanor Beasley, H. Bennett, H.M. Doyle, S.R. Gordon, D. Harsha, B. Huckvale, T. Lomax, J. Rinaldi, Gabriel Shafie, M. Tracey, A. Berriman, Matthew Tyagi, R. Rosa, B.A. Tsai, I.J. Laetsch, D.R. Beech, R.N. Day, T.A. Hallsworth-Pepin, K. Huei-Mien, K. Tzu-Hao, K. Lee, T.J. Martin, J. Maizels, R.M. Mutowo, P. Ozersky, P. Parkinson, J. Rawlings, N.D. Swapna, L.S. Taylor, D.W. Wheeler, N.J. Zamanian, M. Xu, Z. Allan, F. Allen, Judith E. Asano, K. Babayan, S.A. Bah, G. Bisset, S.A. Castillo Presa, Estela Beatriz Cook, J. Cooper, P.J. Cruz-Bustos, T. Cuéllar, C. Devaney, E. Eberhard, M.L. Emery, A. Eom, K.S. Gilleard, J.S. Harcus, Y. Hawdon, J.M. Hill, D.E. Hodgkinson, J. Horák, P. Howe, K.L. Kalbe, M. Kaur, G. Kikuchi, T. Koutsovoulos, G. Kumar, S. Leach, A.R. Makepeace, B. Matthews, J.B. Muro, A. O’Boyle, N.M. Olson, P.D. Partono, F. Pfarr, K. Foronda, P. Rollinson, D. Gomez Samblas, M. Sato, H. Schnyder, M. Scholz, T. Tanya, V.N. Toledo, R. Urban, J.F. Lian-Cheng, W. Zarlenga, D. Blaxter, M.L. Mitreva, M. |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Coghlan, A. Cotton, J.A. Holroyd, N. Reid, A.J. Ribeiro, D.M. Stanley, Eleanor Beasley, H. Bennett, H.M. Doyle, S.R. Gordon, D. Harsha, B. Huckvale, T. Lomax, J. Rinaldi, Gabriel Shafie, M. Tracey, A. Berriman, Matthew Tyagi, R. Rosa, B.A. Tsai, I.J. Laetsch, D.R. Beech, R.N. Day, T.A. Hallsworth-Pepin, K. Huei-Mien, K. Tzu-Hao, K. Lee, T.J. Martin, J. Maizels, R.M. Mutowo, P. Ozersky, P. Parkinson, J. Rawlings, N.D. Swapna, L.S. Taylor, D.W. Wheeler, N.J. Zamanian, M. Xu, Z. Allan, F. Allen, Judith E. Asano, K. Babayan, S.A. Bah, G. Bisset, S.A. Castillo Presa, Estela Beatriz Cook, J. Cooper, P.J. Cruz-Bustos, T. Cuéllar, C. Devaney, E. Eberhard, M.L. Emery, A. Eom, K.S. Gilleard, J.S. Harcus, Y. Hawdon, J.M. Hill, D.E. Hodgkinson, J. Horák, P. Howe, K.L. Kalbe, M. Kaur, G. Kikuchi, T. Koutsovoulos, G. Kumar, S. Leach, A.R. Makepeace, B. Matthews, J.B. Muro, A. O’Boyle, N.M. Olson, P.D. Partono, F. Pfarr, K. Foronda, P. Rollinson, D. Gomez Samblas, M. Sato, H. Schnyder, M. Scholz, T. Tanya, V.N. Toledo, R. Urban, J.F. Lian-Cheng, W. Zarlenga, D. Blaxter, M.L. Mitreva, M. |
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| dc.contributor.filiacion.none.fl_str_mv | Coghlan A. Cotton J.A. Holroyd N. Reid A.J. Ribeiro D.M. Stanley E. Beasley H. Bennett H.M. Doyle S.R. Gordon D. Harsha B. Huckvale T. Lomax J. Rinaldi G. Shafie M. Tracey A. Berriman M. Tyagi R. Rosa B.A. Tsai I.J. Laetsch D.R. Beech R.N. Day T.A. Hallsworth-Pepin K. Huei-Mien K. Tzu-Hao K. Lee T.J. Martin J. Maizels R.M. Mutowo P. Ozersky P. Parkinson J. Rawlings N.D. Swapna L.S. Taylor D.W. Wheeler N.J. Zamanian M. Xu Z. Allan F. Allen J.E. Asano K. Babayan S.A. Bah G. Bisset S.A. Castillo Presa Estela Beatriz, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Cook J. Cooper P.J. Cruz-Bustos T. Cuéllar C. Devaney E. Eberhard M.L. Emery A. Eom K.S. Gilleard J.S. Harcus Y. Hawdon J.M. Hill D.E. Hodgkinson J. Horák P. Howe K.L. Kalbe M. Kaur G. Kikuchi T. Koutsovoulos G. Kumar S. Leach A.R. Makepeace B. Matthews J.B. Muro A. O’Boyle N.M. Olson P.D. Partono F. Pfarr K. Foronda P. Rollinson D. Gomez Samblas M. Sato H. Schnyder M. Scholz T. Tanya V.N. Toledo R. Urban J.F. Lian-Cheng W. Zarlenga D. Blaxter M.L. Mitreva M. |
