ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations
Resumen:
The ENAM gene is important in the formation of tooth enamel; an alteration can affect the lengthening of the crystals, and the thickness in enamel. The objective was to determine the presence of the single nucleotide variant (SNV) rs12640848 of the ENAM gene in students exposed to different concentrations of fluoride. Methods: A cross-sectional study was conducted on students exposed to high concentrations of fluoride in the city of Durango which were divided according to the severity of fluorosis and dental caries. Genotype determination was performed by DNA sequencing. The relationship between the severity of dental fluorosis and the allele distribution was determined by the Fisher’s exact and Kruskal–Wallis tests. Results: Seventy-one students were included for the sequencing. In the different allelic variations, for the normal genotype AA/TT, the control group presented 75%, for the AG/TC variation, 70.8% in the TF ≤ 4 group, 65% in TF ≥ 5, and 16.7% in TF = 0; with respect to GG/CC variation, 12.5% in TF ≤ 4, 22% in TF ≥ 5, and 8.3% in TF = 0 group (p = 0.000). Conclusion: The ENAM gene showed an association in the population exposed to different concentrations of fluoride
| 2020 | |
|
Genetic variation Enamelin Dental fluorosis Caries |
|
| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/25950 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1872865336304336896 |
|---|---|
| author | Duran-Merino, Denisse |
| author2 | Molina-Frechero, Nelly Sánchez-Pérez, Leonor Nevárez-Rascón, Martina González González, Rogelio Tremillo-Maldonado, Omar Cassi, Diana Bologna-Molina, Ronell |
| author2_role | author author author author author author author |
| author_facet | Duran-Merino, Denisse Molina-Frechero, Nelly Sánchez-Pérez, Leonor Nevárez-Rascón, Martina González González, Rogelio Tremillo-Maldonado, Omar Cassi, Diana Bologna-Molina, Ronell |
| author_role | author |
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| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 MD5 MD5 MD5 |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Duran-Merino Denisse, . Molina-Frechero Nelly Sánchez-Pérez Leonor Nevárez-Rascón Martina González González Rogelio Tremillo-Maldonado Omar Cassi Diana Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología |
| dc.creator.none.fl_str_mv | Duran-Merino, Denisse Molina-Frechero, Nelly Sánchez-Pérez, Leonor Nevárez-Rascón, Martina González González, Rogelio Tremillo-Maldonado, Omar Cassi, Diana Bologna-Molina, Ronell |
| dc.date.accessioned.none.fl_str_mv | 2020-11-25T13:04:31Z |
| dc.date.available.none.fl_str_mv | 2020-11-25T13:04:31Z |
| dc.date.issued.none.fl_str_mv | 2020 |
| dc.description.abstract.none.fl_txt_mv | The ENAM gene is important in the formation of tooth enamel; an alteration can affect the lengthening of the crystals, and the thickness in enamel. The objective was to determine the presence of the single nucleotide variant (SNV) rs12640848 of the ENAM gene in students exposed to different concentrations of fluoride. Methods: A cross-sectional study was conducted on students exposed to high concentrations of fluoride in the city of Durango which were divided according to the severity of fluorosis and dental caries. Genotype determination was performed by DNA sequencing. The relationship between the severity of dental fluorosis and the allele distribution was determined by the Fisher’s exact and Kruskal–Wallis tests. Results: Seventy-one students were included for the sequencing. In the different allelic variations, for the normal genotype AA/TT, the control group presented 75%, for the AG/TC variation, 70.8% in the TF ≤ 4 group, 65% in TF ≥ 5, and 16.7% in TF = 0; with respect to GG/CC variation, 12.5% in TF ≤ 4, 22% in TF ≥ 5, and 8.3% in TF = 0 group (p = 0.000). Conclusion: The ENAM gene showed an association in the population exposed to different concentrations of fluoride |
| dc.format.mimetype.en.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Duran-Merino, D, Molina-Frechero, N, Sánchez-Pérez, L, y otros. "ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations". International Journal of Environmental Research and Public Health. [en línea] 2020, 17, 1832. doi:10.3390/ijerph17061832 |
| dc.identifier.doi.none.fl_str_mv | doi:10.3390/ijerph17061832 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/25950 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | International Journal of Environmental Research and Public Health, 17, 1832, 2020 |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.en.fl_str_mv | Genetic variation Enamelin Dental fluorosis Caries |
