mSphere of influence: experimental evolution of RNA viruses
Resumen:
Gonzalo Moratorio works in the field of experimental evolution of vi-ruses. In this mSphere of Influence article, he reflects on how the papers “Virus at-tenuation by genome-scale changes in codon pair bias” by Coleman et al. (Science320:1784–1787, 2008,https://doi.org/10.1126/science.1155761) and “Codon usage de-termines the mutational robustness, evolutionary capacity, and virulence of an RNAvirus” by Lauring et al. (Cell Host Microbe 12:623–632, 2012,https://doi.org/10.1016/j.chom.2012.10.008) made an impact on his thinking about how to employ syntheticbiology to study experimental evolution of viruses.
| 2020 | |
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Virus attenuation Synthetic biology Codon pair bias Mutational robustness |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/31668 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| Sumario: | Gonzalo Moratorio works in the field of experimental evolution of vi-ruses. In this mSphere of Influence article, he reflects on how the papers “Virus at-tenuation by genome-scale changes in codon pair bias” by Coleman et al. (Science320:1784–1787, 2008,https://doi.org/10.1126/science.1155761) and “Codon usage de-termines the mutational robustness, evolutionary capacity, and virulence of an RNAvirus” by Lauring et al. (Cell Host Microbe 12:623–632, 2012,https://doi.org/10.1016/j.chom.2012.10.008) made an impact on his thinking about how to employ syntheticbiology to study experimental evolution of viruses. |
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