| dc.creator.none.fl_str_mv | Coghlan, A. Cotton, J.A. Holroyd, N. Reid, A.J. Ribeiro, D.M. Stanley, Eleanor Beasley, H. Bennett, H.M. Doyle, S.R. Gordon, D. Harsha, B. Huckvale, T. Lomax, J. Rinaldi, Gabriel Shafie, M. Tracey, A. Berriman, Matthew Tyagi, R. Rosa, B.A. Tsai, I.J. Laetsch, D.R. Beech, R.N. Day, T.A. Hallsworth-Pepin, K. Huei-Mien, K. Tzu-Hao, K. Lee, T.J. Martin, J. Maizels, R.M. Mutowo, P. Ozersky, P. Parkinson, J. Rawlings, N.D. Swapna, L.S. Taylor, D.W. Wheeler, N.J. Zamanian, M. Xu, Z. Allan, F. Allen, Judith E. Asano, K. Babayan, S.A. Bah, G. Bisset, S.A. Castillo Presa, Estela Beatriz Cook, J. Cooper, P.J. Cruz-Bustos, T. Cuéllar, C. Devaney, E. Eberhard, M.L. Emery, A. Eom, K.S. Gilleard, J.S. Harcus, Y. Hawdon, J.M. Hill, D.E. Hodgkinson, J. Horák, P. Howe, K.L. Kalbe, M. Kaur, G. Kikuchi, T. Koutsovoulos, G. Kumar, S. Leach, A.R. Makepeace, B. Matthews, J.B. Muro, A. O’Boyle, N.M. Olson, P.D. Partono, F. Pfarr, K. Foronda, P. Rollinson, D. Gomez Samblas, M. Sato, H. Schnyder, M. Scholz, T. Tanya, V.N. Toledo, R. Urban, J.F. Lian-Cheng, W. Zarlenga, D. Blaxter, M.L. Mitreva, M. |
| dc.date.accessioned.none.fl_str_mv | 2021-05-11T14:25:51Z |
| dc.date.available.none.fl_str_mv | 2021-05-11T14:25:51Z |
| dc.date.issued.none.fl_str_mv | 2019 |
| dc.description.abstract.none.fl_txt_mv | Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report a broad comparative study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritized new potential drug targets and compounds for testing. This comparative genomics resource provides a much-needed boost for the research community to understand and combat parasitic worms. |
| dc.description.es.fl_txt_mv | Los autores forman parte del International Helminth Genomes Consortium |
| dc.format.extent.es.fl_str_mv | 19 h. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Coghlan, A, Cotton, J, Holroyd, N., y otros "Comparative genomics of the major parasitic worms". Nature Genetics. [en línea] 2019, 51: 163-174. 19 h. DOI: 10.1038/s41588-018-0262-1 |
| dc.identifier.doi.none.fl_str_mv | 10.1038/s41588-018-0262-1 |
| dc.identifier.issn.none.fl_str_mv | 1546-1718 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/27620 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Nature Research |
| dc.relation.ispartof.es.fl_str_mv | Nature Genetics, 2019, 51: 163-174 |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.title.none.fl_str_mv | Comparative genomics of the major parasitic worms |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Los autores forman parte del International Helminth Genomes Consortium |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_a0ea4315a461ebf6c30140803e415d76 |
| identifier_str_mv | Coghlan, A, Cotton, J, Holroyd, N., y otros "Comparative genomics of the major parasitic worms". Nature Genetics. [en línea] 2019, 51: 163-174. 19 h. DOI: 10.1038/s41588-018-0262-1 1546-1718 10.1038/s41588-018-0262-1 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/27620 |
| publishDate | 2019 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Coghlan A.Cotton J.A.Holroyd N.Reid A.J.Ribeiro D.M.Stanley E.Beasley H.Bennett H.M.Doyle S.R.Gordon D.Harsha B.Huckvale T.Lomax J.Rinaldi G.Shafie M.Tracey A.Berriman M.Tyagi R.Rosa B.A.Tsai I.J.Laetsch D.R.Beech R.N.Day T.A.Hallsworth-Pepin K.Huei-Mien K.Tzu-Hao K.Lee T.J.Martin J.Maizels R.M.Mutowo P.Ozersky P.Parkinson J.Rawlings N.D.Swapna L.S.Taylor D.W.Wheeler N.J.Zamanian M.Xu Z.Allan F.Allen J.E.Asano K.Babayan S.A.Bah G.Bisset S.A.Castillo Presa Estela