Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis
Resumen:
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive death of motor neurons and muscle atrophy, with defective neuron-glia interplay and emergence of aberrant glial phenotypes having a role in disease pathology. Here, we have studied if the pigment violacein with several reported protective/antiproliferative properties may control highly neurotoxic astrocytes (AbAs) obtained from spinal cord cultures of symptomatic hSOD1G93A rats, and if it could be neuroprotective in this ALS experimental model. At concentrations lower than those reported as protective, violacein selectively killed aberrant astrocytes. Treatment of hSOD1G93A rats with doses equivalent to the concentrations that killed AbAs caused a marginally significant delay in survival, partially preserved the body weight and soleus muscle mass and improved the integrity of the neuromuscular junction. Reduced motor neuron death and glial reactivity was also found and likely related to decreased inflammation and matrix metalloproteinase-2 and -9. Thus, in spite that new experimental designs aimed at extending the lifespan of hSOD1G93A rats are needed, improvements observed upon violacein treatment suggest a significant therapeutic potential that deserves further studies.
| 2022 | |
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ESCLEROSIS AMIOTRÓFICA LATERAL ADMINISTRACIÓN DEL TRATAMIENTO FARMACOLÓGICO GENÉTICA ANIMALES MODELOS ANIMALES DE ENFERMEDAD INDOLES METALOPROTEINASA 2 DE LA MATRIZ RATONES TRANSGÉNICOS NEURONAS MOTORAS PATOLOGÍA CLÍNICA FARMACOLOGÍA ENFERMEDADES NEURODEGENERATIVAS RATAS FÁRMACOS NEUROPROTECTORES USOS TERAPÉUTICOS MÉDULA ESPINAL |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/54513 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1875692823073783808 |
|---|---|
| author | Olivares-Bravo, Silvia |
| author2 | Bolatto, Carmen Otero Damianovich, Gabriel Stancov, Matías Cerri, Sofía Rodríguez, Paola Boragno, Daniela Hernández Mir, Karina Cuitiño, María Noel Larrambembere, Fernanda Isasi, Eugenia Alem, Diego Canclini, Lucía Marco, Marta Davyt, Danilo Díaz-Amarilla, Pablo |
| author2_role | author author author author author author author author author author author author author author author |
| author_facet | Olivares-Bravo, Silvia Bolatto, Carmen Otero Damianovich, Gabriel Stancov, Matías Cerri, Sofía Rodríguez, Paola Boragno, Daniela Hernández Mir, Karina Cuitiño, María Noel Larrambembere, Fernanda Isasi, Eugenia Alem, Diego Canclini, Lucía Marco, Marta Davyt, Danilo Díaz-Amarilla, Pablo |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Olivares-Bravo Silvia, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y Molecular Bolatto Carmen, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Histología y Embriología Otero Damianovich Gabriel, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y Molecular Stancov Matías, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y Molecular Cerri Sofía, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Histología y Embriología Rodríguez Paola, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y Molecular Boragno Daniela, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y Molecular Hernández Mir Karina, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Histología y Embriología Cuitiño María Noel, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y Molecular Larrambembere Fernanda, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y Molecular Isasi Eugenia, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Histología y Embriología Alem Diego, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Departamento de Genética Canclini Lucía, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Departamento de Genética Marco Marta, Universidad de la República (Uruguay). Facultad de Química. Departamento de Bioquímica Clínica Davyt Danilo, Universidad de la República (Uruguay). Facultad de Química. Laboratorio de Química Farmacéutica Díaz-Amarilla Pablo, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y Molecular |
| dc.creator.none.fl_str_mv | Olivares-Bravo, Silvia Bolatto, Carmen Otero Damianovich, Gabriel Stancov, Matías Cerri, Sofía Rodríguez, Paola Boragno, Daniela Hernández Mir, Karina Cuitiño, María Noel Larrambembere, Fernanda Isasi, Eugenia Alem, Diego Canclini, Lucía Marco, Marta Davyt, Danilo Díaz-Amarilla, Pablo |
| dc.date.accessioned.none.fl_str_mv | 2026-04-21T15:59:31Z |
| dc.date.available.none.fl_str_mv | 2026-04-21T15:59:31Z |
| dc.date.issued.none.fl_str_mv | 2022 |