| dc.title.none.fl_str_mv | ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | The ENAM gene is important in the formation of tooth enamel; an alteration can affect the lengthening of the crystals, and the thickness in enamel. The objective was to determine the presence of the single nucleotide variant (SNV) rs12640848 of the ENAM gene in students exposed to different concentrations of fluoride. Methods: A cross-sectional study was conducted on students exposed to high concentrations of fluoride in the city of Durango which were divided according to the severity of fluorosis and dental caries. Genotype determination was performed by DNA sequencing. The relationship between the severity of dental fluorosis and the allele distribution was determined by the Fisher’s exact and Kruskal–Wallis tests. Results: Seventy-one students were included for the sequencing. In the different allelic variations, for the normal genotype AA/TT, the control group presented 75%, for the AG/TC variation, 70.8% in the TF ≤ 4 group, 65% in TF ≥ 5, and 16.7% in TF = 0; with respect to GG/CC variation, 12.5% in TF ≤ 4, 22% in TF ≥ 5, and 8.3% in TF = 0 group (p = 0.000). Conclusion: The ENAM gene showed an association in the population exposed to different concentrations of fluoride |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_8e187ff10ea3d73c695ca1e76e771a96 |
| identifier_str_mv | Duran-Merino, D, Molina-Frechero, N, Sánchez-Pérez, L, y otros. "ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations". International Journal of Environmental Research and Public Health. [en línea] 2020, 17, 1832. doi:10.3390/ijerph17061832 doi:10.3390/ijerph17061832 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/25950 |
| publishDate | 2020 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | karina.camps@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Duran-Merino Denisse, .Molina-Frechero NellySánchez-Pérez LeonorNevárez-Rascón MartinaGonzález González RogelioTremillo-Maldonado OmarCassi DianaBologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología2020-11-25T13:04:31Z2020-11-25T13:04:31Z2020Duran-Merino, D, Molina-Frechero, N, Sánchez-Pérez, L, y otros. "ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations". International Journal of Environmental Research and Public Health. [en línea] 2020, 17, 1832. doi:10.3390/ijerph17061832https://hdl.handle.net/20.500.12008/25950doi:10.3390/ijerph17061832The ENAM gene is important in the formation of tooth enamel; an alteration can affect the lengthening of the crystals, and the thickness in enamel. The objective was to determine the presence of the single nucleotide variant (SNV) rs12640848 of the ENAM gene in students exposed to different concentrations of fluoride. Methods: A cross-sectional study was conducted on students exposed to high concentrations of fluoride in the city of Durango which were divided according to the severity of fluorosis and dental caries. Genotype determination was performed by DNA sequencing. The relationship between the severity of dental fluorosis and the allele distribution was determined by the Fisher’s exact and Kruskal–Wallis tests. Results: Seventy-one students were included for the sequencing. In the different allelic variations, for the normal genotype AA/TT, the control group presented 75%, for the AG/TC variation, 70.8% in the TF ≤ 4 group, 65% in TF ≥ 5, and 16.7% in TF = 0; with respect to GG/CC variation, 12.5% in TF ≤ 4, 22% in TF ≥ 5, and 8.3% in TF = 0 group (p = 0.000). Conclusion: The ENAM gene showed an association in the population exposed to different concentrations of fluorideSubmitted by Luna Fabiana (fabiana.luna@fic.edu.uy) on 2020-11-25T13:02:19Z No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) Enam Gene 2020.pdf: 1186149 bytes, checksum: 70f8bc2ef98f7a3839f7d05a3b91d2c9 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@fic.edu.uy) on 2020-11-25T13:04:31Z (GMT). No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) Enam Gene 2020.pdf: 1186149 bytes, checksum: 70f8bc2ef98f7a3839f7d05a3b91d2c9 (MD5) Previous issue date: 2020application/pdfenengMDPIInternational Journal of Environmental Research and Public Health, 17, 1832, 2020Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Genetic variationEnamelinDental fluorosisCariesENAM Gene Variation in Students Exposed to Different Fluoride ConcentrationsArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaDuran-Merino, DenisseMolina-Frechero, NellySánchez-Pérez, LeonorNevárez-Rascón, MartinaGonzález González, RogelioTremillo-Maldonado, OmarCassi, DianaBologna-Molina, RonellLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/25950/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-844http://localhost:8080/xmlui/bitstream/20.500.12008/25950/2/license_urla0ebbeafb9d2ec7cbb19d7137ebc392cMD52license_textlicense_texttext/html; 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públicahttps://udelar.edu.uy/https://www.colibri.udelar.edu.uy/oai/requestkarina.camps@seciu.edu.uyUruguayopendoar:47712026-03-20T15:00:26COLIBRI - Universidad de la Repúblicafalse |
| spellingShingle | ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations Duran-Merino, Denisse Genetic variation Enamelin Dental fluorosis Caries |
| status_str | publishedVersion |
| title | ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations |
| title_full | ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations |
| title_fullStr | ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations |
| title_full_unstemmed | ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations |
| title_short | ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations |
| title_sort | ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations |
| topic | Genetic variation Enamelin Dental fluorosis Caries |
| url | https://hdl.handle.net/20.500.12008/25950 |
