mSphere of influence: experimental evolution of RNA viruses

Moratorio, Gonzalo

Resumen:

Gonzalo Moratorio works in the field of experimental evolution of vi-ruses. In this mSphere of Influence article, he reflects on how the papers “Virus at-tenuation by genome-scale changes in codon pair bias” by Coleman et al. (Science320:1784–1787, 2008,https://doi.org/10.1126/science.1155761) and “Codon usage de-termines the mutational robustness, evolutionary capacity, and virulence of an RNAvirus” by Lauring et al. (Cell Host Microbe 12:623–632, 2012,https://doi.org/10.1016/j.chom.2012.10.008) made an impact on his thinking about how to employ syntheticbiology to study experimental evolution of viruses.


Detalles Bibliográficos
2020
Virus attenuation
Synthetic biology
Codon pair bias
Mutational robustness
Inglés
Universidad de la República
COLIBRI
https://hdl.handle.net/20.500.12008/31668
Acceso abierto
Licencia Creative Commons Atribución (CC - By 4.0)
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author Moratorio, Gonzalo
author_facet Moratorio, Gonzalo
author_role author
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collection COLIBRI
dc.contributor.filiacion.none.fl_str_mv Moratorio Gonzalo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares
dc.creator.none.fl_str_mv Moratorio, Gonzalo
dc.date.accessioned.none.fl_str_mv 2022-05-25T17:12:19Z
dc.date.available.none.fl_str_mv 2022-05-25T17:12:19Z
dc.date.issued.none.fl_str_mv 2020
dc.description.abstract.none.fl_txt_mv Gonzalo Moratorio works in the field of experimental evolution of vi-ruses. In this mSphere of Influence article, he reflects on how the papers “Virus at-tenuation by genome-scale changes in codon pair bias” by Coleman et al. (Science320:1784–1787, 2008,https://doi.org/10.1126/science.1155761) and “Codon usage de-termines the mutational robustness, evolutionary capacity, and virulence of an RNAvirus” by Lauring et al. (Cell Host Microbe 12:623–632, 2012,https://doi.org/10.1016/j.chom.2012.10.008) made an impact on his thinking about how to employ syntheticbiology to study experimental evolution of viruses.
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dc.format.mimetype.es.fl_str_mv application/pdf
dc.identifier.citation.es.fl_str_mv Moratorio, G. "mSphere of influence: experimental evolution of RNA viruses". mSphere. [en línea] 2020, 5(2): e00179-20. 2 h. DOI: 10.1128/MSPHERE.00179-20
dc.identifier.doi.none.fl_str_mv 10.1128/MSPHERE.00179-20
dc.identifier.issn.none.fl_str_mv 2379-5042
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12008/31668
dc.language.iso.none.fl_str_mv en
eng
dc.publisher.es.fl_str_mv American Society for Microbiology
dc.relation.ispartof.es.fl_str_mv mSphere, 2020, 5(2): e00179-20
dc.rights.license.none.fl_str_mv Licencia Creative Commons Atribución (CC - By 4.0)
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.source.none.fl_str_mv reponame:COLIBRI
instname:Universidad de la República
instacron:Universidad de la República
dc.subject.es.fl_str_mv Virus attenuation
Synthetic biology
Codon pair bias
Mutational robustness
dc.title.none.fl_str_mv mSphere of influence: experimental evolution of RNA viruses
dc.type.es.fl_str_mv Artículo
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
description Gonzalo Moratorio works in the field of experimental evolution of vi-ruses. In this mSphere of Influence article, he reflects on how the papers “Virus at-tenuation by genome-scale changes in codon pair bias” by Coleman et al. (Science320:1784–1787, 2008,https://doi.org/10.1126/science.1155761) and “Codon usage de-termines the mutational robustness, evolutionary capacity, and virulence of an RNAvirus” by Lauring et al. (Cell Host Microbe 12:623–632, 2012,https://doi.org/10.1016/j.chom.2012.10.008) made an impact on his thinking about how to employ syntheticbiology to study experimental evolution of viruses.
eu_rights_str_mv openAccess
format article
id COLIBRI_7015328559d11c42246c14987e185b46
