An ANOVA approach for statistical comparisons of brain networks

Fraiman, D - Fraiman, Ricardo

Resumen:

The study of brain networks has developed extensively over the last couple of decades. By contrast, techniques for the statistical analysis of these networks are less developed. In this paper, we focus on the statistical comparison of brain networks in a nonparametric framework and discuss the associated detection and identification problems. We tested network differences between groups with an analysis of variance (ANOVA) test we developed specifically for networks. We also propose and analyse the behaviour of a new statistical procedure designed to identify different subnetworks. As an example, we show the application of this tool in resting-state fMRI data obtained from the Human Connectome Project. We identify, among other variables, that the amount of sleep the days before the scan is a relevant variable that must be controlled. Finally, we discuss the potential bias in neuroimaging findings that is generated by some behavioural and brain structure variables. Our method can also be applied to other kind of networks such as protein interaction networks, gene networks or social networks.


Detalles Bibliográficos
2018
Analysis of variance
Brain
Neuroimaging
Social network
Inglés
Universidad de la República
COLIBRI
https://hdl.handle.net/20.500.12008/21998
Acceso abierto
Licencia Creative Commons Atribución (CC –BY 4.0)
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author Fraiman, D
author2 Fraiman, Ricardo
author2_role author
author_facet Fraiman, D
Fraiman, Ricardo
author_role author
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dc.contributor.filiacion.es.fl_str_mv Fraiman, Ricardo. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Matemática.
dc.creator.none.fl_str_mv Fraiman, D
Fraiman, Ricardo
dc.date.accessioned.none.fl_str_mv 2019-10-02T22:08:21Z
dc.date.available.none.fl_str_mv 2019-10-02T22:08:21Z
dc.date.issued.es.fl_str_mv 2018
dc.date.submitted.es.fl_str_mv 20190930
dc.description.abstract.none.fl_txt_mv The study of brain networks has developed extensively over the last couple of decades. By contrast, techniques for the statistical analysis of these networks are less developed. In this paper, we focus on the statistical comparison of brain networks in a nonparametric framework and discuss the associated detection and identification problems. We tested network differences between groups with an analysis of variance (ANOVA) test we developed specifically for networks. We also propose and analyse the behaviour of a new statistical procedure designed to identify different subnetworks. As an example, we show the application of this tool in resting-state fMRI data obtained from the Human Connectome Project. We identify, among other variables, that the amount of sleep the days before the scan is a relevant variable that must be controlled. Finally, we discuss the potential bias in neuroimaging findings that is generated by some behavioural and brain structure variables. Our method can also be applied to other kind of networks such as protein interaction networks, gene networks or social networks.
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dc.identifier.citation.es.fl_str_mv Fraiman, D., Fraiman, R. "An ANOVA approach for statistical comparisons of brain networks". Scientific Reports, 2018, 8: 4746. doi: 10.1038/s41598-018-23152-5
dc.identifier.doi.es.fl_str_mv 10.1038/s41598-018-23152-5
dc.identifier.issn.es.fl_str_mv 2045-2322
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12008/21998
dc.language.iso.none.fl_str_mv en
eng
dc.publisher.es.fl_str_mv Nature Publishing Group
dc.relation.ispartof.es.fl_str_mv Scientific Reports, 2018, 8, art. no. 4746
dc.rights.license.none.fl_str_mv Licencia Creative Commons Atribución (CC –BY 4.0)
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.source.none.fl_str_mv reponame:COLIBRI
instname:Universidad de la República
instacron:Universidad de la República
dc.subject.es.fl_str_mv Analysis of variance
Brain
Neuroimaging
Social network
dc.title.none.fl_str_mv An ANOVA approach for statistical comparisons of brain networks
dc.type.es.fl_str_mv Artículo
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
description The study of brain networks has developed extensively over the last couple of decades. By contrast, techniques for the statistical analysis of these networks are less developed. In this paper, we focus on the statistical comparison of brain networks in a nonparametric framework and discuss the associated detection and identification problems. We tested network differences between groups with an analysis of variance (ANOVA) test we developed specifically for networks. We also propose and analyse the behaviour of a new statistical procedure designed to identify different subnetworks. As an example, we show the application of this tool in resting-state fMRI data obtained from the Human Connectome Project. We identify, among other variables, that the amount of sleep the days before the scan is a relevant variable that must be controlled. Finally, we discuss the potential bias in neuroimaging findings that is generated by some behavioural and brain structure variables. Our method can also be applied to other kind of networks such as protein interaction networks, gene networks or social networks.
eu_rights_str_mv openAccess
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identifier_str_mv Fraiman, D., Fraiman, R. "An ANOVA approach for statistical comparisons of brain networks". Scientific Reports, 2018, 8: 4746. doi: 10.1038/s41598-018-23152-5
2045-2322
10.1038/s41598-018-23152-5
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publishDate 2018
reponame_str COLIBRI
repository.mail.fl_str_mv mabel.seroubian@seciu.edu.uy
repository.name.fl_str_mv COLIBRI - Universidad de la República
repository_id_str 4771
rights_invalid_str_mv Licencia Creative Commons Atribución (CC –BY 4.0)
spelling Fraiman, Ricardo. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Matemática.2019-10-02T22:08:21Z2019-10-02T22:08:21Z201820190930Fraiman, D., Fraiman, R. "An ANOVA approach for statistical comparisons of brain networks". Scientific Reports, 2018, 8: 4746. doi: 10.1038/s41598-018-23152-52045-2322https://hdl.handle.net/20.500.12008/2199810.1038/s41598-018-23152-5The study of brain networks has developed extensively over the last couple of decades. By contrast, techniques for the statistical analysis of these networks are less developed. In this paper, we focus on the statistical comparison of brain networks in a nonparametric framework and discuss the associated detection and identification problems. We tested network differences between groups with an analysis of variance (ANOVA) test we developed specifically for networks. We also propose and analyse the behaviour of a new statistical procedure designed to identify different subnetworks. As an example, we show the application of this tool in resting-state fMRI data obtained from the Human Connectome Project. We identify, among other variables, that the amount of sleep the days before the scan is a relevant variable that must be controlled. Finally, we discuss the potential bias in neuroimaging findings that is generated by some behavioural and brain structure variables. Our method can also be applied to other kind of networks such as protein interaction networks, gene networks or social networks.Made available in DSpace on 2019-10-02T22:08:21Z (GMT). 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- Universidad de la Repúblicafalse
spellingShingle An ANOVA approach for statistical comparisons of brain networks
Fraiman, D
Analysis of variance
Brain
Neuroimaging
Social network
status_str publishedVersion
title An ANOVA approach for statistical comparisons of brain networks
title_full An ANOVA approach for statistical comparisons of brain networks
title_fullStr An ANOVA approach for statistical comparisons of brain networks
title_full_unstemmed An ANOVA approach for statistical comparisons of brain networks
title_short An ANOVA approach for statistical comparisons of brain networks
title_sort An ANOVA approach for statistical comparisons of brain networks
topic Analysis of variance
Brain
Neuroimaging
Social network
url https://hdl.handle.net/20.500.12008/21998