Fluorescent labeled alpha-synuclein conformers for intracelular studies
Resumen:
Introduction: Alpha-synuclein (aS) is the major component of fibrillar aggregates within neurons in various neurodegenerative diseases, known as synucleinopathies. Cellular uptake of aS implies different unsolved mechanisms, thus is important to generate fluorescent aS species as an approach to study these processes and the interactions of aS in cellula . In this study, fluorescent aS species were generated by labeling monomer aS with Alexa488 fluorophore (Sigma-Aldrich Mix-n-StainTM CFTM 488TM). The use of fluorescent labeled aS will allow further studies on the mechanism that modulates the cellular uptake for the different aggregated species.
| 2025 | |
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ALFA-SINUCLEÍNA ENFERMEDADES NEURODEGENERATIVAS PROTEÍNAS COLORANTES FLUORESCENTES |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/53489 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| _version_ | 1877555214317256704 |
|---|---|
| author | Ivagnes, Rodrigo |
| author2 | Chavarría, Cecilia Souza, José M. |
| author2_role | author author |
| author_facet | Ivagnes, Rodrigo Chavarría, Cecilia Souza, José M. |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Ivagnes Rodrigo, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Bioquímica. Chavarría Cecilia, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Bioquímica. Souza José M., Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Bioquímica. |
| dc.creator.none.fl_str_mv | Ivagnes, Rodrigo Chavarría, Cecilia Souza, José M. |
| dc.date.accessioned.none.fl_str_mv | 2026-02-12T17:02:56Z |
| dc.date.available.none.fl_str_mv | 2026-02-12T17:02:56Z |
| dc.date.issued.none.fl_str_mv | 2025 |
| dc.description.abstract.none.fl_txt_mv | Introduction: Alpha-synuclein (aS) is the major component of fibrillar aggregates within neurons in various neurodegenerative diseases, known as synucleinopathies. Cellular uptake of aS implies different unsolved mechanisms, thus is important to generate fluorescent aS species as an approach to study these processes and the interactions of aS in cellula . In this study, fluorescent aS species were generated by labeling monomer aS with Alexa488 fluorophore (Sigma-Aldrich Mix-n-StainTM CFTM 488TM). The use of fluorescent labeled aS will allow further studies on the mechanism that modulates the cellular uptake for the different aggregated species. |
| dc.format.extent.es.fl_str_mv | 1 p. |
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| dc.identifier.citation.es.fl_str_mv | Ivagnes R, Chavarría C y Souza J. Fluorescent labeled alpha-synuclein conformers for intracelular studies [Poster]. En: 1st Patagonia Synuclein Workshop. 17-19 de noviembre 2025. Villa La Angostura, Neuquén, Argentina. |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/53489 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Udelar. FM |
| dc.relation.none.fl_str_mv | The Patagonia Synuclein Workshop 2025 |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.other.es.fl_str_mv | ALFA-SINUCLEÍNA ENFERMEDADES NEURODEGENERATIVAS PROTEÍNAS COLORANTES FLUORESCENTES |
| dc.title.none.fl_str_mv | Fluorescent labeled alpha-synuclein conformers for intracelular studies |
| dc.type.es.fl_str_mv | Póster |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/conferenceObject |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Introduction: Alpha-synuclein (aS) is the major component of fibrillar aggregates within neurons in various neurodegenerative diseases, known as synucleinopathies. Cellular uptake of aS implies different unsolved mechanisms, thus is important to generate fluorescent aS species as an approach to study these processes and the interactions of aS in cellula . In this study, fluorescent aS species were generated by labeling monomer aS with Alexa488 fluorophore (Sigma-Aldrich Mix-n-StainTM CFTM 488TM). The use of fluorescent labeled aS will allow further studies on the mechanism that modulates the cellular uptake for the different aggregated species. |
| eu_rights_str_mv | openAccess |
| format | conferenceObject |
| id | COLIBRI_564f942b9b746de5e95ccbf322f63d2e |
