Blood matters: the hematological signatures of Coronavirus infection
Resumen:
Recent developments have broadened our perception of SARS-CoV-2, indicating its capability to affect the body systemically beyond its initial recognition as a mere respiratory pathogen. However, the pathways of its widespread are not well understood. Employing a dual-modality approach, we integrated findings from a Murine Hepatitis Virus (MHV) infection model with corroborative clinical data to investigate the pervasive reach of Coronaviruses. The novel presence of viral particles within red blood cells (RBCs) was demonstrated via high-resolution transmission electron microscopy, with computational modeling elucidating a potential heme-mediated viral entry mechanism via Spike protein affinity. Our data affirm viral localization in RBCs, suggesting heme moieties as facilitators for cellular invasion. Exacerbation of MHV pathology upon hemin administration, contrasted with chloroquine-mediated amelioration, underscoring a heme-centric pathway in disease progression. These observations extend the paradigm of Coronavirus pathogenicity to include hemoprotein interactions. This study casts new light on the systemic invasion capabilities of Coronaviruses, linking RBC hemoproteins with viral virulence. The modulation of disease severity through hemeinteracting agents heralds a promising avenue for COVID-19 therapeutics. Our findings propose a paradigm shift in the treatment approach, leveraging the virus-heme interplay as a strategic hinge for intervention
| 2024 | |
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Infection Viral infection SARS-CoV-2 |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/49606 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1872864698083311616 |
|---|---|
| author | Toro, Ayelen |
| author2 | Arévalo, Ana Paula Pereira-Gómez, Marianoel Sabater, Agustina Zizzi, Eric A. Perbolianachis Duarte, Paula Pascual, Gastón Lage-Vickers, Sofia Pórfido Barayoli, Jorge Luis Achinelli, Ines Seniuk, Rocio Bizzotto, Juan Sanchis, Pablo Olivera, Álvaro Leyva, Alejandro Moreno Karlen, María del Pilar Costábile Cristech, Alicia Fajardo Rossi, Álvaro Carrión Runco, Federico Daniel Fló Díaz, Martín Olivero-Deibe, Natalia Rodríguez, Fernando Nin, Nicolás Anselmino, Nicolás Labanca, Estefania Vazquez, Elba Cotignola, Javier Alonso, Daniel F. Marti, Marcelo Valacco, María Pía Gentile, Francesco Cherkasov, Artem Crispo, Martina Moratorio, Gonzalo Gueron, Geraldine |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Toro, Ayelen Arévalo, Ana Paula Pereira-Gómez, Marianoel Sabater, Agustina Zizzi, Eric A. Perbolianachis Duarte, Paula Pascual, Gastón Lage-Vickers, Sofia Pórfido Barayoli, Jorge Luis Achinelli, Ines Seniuk, Rocio Bizzotto, Juan Sanchis, Pablo Olivera, Álvaro Leyva, Alejandro Moreno Karlen, María del Pilar Costábile Cristech, Alicia Fajardo Rossi, Álvaro Carrión Runco, Federico Daniel Fló Díaz, Martín Olivero-Deibe, Natalia Rodríguez, Fernando Nin, Nicolás Anselmino, Nicolás Labanca, Estefania Vazquez, Elba Cotignola, Javier Alonso, Daniel F. Marti, Marcelo Valacco, María Pía Gentile, Francesco Cherkasov, Artem Crispo, Martina Moratorio, Gonzalo Gueron, Geraldine |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Toro Ayelen, Universidad de Buenos Aires. Arévalo Ana Paula, Instituto Pasteur (Montevideo). Pereira-Gómez Marianoel, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Sabater Agustina, Universidad de Buenos Aires. Zizzi Eric A., Politecnico di Torino. Perbolianachis Duarte Paula, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Pascual Gastón, Universidad de Buenos Aires. Lage-Vickers Sofia, Universidad de Buenos Aires. Pórfido Barayoli Jorge Luis, Instituto Pasteur (Montevideo). Achinelli Ines, Universidad de Buenos Aires. Seniuk Rocio, Universidad de Buenos