Lipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progression
Resumen:
Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism. Due to its catalytic activity, LPL is involved in metabolic pathways exploited by various solid and hematologic malignancies to provide an extra energy source to the tumor cell. We and others described a link between the expression of LPL in the tumor cell and a poor clinical outcome of patients suffering Chronic Lymphocytic Leukemia (CLL). This leukemia is characterized by a slow accumulation of mainly quiescent clonal CD5 positive B cells that infiltrates secondary lymphoid organs, bone marrow and peripheral blood. Despite LPL being found to be a reliable molecular marker for CLL prognosis, its functional role and the molecular mechanisms regulating its expression are still matter of debate. Herein we address some of these questions reviewing the current state of the art of LPL research in CLL and providing some insights into where currently unexplored questions may lead to
| 2017 | |
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Lipoprotein lipase Chronic lymphocytic leukemia Cancer Prognostic markers |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/22026 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC –BY 4.0) |
| _version_ | 1807522779726086144 |
|---|---|
| author | Prieto Mena, Daniel |
| author2 | Oppezzo Llorens, Pablo |
| author2_role | author |
| author_facet | Prieto Mena, Daniel Oppezzo Llorens, Pablo |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.es.fl_str_mv | Prieto Mena, Daniel. IIBCE Oppezzo Llorens, Pablo. Instituto Pasteur (Montevideo) |
| dc.creator.none.fl_str_mv | Prieto Mena, Daniel Oppezzo Llorens, Pablo |
| dc.date.accessioned.none.fl_str_mv | 2019-10-02T22:08:31Z |
| dc.date.available.none.fl_str_mv | 2019-10-02T22:08:31Z |
| dc.date.issued.es.fl_str_mv | 2017 |
| dc.date.submitted.es.fl_str_mv | 20190930 |
| dc.description.abstract.none.fl_txt_mv | Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism. Due to its catalytic activity, LPL is involved in metabolic pathways exploited by various solid and hematologic malignancies to provide an extra energy source to the tumor cell. We and others described a link between the expression of LPL in the tumor cell and a poor clinical outcome of patients suffering Chronic Lymphocytic Leukemia (CLL). This leukemia is characterized by a slow accumulation of mainly quiescent clonal CD5 positive B cells that infiltrates secondary lymphoid organs, bone marrow and peripheral blood. Despite LPL being found to be a reliable molecular marker for CLL prognosis, its functional role and the molecular mechanisms regulating its expression are still matter of debate. Herein we address some of these questions reviewing the current state of the art of LPL research in CLL and providing some insights into where currently unexplored questions may lead to |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Prieto, D., Oppezzo, P. Lipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progression. Molecules, 2017, 22 (12): art. 2083. doi: 10.3390molecules22122083 |
| dc.identifier.doi.es.fl_str_mv | 10.3390/molecules22122083 |
| dc.identifier.issn.es.fl_str_mv | 1420-3049 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/22026 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | MDPI |
| dc.relation.ispartof.es.fl_str_mv | Molecules, 2017, 22 (12): art. 2083 |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC –BY 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Lipoprotein lipase Chronic lymphocytic leukemia Cancer Prognostic markers |
| dc.title.none.fl_str_mv | Lipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progression |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism. Due to its catalytic activity, LPL is involved in metabolic pathways exploited by various solid and hematologic malignancies to provide an extra energy source to the tumor cell. We and others described a link between the expression of LPL in the tumor cell and a poor clinical outcome of patients suffering Chronic Lymphocytic Leukemia (CLL). This leukemia is characterized by a slow accumulation of mainly quiescent clonal CD5 positive B cells that infiltrates secondary lymphoid organs, bone marrow and peripheral blood. Despite LPL being found to be a reliable molecular marker for CLL prognosis, its functional role and the molecular mechanisms regulating its expression are still matter of debate. Herein we address some of these questions reviewing the current state of the art of LPL research in CLL and providing some insights into where currently unexplored questions may lead to |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_8b20f1feec94b827ba5c65fa87ab896c |
| identifier_str_mv | Prieto, D., Oppezzo, P. Lipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progression. Molecules, 2017, 22 (12): art. 2083. doi: 10.3390molecules22122083 1420-3049 10.3390/molecules22122083 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/22026 |
| publishDate | 2017 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC –BY 4.0) |
| spelling | Prieto Mena, Daniel. IIBCEOppezzo Llorens, Pablo. Instituto Pasteur (Montevideo)2019-10-02T22:08:31Z2019-10-02T22:08:31Z201720190930Prieto, D., Oppezzo, P. Lipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progression. Molecules, 2017, 22 (12): art. 2083. doi: 10.3390molecules221220831420-3049https://hdl.handle.net/20.500.12008/2202610.3390/molecules22122083Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism. Due to its catalytic activity, LPL is involved in metabolic pathways exploited by various solid and hematologic malignancies to provide an extra energy source to the tumor cell. We and others described a link between the expression of LPL in the tumor cell and a poor clinical outcome of patients suffering Chronic Lymphocytic Leukemia (CLL). This leukemia is characterized by a slow accumulation of mainly quiescent clonal CD5 positive B cells that infiltrates secondary lymphoid organs, bone marrow and peripheral blood. Despite LPL being found to be a reliable molecular marker for CLL prognosis, its functional role and the molecular mechanisms regulating its expression are still matter of debate. Herein we address some of these questions reviewing the current state of the art of LPL research in CLL and providing some insights into where currently unexplored questions may lead toMade available in DSpace on 2019-10-02T22:08:31Z (GMT). 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Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC –BY 4.0)Lipoprotein lipaseChronic lymphocytic leukemiaCancerPrognostic markersLipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progressionArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaPrieto Mena, DanielOppezzo Llorens, 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- Universidad de la Repúblicafalse |
| spellingShingle | Lipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progression Prieto Mena, Daniel Lipoprotein lipase Chronic lymphocytic leukemia Cancer Prognostic markers |
| status_str | publishedVersion |
| title | Lipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progression |
| title_full | Lipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progression |
| title_fullStr | Lipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progression |
| title_full_unstemmed | Lipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progression |
| title_short | Lipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progression |
| title_sort | Lipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progression |
| topic | Lipoprotein lipase Chronic lymphocytic leukemia Cancer Prognostic markers |
| url | https://hdl.handle.net/20.500.12008/22026 |