Beatriz, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Cook J.Cooper P.J.Cruz-Bustos T.Cuéllar C.Devaney E.Eberhard M.L.Emery A.Eom K.S.Gilleard J.S.Harcus Y.Hawdon J.M.Hill D.E.Hodgkinson J.Horák P.Howe K.L.Kalbe M.Kaur G.Kikuchi T.Koutsovoulos G.Kumar S.Leach A.R.Makepeace B.Matthews J.B.Muro A.O’Boyle N.M.Olson P.D.Partono F.Pfarr K.Foronda P.Rollinson D.Gomez Samblas M.Sato H.Schnyder M.Scholz T.Tanya V.N.Toledo R.Urban J.F.Lian-Cheng W.Zarlenga D.Blaxter M.L.Mitreva M.2021-05-11T14:25:51Z2021-05-11T14:25:51Z2019Coghlan, A, Cotton, J, Holroyd, N., y otros "Comparative genomics of the major parasitic worms". Nature Genetics. [en línea] 2019, 51: 163-174. 19 h. DOI: 10.1038/s41588-018-0262-11546-1718https://hdl.handle.net/20.500.12008/2762010.1038/s41588-018-0262-1Los autores forman parte del International Helminth Genomes ConsortiumParasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report a broad comparative study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritized new potential drug targets and compounds for testing. This comparative genomics resource provides a much-needed boost for the research community to understand and combat parasitic worms.Submitted by Verdun Juan Pablo (jverdun@fcien.edu.uy) on 2021-04-29T21:14:16Z No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10.1038s41588-018-0262-1.pdf: 2585031 bytes, checksum: f5a7de0bc3cd18751530fb12ed966185 (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2021-05-11T14:21:24Z (GMT) No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10.1038s41588-018-0262-1.pdf: 2585031 bytes, checksum: f5a7de0bc3cd18751530fb12ed966185 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2021-05-11T14:25:51Z (GMT). No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10.1038s41588-018-0262-1.pdf: 2585031 bytes, checksum: f5a7de0bc3cd18751530fb12ed966185 (MD5) Previous issue date: 201919 h.application/pdfenengNature ResearchNature Genetics, 2019, 51: 163-174Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Comparative genomics of the major parasitic wormsArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaCoghlan, A.Cotton, J.A.Holroyd, N.Reid, A.J.Ribeiro, D.M.Stanley, EleanorBeasley, H.Bennett, H.M.Doyle, S.R.Gordon, D.Harsha, B.Huckvale, T.Lomax, J.Rinaldi, GabrielShafie, M.Tracey, A.Berriman, MatthewTyagi, R.Rosa, B.A.Tsai, I.J.Laetsch, D.R.Beech, R.N.Day, T.A.Hallsworth-Pepin, K.Huei-Mien, K.Tzu-Hao, K.Lee, T.J.Martin, J.Maizels, R.M.Mutowo, P.Ozersky, P.Parkinson, J.Rawlings, N.D.Swapna, L.S.Taylor, D.W.Wheeler, N.J.Zamanian, M.Xu, Z.Allan, F.Allen, Judith E.Asano, K.Babayan, S.A.Bah, G.Bisset, S.A.Castillo Presa, Estela BeatrizCook, J.Cooper, P.J.Cruz-Bustos, T.Cuéllar, C.Devaney, E.Eberhard, M.L.Emery, A.Eom, K.S.Gilleard, J.S.Harcus, Y.Hawdon, J.M.Hill, 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- Universidad de la Repúblicafalse |
| spellingShingle | Comparative genomics of the major parasitic worms Coghlan, A. |
| status_str | publishedVersion |
| title | Comparative genomics of the major parasitic worms |
| title_full | Comparative genomics of the major parasitic worms |
| title_fullStr | Comparative genomics of the major parasitic worms |
| title_full_unstemmed | Comparative genomics of the major parasitic worms |
| title_short | Comparative genomics of the major parasitic worms |
| title_sort | Comparative genomics of the major parasitic worms |
| url | https://hdl.handle.net/20.500.12008/27620 |
