Short-term surgical outcomes of rectal adenocarcinoma surgical treatment in Latin America: a multicenter, retrospective assessment in 49 centers from 12 countries
Resumen:
Introduction: Rectal cancer is a prevalent disease that requires multidisciplinary management. Results of treatment of patients suffering from this malignancy in Latin America have been scarcely reported before. Methods: A retrospective, multicenter study was conducted to report preoperative and operative characteristics of patients intervened for rectal cancer in centers from Latin America during 2015-2022, and the short-term results of treatment were analyzed. The study was open to any center receiving rectal cancer patients, irrespective of volume. The main study outcome was 30-day postoperative complications including any deviation from the normal postoperative course (Clavien Dindo I to V). Results: A total of 2044 patients from 49 centers in 12 Latin American countries were included, with a mean age of 63 years. Twenty-five percent of patients were operated in low-volume centers. Twenty-nine percent of patients had a tumor located in the low rectum, and only 53% of patients had preoperative MRI for local staging. A total of 1052 patients (52%) received neoadjuvant therapy before surgery. Eighty-six percent of patients were operated by a specialized colorectal surgeon, and 31% of patients were intervened using a conventional approach. A total of 29.9% of patients presented a postoperative complication. The anastomotic leak rate was 8.9%. Fifty-eight percent of pathology reports had less than 12 lymph nodes harvested, and 22.9% of reports did not include mesorectal quality. In the multivariate analysis, neoadjuvant therapy (OR: 1.44, p-value: 0.023), urgent procedures (OR: 3.73, p-value: 0.049), intraoperative complications (OR: 2.21, p-value: 0.046), advanced tumors (OR: 1.39, p-value: 0.036), and prolonged surgery (OR: 1.74, p-value: 0.004) were found to be independently related to suffering postoperative complications. Conclusions: This study includes information about the approach and results of rectal cancer management in Latin America at a large scale. In the future, this information can be used as a bridge to identify areas of improvement among rectal cancer patients' treatment in the region.
| 2024 | |
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Cancer Latin America Multidisciplinary Neoadjuvant Rectal ADENOCARCINOMA PATOLOGÍA PERSONA DE MEDIANA EDAD ANCIANO CIRUGÍA GENERAL HUMANOS EPIDEMIOLOGÍA COMPLICACIONES POSOPERATORIAS NEOPLASIAS DEL RECTO ESTUDIOS RETROSPECTIVOS FACTORES DE TIEMPO RESULTADO DEL TRATAMIENTO |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/56321 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| Sumario: | LATAM collaborative colorectal surgery consortium: Avellaneda Nicolas, Sebastian Valdivieso, Fabio Leiro, Marcos Gonzalez, Marcelo Viola Malet, Helio Moreira Junior, Reinaldo Isaacs, Eddy P Licango-Naranjo, Augusto Carrie, Gianluca Pellino, Spinelli Antonino, Antonio Caycedo-Marulanda, Mateo Santillán, Delfina Berasategui, Camila Bustamante Mayne, Martina Brun, Diana Alejandra Pantoja Pachajoa, Matías Parodi, Rosario Martiarena, Sergio Schlain, Camila Bras Harriott, Nicolas Rotholtz, Maximiliano Bun, Analía Inés Potolicchio, Yenny Quiroga, Federico Héctor Enrique Carballo, Pablo Farina, Carlos Vaccaro, Marcos González, Simón Sedziszow, Gaston Ortigueira, Tomas Seip, Oscar Dalzio Brosutti, María Soledad Cian, Fabio Oscar Leiro, Romina Bianchi, Julieta Yanet Espino Campagna, Mariela Cedermas, Pablo Arbios, Agustín Alesandrini, Juan Alberto Perriello, Javier Ignacio Villaggi, Florencia Barbero, Juan Manuel Giordanino, Gustavo Adrián Nari, Juan Pablo Muñoz, Natalia Mira Gesto, Federico Medina, Javier Santiago Minoldo, Gerardo Zanoni, Cristian Nicolas Lucas, Debra Nielsen, Juan Manuel Sotelo, Ana Inés Leone, Federico Posner, Diego Hernán Barletta, Christian Abel Ferrufino Méndez, Rogerio Serafim Parra, Fabio Lopes de Queiroz, Daniel Mauricio Londoño Estrada, Romulo Medeiros de Almeida, João Batista de Sousa, Bruno Augusto Alves Martins, Marcela Maria Silvino Craveiro, Rogerio Saad-Hossne, Augusto Antonio Barrera Zamorano, Alejandro Nicolas Barrera Escobar, Claudio Patricio Benavides Yáñez, Benedicto Misael Ocares Urzua, Francisco Xavier Báez Rojas, Tomas Sebastian Contreras Rivas, Felipe Bellolio Roth, Daniel Moreno Miranda, Christophe Riquoir Altamirano, Andrés Iglesias Bettini, Nelson Niño Puentes, María Sofia Labrador Morales, Juan Camilo Correa Cote, Gustavo Adolfo López, Daniela Sierra Castaño, Mauricio Gonzales Dorado, Andrés Ramiro Lanza Diaz, Víctor Hugo Bruno Cao, Jessica Capre Pereira, Rosana María Babilonia Yepes, Cristina Judith Padilla Herrera, Luis Eduardo Martínez López, Maikel Adolfo Pacheco Trujillo, Javier Ernesto Barreras González, Jorge Gerardo Pereira Fraga, Rafael Torres Peña, Miguel Ángel Martínez Alfonso, Silva Segovia David Renato, Francisco David Rivadeneira Proaño, Javier López-Gómez, Aldo Hernán Jaramillo Romero, Mario Alberto López Ramírez, Pablo Zeron Pontones, Ismael Brito Toledo, Michel Hernández Valadez, Adan Ramirez-Gaona, Josue Palacio Magaña, Roberto Ángel Núñez González, Marisol Solórzano Vanegas, María Alejandra Salazar Álvarez, Carlos Alberto Medina Diarte, Ruben Dominguez Azuaga, María Alejandra Pequeño Martínez, Marcelo Laurini Zanola, Alejandro Soumastre, Federico Duran, Alexandra Duffau Furini, Felix Luis Edgar Vásquez Chirinos, Sergio Antonio Martínez-Millán, Edibel Sabrina Vicent Vásquez, Maryeli Josefina Solorzano Vásquez |
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