Aires. Bizzotto Juan, Universidad de Buenos Aires. Sanchis Pablo, Universidad de Buenos Aires. Olivera Álvaro, Universidad de la República (Uruguay). Facultad de Ciencias. CURE. Leyva Alejandro, IIBCE Moreno Karlen María del Pilar, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Costábile Cristech Alicia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Fajardo Rossi Álvaro, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Carrión Runco Federico Daniel, Instituto Pasteur (Montevideo). Fló Díaz Martín, Instituto Pasteur (Montevideo). Olivero-Deibe Natalia, Instituto Pasteur (Montevideo). Rodríguez Fernando, ASSE Nin Nicolas, ASSE Anselmino Nicolas, University of Texas. Labanca Estefania, University of Texas. Vazquez Elba, Universidad de Buenos Aires. Cotignola Javier, Universidad de Buenos Aires. Alonso Daniel F., Universidad Nacional de Quilmes. Marti Marcelo, Universidad de Buenos Aires. Valacco María Pía, Universidad de Buenos Aires. Gentile Francesco, University of Ottawa. Cherkasov Artem, University of British Columbia. Crispo Martina, Instituto Pasteur (Montevideo). Moratorio Gonzalo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Gueron Geraldine, Universidad de Buenos Aires. |
| dc.creator.none.fl_str_mv | Toro, Ayelen Arévalo, Ana Paula Pereira-Gómez, Marianoel Sabater, Agustina Zizzi, Eric A. Perbolianachis Duarte, Paula Pascual, Gastón Lage-Vickers, Sofia Pórfido Barayoli, Jorge Luis Achinelli, Ines Seniuk, Rocio Bizzotto, Juan Sanchis, Pablo Olivera, Álvaro Leyva, Alejandro Moreno Karlen, María del Pilar Costábile Cristech, Alicia Fajardo Rossi, Álvaro Carrión Runco, Federico Daniel Fló Díaz, Martín Olivero-Deibe, Natalia Rodríguez, Fernando Nin, Nicolás Anselmino, Nicolás Labanca, Estefania Vazquez, Elba Cotignola, Javier Alonso, Daniel F. Marti, Marcelo Valacco, María Pía Gentile, Francesco Cherkasov, Artem Crispo, Martina Moratorio, Gonzalo Gueron, Geraldine |
| dc.date.accessioned.none.fl_str_mv | 2025-04-04T16:13:46Z |
| dc.date.available.none.fl_str_mv | 2025-04-04T16:13:46Z |
| dc.date.issued.none.fl_str_mv | 2024 |
| dc.description.abstract.none.fl_txt_mv | Recent developments have broadened our perception of SARS-CoV-2, indicating its capability to affect the body systemically beyond its initial recognition as a mere respiratory pathogen. However, the pathways of its widespread are not well understood. Employing a dual-modality approach, we integrated findings from a Murine Hepatitis Virus (MHV) infection model with corroborative clinical data to investigate the pervasive reach of Coronaviruses. The novel presence of viral particles within red blood cells (RBCs) was demonstrated via high-resolution transmission electron microscopy, with computational modeling elucidating a potential heme-mediated viral entry mechanism via Spike protein affinity. Our data affirm viral localization in RBCs, suggesting heme moieties as facilitators for cellular invasion. Exacerbation of MHV pathology upon hemin administration, contrasted with chloroquine-mediated amelioration, underscoring a heme-centric pathway in disease progression. These observations extend the paradigm of Coronavirus pathogenicity to include hemoprotein interactions. This study casts new light on the systemic invasion capabilities of Coronaviruses, linking RBC hemoproteins with viral virulence. The modulation of disease severity through hemeinteracting agents heralds a promising avenue for COVID-19 therapeutics. Our findings propose a paradigm shift in the treatment approach, leveraging the virus-heme interplay as a strategic hinge for intervention |
| dc.description.es.fl_txt_mv | Información suplementaria en: 10.1038/s41419-024-07247-8. |
| dc.format.extent.es.fl_str_mv | 13 h |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Toro, A, Arévalo, A, Pereira-Gómez, M [y otros autores]. "Blood matters: the hematological signatures of Coronavirus infection". Cell Death and Disease. [en línea] 2024, 15: 863. 13 h. DOI: 10.1038/s41419-024-07247-8 |
