An ANOVA approach for statistical comparisons of brain networks
Resumen:
The study of brain networks has developed extensively over the last couple of decades. By contrast, techniques for the statistical analysis of these networks are less developed. In this paper, we focus on the statistical comparison of brain networks in a nonparametric framework and discuss the associated detection and identification problems. We tested network differences between groups with an analysis of variance (ANOVA) test we developed specifically for networks. We also propose and analyse the behaviour of a new statistical procedure designed to identify different subnetworks. As an example, we show the application of this tool in resting-state fMRI data obtained from the Human Connectome Project. We identify, among other variables, that the amount of sleep the days before the scan is a relevant variable that must be controlled. Finally, we discuss the potential bias in neuroimaging findings that is generated by some behavioural and brain structure variables. Our method can also be applied to other kind of networks such as protein interaction networks, gene networks or social networks.
2018 | |
Analysis of variance Brain Neuroimaging Social network |
|
Inglés | |
Universidad de la República | |
COLIBRI | |
https://hdl.handle.net/20.500.12008/21998 | |
Acceso abierto | |
Licencia Creative Commons Atribución (CC –BY 4.0) |
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---|---|
author | Fraiman, D |
author2 | Fraiman, Ricardo |
author2_role | author |
author_facet | Fraiman, D Fraiman, Ricardo |
author_role | author |
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collection | COLIBRI |
dc.contributor.filiacion.es.fl_str_mv | Fraiman, Ricardo. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Matemática. |
dc.creator.none.fl_str_mv | Fraiman, D Fraiman, Ricardo |
dc.date.accessioned.none.fl_str_mv | 2019-10-02T22:08:21Z |
dc.date.available.none.fl_str_mv | 2019-10-02T22:08:21Z |
dc.date.issued.es.fl_str_mv | 2018 |
dc.date.submitted.es.fl_str_mv | 20190930 |
dc.description.abstract.none.fl_txt_mv | The study of brain networks has developed extensively over the last couple of decades. By contrast, techniques for the statistical analysis of these networks are less developed. In this paper, we focus on the statistical comparison of brain networks in a nonparametric framework and discuss the associated detection and identification problems. We tested network differences between groups with an analysis of variance (ANOVA) test we developed specifically for networks. We also propose and analyse the behaviour of a new statistical procedure designed to identify different subnetworks. As an example, we show the application of this tool in resting-state fMRI data obtained from the Human Connectome Project. We identify, among other variables, that the amount of sleep the days before the scan is a relevant variable that must be controlled. Finally, we discuss the potential bias in neuroimaging findings that is generated by some behavioural and brain structure variables. Our method can also be applied to other kind of networks such as protein interaction networks, gene networks or social networks. |
dc.format.mimetype.es.fl_str_mv | application/pdf |
dc.identifier.citation.es.fl_str_mv | Fraiman, D., Fraiman, R. "An ANOVA approach for statistical comparisons of brain networks". Scientific Reports, 2018, 8: 4746. doi: 10.1038/s41598-018-23152-5 |
dc.identifier.doi.es.fl_str_mv | 10.1038/s41598-018-23152-5 |
dc.identifier.issn.es.fl_str_mv | 2045-2322 |
dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/21998 |
dc.language.iso.none.fl_str_mv | en eng |
dc.publisher.es.fl_str_mv | Nature Publishing Group |
dc.relation.ispartof.es.fl_str_mv | Scientific Reports, 2018, 8, art. no. 4746 |
dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC –BY 4.0) |
dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
dc.subject.es.fl_str_mv | Analysis of variance Brain Neuroimaging Social network |
dc.title.none.fl_str_mv | An ANOVA approach for statistical comparisons of brain networks |
dc.type.es.fl_str_mv | Artículo |
dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
description | The study of brain networks has developed extensively over the last couple of decades. By contrast, techniques for the statistical analysis of these networks are less developed. In this paper, we focus on the statistical comparison of brain networks in a nonparametric framework and discuss the associated detection and identification problems. We tested network differences between groups with an analysis of variance (ANOVA) test we developed specifically for networks. We also propose and analyse the behaviour of a new statistical procedure designed to identify different subnetworks. As an example, we show the application of this tool in resting-state fMRI data obtained from the Human Connectome Project. We identify, among other variables, that the amount of sleep the days before the scan is a relevant variable that must be controlled. Finally, we discuss the potential bias in neuroimaging findings that is generated by some behavioural and brain structure variables. Our method can also be applied to other kind of networks such as protein interaction networks, gene networks or social networks. |
eu_rights_str_mv | openAccess |
format | article |
id | COLIBRI_4601796047b0ad7bda40a5d7560a51b3 |
identifier_str_mv | Fraiman, D., Fraiman, R. "An ANOVA approach for statistical comparisons of brain networks". Scientific Reports, 2018, 8: 4746. doi: 10.1038/s41598-018-23152-5 2045-2322 10.1038/s41598-018-23152-5 |
instacron_str | Universidad de la República |
institution | Universidad de la República |
instname_str | Universidad de la República |
language | eng |
language_invalid_str_mv | en |
network_acronym_str | COLIBRI |
network_name_str | COLIBRI |
oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/21998 |
publishDate | 2018 |
reponame_str | COLIBRI |
repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
repository.name.fl_str_mv | COLIBRI - Universidad de la República |
repository_id_str | 4771 |
rights_invalid_str_mv | Licencia Creative Commons Atribución (CC –BY 4.0) |
spelling | Fraiman, Ricardo. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Matemática.2019-10-02T22:08:21Z2019-10-02T22:08:21Z201820190930Fraiman, D., Fraiman, R. "An ANOVA approach for statistical comparisons of brain networks". Scientific Reports, 2018, 8: 4746. doi: 10.1038/s41598-018-23152-52045-2322https://hdl.handle.net/20.500.12008/2199810.1038/s41598-018-23152-5The study of brain networks has developed extensively over the last couple of decades. By contrast, techniques for the statistical analysis of these networks are less developed. In this paper, we focus on the statistical comparison of brain networks in a nonparametric framework and discuss the associated detection and identification problems. We tested network differences between groups with an analysis of variance (ANOVA) test we developed specifically for networks. We also propose and analyse the behaviour of a new statistical procedure designed to identify different subnetworks. As an example, we show the application of this tool in resting-state fMRI data obtained from the Human Connectome Project. We identify, among other variables, that the amount of sleep the days before the scan is a relevant variable that must be controlled. Finally, we discuss the potential bias in neuroimaging findings that is generated by some behavioural and brain structure variables. Our method can also be applied to other kind of networks such as protein interaction networks, gene networks or social networks.Made available in DSpace on 2019-10-02T22:08:21Z (GMT). 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- Universidad de la Repúblicafalse |
spellingShingle | An ANOVA approach for statistical comparisons of brain networks Fraiman, D Analysis of variance Brain Neuroimaging Social network |
status_str | publishedVersion |
title | An ANOVA approach for statistical comparisons of brain networks |
title_full | An ANOVA approach for statistical comparisons of brain networks |
title_fullStr | An ANOVA approach for statistical comparisons of brain networks |
title_full_unstemmed | An ANOVA approach for statistical comparisons of brain networks |
title_short | An ANOVA approach for statistical comparisons of brain networks |
title_sort | An ANOVA approach for statistical comparisons of brain networks |
topic | Analysis of variance Brain Neuroimaging Social network |
url | https://hdl.handle.net/20.500.12008/21998 |