| identifier_str_mv | Ivagnes R, Chavarría C y Souza J. Fluorescent labeled alpha-synuclein conformers for intracelular studies [Poster]. En: 1st Patagonia Synuclein Workshop. 17-19 de noviembre 2025. Villa La Angostura, Neuquén, Argentina. |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/53489 |
| publishDate | 2025 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | karina.camps@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Ivagnes Rodrigo, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Bioquímica.Chavarría Cecilia, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Bioquímica.Souza José M., Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Bioquímica.2026-02-12T17:02:56Z2026-02-12T17:02:56Z2025Ivagnes R, Chavarría C y Souza J. Fluorescent labeled alpha-synuclein conformers for intracelular studies [Poster]. En: 1st Patagonia Synuclein Workshop. 17-19 de noviembre 2025. Villa La Angostura, Neuquén, Argentina.https://hdl.handle.net/20.500.12008/53489Introduction: Alpha-synuclein (aS) is the major component of fibrillar aggregates within neurons in various neurodegenerative diseases, known as synucleinopathies. Cellular uptake of aS implies different unsolved mechanisms, thus is important to generate fluorescent aS species as an approach to study these processes and the interactions of aS in cellula . In this study, fluorescent aS species were generated by labeling monomer aS with Alexa488 fluorophore (Sigma-Aldrich Mix-n-StainTM CFTM 488TM). The use of fluorescent labeled aS will allow further studies on the mechanism that modulates the cellular uptake for the different aggregated species.Submitted by Bonino Ferreira María Eugenia (eubonny@gmail.com) on 2026-02-12T12:03:27Z No. of bitstreams: 2 license_rdf: 27293 bytes, checksum: d62648cf14c1e37917d392ac87012955 (MD5) Fluorescent Labeled alpha synuclein Conformers for Intracellular Studies.pdf: 1784387 bytes, checksum: d8feed2635bf55f41047b58852728838 (MD5)Approved for entry into archive by Almiñana María Cecilia (marialminana@gmail.com) on 2026-02-12T12:47:23Z (GMT) No. of bitstreams: 2 license_rdf: 27293 bytes, checksum: d62648cf14c1e37917d392ac87012955 (MD5) Fluorescent Labeled alpha synuclein Conformers for Intracellular Studies.pdf: 1784387 bytes, checksum: d8feed2635bf55f41047b58852728838 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2026-02-12T17:02:56Z (GMT). No. of bitstreams: 2 license_rdf: 27293 bytes, checksum: d62648cf14c1e37917d392ac87012955 (MD5) Fluorescent Labeled alpha synuclein Conformers for Intracellular Studies.pdf: 1784387 bytes, checksum: d8feed2635bf55f41047b58852728838 (MD5) Previous issue date: 20251 p.application/pdfenengUdelar. FMThe Patagonia Synuclein Workshop 2025Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)ALFA-SINUCLEÍNAENFERMEDADES NEURODEGENERATIVASPROTEÍNASCOLORANTES FLUORESCENTESFluorescent labeled alpha-synuclein conformers for intracelular studiesPósterinfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaIvagnes, RodrigoChavarría, CeciliaSouza, José M.LICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/53489/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-850http://localhost:8080/xmlui/bitstream/20.500.12008/53489/2/license_urla006180e3f5b2ad0b88185d14284c0e0MD52license_textlicense_texttext/html; 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- Universidad de la Repúblicafalse |
| spellingShingle | Fluorescent labeled alpha-synuclein conformers for intracelular studies Ivagnes, Rodrigo ALFA-SINUCLEÍNA ENFERMEDADES NEURODEGENERATIVAS PROTEÍNAS COLORANTES FLUORESCENTES |
| status_str | publishedVersion |
| title | Fluorescent labeled alpha-synuclein conformers for intracelular studies |
| title_full | Fluorescent labeled alpha-synuclein conformers for intracelular studies |
| title_fullStr | Fluorescent labeled alpha-synuclein conformers for intracelular studies |
| title_full_unstemmed | Fluorescent labeled alpha-synuclein conformers for intracelular studies |
| title_short | Fluorescent labeled alpha-synuclein conformers for intracelular studies |
| title_sort | Fluorescent labeled alpha-synuclein conformers for intracelular studies |
| topic | ALFA-SINUCLEÍNA ENFERMEDADES NEURODEGENERATIVAS PROTEÍNAS COLORANTES FLUORESCENTES |
| url | https://hdl.handle.net/20.500.12008/53489 |