| dc.identifier.doi.none.fl_str_mv | 10.1038/s41419-024-07247-8 |
| dc.identifier.issn.none.fl_str_mv | 2041-4889 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/49606 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Nature |
| dc.relation.none.fl_str_mv | Cell Death and Disease, 2024, 15: 863. |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Infection Viral infection SARS-CoV-2 |
| dc.title.none.fl_str_mv | Blood matters: the hematological signatures of Coronavirus infection |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Información suplementaria en: 10.1038/s41419-024-07247-8. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_4fc8bee74afb886b5617a3e6fe7ccfc5 |
| identifier_str_mv | Toro, A, Arévalo, A, Pereira-Gómez, M [y otros autores]. "Blood matters: the hematological signatures of Coronavirus infection". Cell Death and Disease. [en línea] 2024, 15: 863. 13 h. DOI: 10.1038/s41419-024-07247-8 2041-4889 10.1038/s41419-024-07247-8 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/49606 |
| publishDate | 2024 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | karina.camps@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Toro Ayelen, Universidad de Buenos Aires.Arévalo Ana Paula, Instituto Pasteur (Montevideo).Pereira-Gómez Marianoel, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Sabater Agustina, Universidad de Buenos Aires.Zizzi Eric A., Politecnico di Torino.Perbolianachis Duarte Paula, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Pascual Gastón, Universidad de Buenos Aires.Lage-Vickers Sofia, Universidad de Buenos Aires.Pórfido Barayoli Jorge Luis, Instituto Pasteur (Montevideo).Achinelli Ines, Universidad de Buenos Aires.Seniuk Rocio, Universidad de Buenos Aires.Bizzotto Juan, Universidad de Buenos Aires.Sanchis Pablo, Universidad de Buenos Aires.Olivera Álvaro, Universidad de la República (Uruguay). Facultad de Ciencias. CURE.Leyva Alejandro, IIBCEMoreno Karlen María del Pilar, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Costábile Cristech Alicia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Fajardo Rossi Álvaro, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Carrión Runco Federico Daniel, Instituto Pasteur (Montevideo).Fló Díaz Martín, Instituto Pasteur (Montevideo).Olivero-Deibe Natalia, Instituto Pasteur (Montevideo).Rodríguez Fernando, ASSENin Nicolas, ASSEAnselmino Nicolas, University of Texas.Labanca Estefania, University of Texas.Vazquez Elba, Universidad de Buenos Aires.Cotignola Javier, Universidad de Buenos Aires.Alonso Daniel F., Universidad Nacional de Quilmes.Marti Marcelo, Universidad de Buenos Aires.Valacco María Pía, Universidad de Buenos Aires.Gentile Francesco, University of Ottawa.Cherkasov Artem, University of British Columbia.Crispo Martina, Instituto Pasteur (Montevideo).Moratorio Gonzalo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Gueron Geraldine, Universidad de Buenos Aires.2025-04-04T16:13:46Z2025-04-04T16:13:46Z2024Toro, A, Arévalo, A, Pereira-Gómez, M [y otros autores]. "Blood matters: the hematological signatures of Coronavirus infection". Cell Death and Disease. [en línea] 2024, 15: 863. 