identifier_str_mv Moratorio, G. "mSphere of influence: experimental evolution of RNA viruses". mSphere. [en línea] 2020, 5(2): e00179-20. 2 h. DOI: 10.1128/MSPHERE.00179-20
2379-5042
10.1128/MSPHERE.00179-20
instacron_str Universidad de la República
institution Universidad de la República
instname_str Universidad de la República
language eng
language_invalid_str_mv en
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oai_identifier_str oai:colibri.udelar.edu.uy:20.500.12008/31668
publishDate 2020
reponame_str COLIBRI
repository.mail.fl_str_mv mabel.seroubian@seciu.edu.uy
repository.name.fl_str_mv COLIBRI - Universidad de la República
repository_id_str 4771
rights_invalid_str_mv Licencia Creative Commons Atribución (CC - By 4.0)
spelling Moratorio Gonzalo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares2022-05-25T17:12:19Z2022-05-25T17:12:19Z2020Moratorio, G. "mSphere of influence: experimental evolution of RNA viruses". mSphere. [en línea] 2020, 5(2): e00179-20. 2 h. DOI: 10.1128/MSPHERE.00179-202379-5042https://hdl.handle.net/20.500.12008/3166810.1128/MSPHERE.00179-20Gonzalo Moratorio works in the field of experimental evolution of vi-ruses. In this mSphere of Influence article, he reflects on how the papers “Virus at-tenuation by genome-scale changes in codon pair bias” by Coleman et al. (Science320:1784–1787, 2008,https://doi.org/10.1126/science.1155761) and “Codon usage de-termines the mutational robustness, evolutionary capacity, and virulence of an RNAvirus” by Lauring et al. (Cell Host Microbe 12:623–632, 2012,https://doi.org/10.1016/j.chom.2012.10.008) made an impact on his thinking about how to employ syntheticbiology to study experimental evolution of viruses.Submitted by Verdun Juan Pablo (jverdun@fcien.edu.uy) on 2022-05-24T22:44:41Z No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10.1128MSPHERE.00179-20.pdf: 170886 bytes, checksum: 8087ce682ab0f848bfac98f44ec61feb (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2022-05-25T17:11:31Z (GMT) No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10.1128MSPHERE.00179-20.pdf: 170886 bytes, checksum: 8087ce682ab0f848bfac98f44ec61feb (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2022-05-25T17:12:19Z (GMT). No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10.1128MSPHERE.00179-20.pdf: 170886 bytes, checksum: 8087ce682ab0f848bfac98f44ec61feb (MD5) Previous issue date: 20202 h.application/pdfenengAmerican Society for MicrobiologymSphere, 2020, 5(2): e00179-20Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Virus attenuationSynthetic biologyCodon pair biasMutational robustnessmSphere of influence: experimental evolution of RNA virusesArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaMoratorio, GonzaloLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/31668/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-844http://localhost:8080/xmlui/bitstream/20.500.12008/31668/2/license_urla0ebbeafb9d2ec7cbb19d7137ebc392cMD52license_textlicense_texttext/html; charset=utf-838395http://localhost:8080/xmlui/bitstream/20.500.12008/31668/3/license_textd606c60c5d78967c4ed7a729e5bb402fMD53license_rdflicense_rdfapplication/rdf+xml; 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- Universidad de la Repúblicafalse
spellingShingle mSphere of influence: experimental evolution of RNA viruses
Moratorio, Gonzalo
Virus attenuation
Synthetic biology
Codon pair bias
Mutational robustness
status_str publishedVersion
title mSphere of influence: experimental evolution of RNA viruses
title_full mSphere of influence: experimental evolution of RNA viruses
title_fullStr mSphere of influence: experimental evolution of RNA viruses
title_full_unstemmed mSphere of influence: experimental evolution of RNA viruses
title_short mSphere of influence: experimental evolution of RNA viruses
title_sort mSphere of influence: experimental evolution of RNA viruses
topic Virus attenuation
Synthetic biology
Codon pair bias
Mutational robustness
url https://hdl.handle.net/20.500.12008/31668

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