| dc.description.abstract.none.fl_txt_mv | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive death of motor neurons and muscle atrophy, with defective neuron-glia interplay and emergence of aberrant glial phenotypes having a role in disease pathology. Here, we have studied if the pigment violacein with several reported protective/antiproliferative properties may control highly neurotoxic astrocytes (AbAs) obtained from spinal cord cultures of symptomatic hSOD1G93A rats, and if it could be neuroprotective in this ALS experimental model. At concentrations lower than those reported as protective, violacein selectively killed aberrant astrocytes. Treatment of hSOD1G93A rats with doses equivalent to the concentrations that killed AbAs caused a marginally significant delay in survival, partially preserved the body weight and soleus muscle mass and improved the integrity of the neuromuscular junction. Reduced motor neuron death and glial reactivity was also found and likely related to decreased inflammation and matrix metalloproteinase-2 and -9. Thus, in spite that new experimental designs aimed at extending the lifespan of hSOD1G93A rats are needed, improvements observed upon violacein treatment suggest a significant therapeutic potential that deserves further studies. |
| dc.format.extent.es.fl_str_mv | 19 p. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Olivares-Bravo S, Bolatto C, Otero Damianovich G y otros. Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis. Scientific Reports [en línea]. 2022;12(1). 19 p. |
| dc.identifier.doi.none.fl_str_mv | 10.1038/s41598-022-06470-7 |
| dc.identifier.eissn.none.fl_str_mv | 2045-2322 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/54513 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Nature Portfolio |
| dc.relation.none.fl_str_mv | Scientific Reports. 2022;12(1) |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.other.es.fl_str_mv | ESCLEROSIS AMIOTRÓFICA LATERAL ADMINISTRACIÓN DEL TRATAMIENTO FARMACOLÓGICO GENÉTICA ANIMALES MODELOS ANIMALES DE ENFERMEDAD INDOLES METALOPROTEINASA 2 DE LA MATRIZ RATONES TRANSGÉNICOS NEURONAS MOTORAS PATOLOGÍA CLÍNICA FARMACOLOGÍA ENFERMEDADES NEURODEGENERATIVAS RATAS FÁRMACOS NEUROPROTECTORES USOS TERAPÉUTICOS MÉDULA ESPINAL |
| dc.title.none.fl_str_mv | Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive death of motor neurons and muscle atrophy, with defective neuron-glia interplay and emergence of aberrant glial phenotypes having a role in disease pathology. Here, we have studied if the pigment violacein with several reported protective/antiproliferative properties may control highly neurotoxic astrocytes (AbAs) obtained from spinal cord cultures of symptomatic hSOD1G93A rats, and if it could be neuroprotective in this ALS experimental model. At concentrations lower than those reported as protective, violacein selectively killed aberrant astrocytes. Treatment of hSOD1G93A rats with doses equivalent to the concentrations that killed AbAs caused a marginally significant delay in survival, partially preserved the body weight and soleus muscle mass and improved the integrity of the neuromuscular junction. Reduced motor neuron death and glial reactivity was also found and likely related to decreased inflammation and matrix metalloproteinase-2 and -9. Thus, in spite that new experimental designs aimed at extending the lifespan of hSOD1G93A rats are needed, improvements observed upon violacein treatment suggest a significant therapeutic potential that deserves further studies. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_52e93d098b34cc7fec6b3a03a5b3eb64 |
| identifier_str_mv | Olivares-Bravo S, Bolatto C, Otero Damianovich G y otros. Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis. Scientific Reports [en línea]. 2022;12(1). 19 p. 10.1038/s41598-022-06470-7 2045-2322 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/54513 |
| publishDate | 2022 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | karina.camps@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Olivares-Bravo Silvia, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y MolecularBolatto Carmen, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Histología y EmbriologíaOtero Damianovich Gabriel, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y MolecularStancov Matías, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y MolecularCerri Sofía, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Histología y EmbriologíaRodríguez Paola, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y MolecularBoragno Daniela, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y MolecularHernández Mir Karina, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Histología y EmbriologíaCuitiño María Noel, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y MolecularLarrambembere Fernanda, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y MolecularIsasi Eugenia, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Histología y EmbriologíaAlem Diego, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Departamento de GenéticaCanclini Lucía, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Departamento de GenéticaMarco Marta, Universidad de la República (Uruguay). Facultad de Química. Departamento de Bioquímica ClínicaDavyt Danilo, Universidad de la República (Uruguay). Facultad de Química. Laboratorio de Química FarmacéuticaDíaz-Amarilla Pablo, Instituto de Investigaciones Biológicas Clemente Estable (Uruguay). Laboratorio de Neurobiología Celular y Molecular2026-04-21T15:59:31Z2026-04-21T15:59:31Z2022Olivares-Bravo S, Bolatto C, Otero Damianovich G y otros. Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis. Scientific Reports [en línea]. 2022;12(1). 19 p.https://hdl.handle.net/20.500.12008/5451310.1038/s41598-022-06470-72045-2322Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive death of motor neurons and muscle atrophy, with defective neuron-glia interplay and emergence of aberrant glial phenotypes having a role in disease pathology. Here, we have studied if the pigment violacein with several reported protective/antiproliferative properties may control highly neurotoxic astrocytes (AbAs) obtained from spinal cord cultures of symptomatic hSOD1G93A rats, and if it could be neuroprotective in this ALS experimental model. At concentrations lower than those reported as protective, violacein selectively killed aberrant astrocytes. Treatment of hSOD1G93A rats with doses equivalent to the concentrations that killed AbAs caused a marginally significant delay in survival, partially preserved the body weight and soleus muscle mass and improved the integrity of the neuromuscular junction. Reduced motor neuron death and glial reactivity was also found and likely related to decreased inflammation and matrix metalloproteinase-2 and -9. Thus, in spite that new experimental designs aimed at extending the lifespan of hSOD1G93A rats are needed, improvements observed upon violacein treatment suggest a significant therapeutic potential that deserves further studies.Submitted by Almiñana María Cecilia (marialminana@gmail.com) on 2026-04-21T13:27:22Z No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis.pdf: 10357101 bytes, checksum: 09b535325b27cc84ccd191e223afe988 (MD5)Approved for entry into archive by Almiñana María Cecilia (marialminana@gmail.com) on 2026-04-21T15:51:26Z (GMT) No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis.pdf: 10357101 bytes, checksum: 09b535325b27cc84ccd191e223afe988 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2026-04-21T15:59:31Z (GMT). No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis.pdf: 10357101 bytes, checksum: 09b535325b27cc84ccd191e223afe988 (MD5) Previous issue date: 202219 p.application/pdfenengNature PortfolioScientific Reports. 2022;12(1)Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)ESCLEROSIS AMIOTRÓFICA LATERALADMINISTRACIÓN DEL TRATAMIENTO FARMACOLÓGICOGENÉTICAANIMALESMODELOS ANIMALES DE ENFERMEDADINDOLESMETALOPROTEINASA 2 DE LA MATRIZRATONES TRANSGÉNICOSNEURONAS MOTORASPATOLOGÍA CLÍNICAFARMACOLOGÍAENFERMEDADES NEURODEGENERATIVASRATASFÁRMACOS NEUROPROTECTORESUSOS TERAPÉUTICOSMÉDULA ESPINALNeuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosisArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaOlivares-Bravo, SilviaBolatto, CarmenOtero Damianovich, GabrielStancov, MatíasCerri, SofíaRodríguez, PaolaBoragno, DanielaHernández Mir, KarinaCuitiño, María NoelLarrambembere, FernandaIsasi, EugeniaAlem, DiegoCanclini, LucíaMarco, MartaDavyt, DaniloDíaz-Amarilla, PabloLICENSElicense.txtlicense.txttext/plain; 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- Universidad de la Repúblicafalse |
| spellingShingle | Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis Olivares-Bravo, Silvia ESCLEROSIS AMIOTRÓFICA LATERAL ADMINISTRACIÓN DEL TRATAMIENTO FARMACOLÓGICO GENÉTICA ANIMALES MODELOS ANIMALES DE ENFERMEDAD INDOLES METALOPROTEINASA 2 DE LA MATRIZ RATONES TRANSGÉNICOS NEURONAS MOTORAS PATOLOGÍA CLÍNICA FARMACOLOGÍA ENFERMEDADES NEURODEGENERATIVAS RATAS FÁRMACOS NEUROPROTECTORES USOS TERAPÉUTICOS MÉDULA ESPINAL |
| status_str | publishedVersion |
| title | Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis |
| title_full | Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis |
| title_fullStr | Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis |
| title_full_unstemmed | Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis |
| title_short | Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis |
| title_sort | Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis |
| topic | ESCLEROSIS AMIOTRÓFICA LATERAL ADMINISTRACIÓN DEL TRATAMIENTO FARMACOLÓGICO GENÉTICA ANIMALES MODELOS ANIMALES DE ENFERMEDAD INDOLES METALOPROTEINASA 2 DE LA MATRIZ RATONES TRANSGÉNICOS NEURONAS MOTORAS PATOLOGÍA CLÍNICA FARMACOLOGÍA ENFERMEDADES NEURODEGENERATIVAS RATAS FÁRMACOS NEUROPROTECTORES USOS TERAPÉUTICOS MÉDULA ESPINAL |
| url | https://hdl.handle.net/20.500.12008/54513 |