13 h. DOI: 10.1038/s41419-024-07247-82041-4889https://hdl.handle.net/20.500.12008/4960610.1038/s41419-024-07247-8Información suplementaria en: 10.1038/s41419-024-07247-8.Recent developments have broadened our perception of SARS-CoV-2, indicating its capability to affect the body systemically beyond its initial recognition as a mere respiratory pathogen. However, the pathways of its widespread are not well understood. Employing a dual-modality approach, we integrated findings from a Murine Hepatitis Virus (MHV) infection model with corroborative clinical data to investigate the pervasive reach of Coronaviruses. The novel presence of viral particles within red blood cells (RBCs) was demonstrated via high-resolution transmission electron microscopy, with computational modeling elucidating a potential heme-mediated viral entry mechanism via Spike protein affinity. Our data affirm viral localization in RBCs, suggesting heme moieties as facilitators for cellular invasion. Exacerbation of MHV pathology upon hemin administration, contrasted with chloroquine-mediated amelioration, underscoring a heme-centric pathway in disease progression. These observations extend the paradigm of Coronavirus pathogenicity to include hemoprotein interactions. This study casts new light on the systemic invasion capabilities of Coronaviruses, linking RBC hemoproteins with viral virulence. The modulation of disease severity through hemeinteracting agents heralds a promising avenue for COVID-19 therapeutics. Our findings propose a paradigm shift in the treatment approach, leveraging the virus-heme interplay as a strategic hinge for interventionSubmitted by Pintos Natalia (nataliapintosmvd@gmail.com) on 2025-04-04T14:39:53Z No. of bitstreams: 2 license_rdf: 24942 bytes, checksum: 58cb336ce230a47d2f88ad02838a665f (MD5) 10.1038-s41419-024-07247-8.pdf: 5692199 bytes, checksum: 49dc2ccc4923ea17481c75d8c870203a (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2025-04-04T14:57:07Z (GMT) No. of bitstreams: 2 license_rdf: 24942 bytes, checksum: 58cb336ce230a47d2f88ad02838a665f (MD5) 10.1038-s41419-024-07247-8.pdf: 5692199 bytes, checksum: 49dc2ccc4923ea17481c75d8c870203a (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2025-04-04T16:13:46Z (GMT). No. of bitstreams: 2 license_rdf: 24942 bytes, checksum: 58cb336ce230a47d2f88ad02838a665f (MD5) 10.1038-s41419-024-07247-8.pdf: 5692199 bytes, checksum: 49dc2ccc4923ea17481c75d8c870203a (MD5) Previous issue date: 202413 happlication/pdfenengNatureCell Death and Disease, 2024, 15: 863.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)InfectionViral infectionSARS-CoV-2Blood matters: the hematological signatures of Coronavirus infectionArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaToro, AyelenArévalo, Ana PaulaPereira-Gómez, MarianoelSabater, AgustinaZizzi, Eric A.Perbolianachis Duarte, PaulaPascual, GastónLage-Vickers, SofiaPórfido Barayoli, Jorge LuisAchinelli, InesSeniuk, RocioBizzotto, JuanSanchis, PabloOlivera, ÁlvaroLeyva, AlejandroMoreno Karlen, María del PilarCostábile Cristech, AliciaFajardo Rossi, ÁlvaroCarrión Runco, Federico DanielFló Díaz, MartínOlivero-Deibe, NataliaRodríguez, FernandoNin, NicolásAnselmino, NicolásLabanca, EstefaniaVazquez, ElbaCotignola, JavierAlonso, Daniel F.Marti, MarceloValacco, María PíaGentile, FrancescoCherkasov, ArtemCrispo, MartinaMoratorio, 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públicahttps://udelar.edu.uy/https://www.colibri.udelar.edu.uy/oai/requestkarina.camps@seciu.edu.uyUruguayopendoar:47712025-05-29T14:13:47COLIBRI - Universidad de la Repúblicafalse |
| spellingShingle | Blood matters: the hematological signatures of Coronavirus infection Toro, Ayelen Infection Viral infection SARS-CoV-2 |
| status_str | publishedVersion |
| title | Blood matters: the hematological signatures of Coronavirus infection |
| title_full | Blood matters: the hematological signatures of Coronavirus infection |
| title_fullStr | Blood matters: the hematological signatures of Coronavirus infection |
| title_full_unstemmed | Blood matters: the hematological signatures of Coronavirus infection |
| title_short | Blood matters: the hematological signatures of Coronavirus infection |
| title_sort | Blood matters: the hematological signatures of Coronavirus infection |
| topic | Infection Viral infection SARS-CoV-2 |
| url | https://hdl.handle.net/20.500.12008/49606 |
