New insights into phenotype and genotype relationships in Neospora caninum
Resumen:
The successful isolation of four new Neospora caninum strains from different regions and with different backgrounds (obtained from an abortion storm or congenitally infected and asymptomatic calves) allowed us previously to characterize natural isolates, finding differences in phenotype and microsatellites. Given the variability observed, we wondered in this work whether these differences had consequences in virulence, invasion and vertical transmission using cell cultures and murine neosporosis models. In addition, we performed the genomic analysis and SNP comparative studies of the NcURU isolates. The results obtained in this work allowed us to establish that NcURU isolates are of low virulence and have unique phenotypic characteristics. Likewise, sequencing their genomes has allowed us to delve into the genetic singularities underlying these phenotypes, as well as the common mutated genes. This work opens a new perspective for diagnostic purposes and formulating possible vaccines based on attenuated strains.
| 2023 | |
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ANII: FSSA_X_2014_ 1_106026 ANII: FSSA_1_2019_1_160691 |
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Neospora caninum Virulence Chronicity Vertical transmission Abortion Animal health Single nucleotide polymorphisms |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/43099 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1807522807503912960 |
|---|---|
| author | Cabrera Castro, Andrés M. |
| author2 | Berná, Luisa López Rodríguez, Lucía Faral-Tello, Paula Arévalo, Ana Paula Crispo, Martina Francia, María E. Robello Porto, Carlos |
| author2_role | author author author author author author author |
| author_facet | Cabrera Castro, Andrés M. Berná, Luisa López Rodríguez, Lucía Faral-Tello, Paula Arévalo, Ana Paula Crispo, Martina Francia, María E. Robello Porto, Carlos |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Cabrera Castro Andrés M., Instituto Pasteur (Montevideo). Berná Luisa, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. López Rodríguez Lucía, Instituto Pasteur (Montevideo). Faral-Tello Paula, Instituto Pasteur (Montevideo). Arévalo Ana Paula, Instituto Pasteur (Montevideo). Crispo Martina, Instituto Pasteur (Montevideo). Francia María E., Universidad de la República (Uruguay). Facultad de Medicina. Robello Porto Carlos, Instituto Pasteur (Montevideo). |
| dc.creator.none.fl_str_mv | Cabrera Castro, Andrés M. Berná, Luisa López Rodríguez, Lucía Faral-Tello, Paula Arévalo, Ana Paula Crispo, Martina Francia, María E. Robello Porto, Carlos |
| dc.date.accessioned.none.fl_str_mv | 2024-03-14T15:01:14Z |
| dc.date.available.none.fl_str_mv | 2024-03-14T15:01:14Z |
| dc.date.issued.none.fl_str_mv | 2023 |
| dc.description.abstract.none.fl_txt_mv | The successful isolation of four new Neospora caninum strains from different regions and with different backgrounds (obtained from an abortion storm or congenitally infected and asymptomatic calves) allowed us previously to characterize natural isolates, finding differences in phenotype and microsatellites. Given the variability observed, we wondered in this work whether these differences had consequences in virulence, invasion and vertical transmission using cell cultures and murine neosporosis models. In addition, we performed the genomic analysis and SNP comparative studies of the NcURU isolates. The results obtained in this work allowed us to establish that NcURU isolates are of low virulence and have unique phenotypic characteristics. Likewise, sequencing their genomes has allowed us to delve into the genetic singularities underlying these phenotypes, as well as the common mutated genes. This work opens a new perspective for diagnostic purposes and formulating possible vaccines based on attenuated strains. |
| dc.description.sponsorship.none.fl_txt_mv | ANII: FSSA_X_2014_ 1_106026 ANII: FSSA_1_2019_1_160691 |
| dc.format.extent.es.fl_str_mv | 9 h. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Cabrera Castro, A, Berná, L, López Rodríguez, L [y otros autores]. "New insights into phenotype and genotype relationships in Neospora caninum". Frontiers in Veterinary Science. [en línea] 2023, 10: 1214971. 9 h. DOI: 10.3389/fvets.2023.1214971. |
| dc.identifier.doi.none.fl_str_mv | 10.3389/fvets.2023.1214971 |
| dc.identifier.issn.none.fl_str_mv | 2297-1769 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/43099 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Frontiers |
| dc.relation.ispartof.es.fl_str_mv | Frontiers in Veterinary Science, 2023, 10: 1214971. |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Neospora caninum Virulence Chronicity Vertical transmission Abortion Animal health Single nucleotide polymorphisms |
| dc.title.none.fl_str_mv | New insights into phenotype and genotype relationships in Neospora caninum |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | The successful isolation of four new Neospora caninum strains from different regions and with different backgrounds (obtained from an abortion storm or congenitally infected and asymptomatic calves) allowed us previously to characterize natural isolates, finding differences in phenotype and microsatellites. Given the variability observed, we wondered in this work whether these differences had consequences in virulence, invasion and vertical transmission using cell cultures and murine neosporosis models. In addition, we performed the genomic analysis and SNP comparative studies of the NcURU isolates. The results obtained in this work allowed us to establish that NcURU isolates are of low virulence and have unique phenotypic characteristics. Likewise, sequencing their genomes has allowed us to delve into the genetic singularities underlying these phenotypes, as well as the common mutated genes. This work opens a new perspective for diagnostic purposes and formulating possible vaccines based on attenuated strains. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_443c77cfb9a1b913f064211b0b421eab |
| identifier_str_mv | Cabrera Castro, A, Berná, L, López Rodríguez, L [y otros autores]. "New insights into phenotype and genotype relationships in Neospora caninum". Frontiers in Veterinary Science. [en línea] 2023, 10: 1214971. 9 h. DOI: 10.3389/fvets.2023.1214971. 2297-1769 10.3389/fvets.2023.1214971 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/43099 |
| publishDate | 2023 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Cabrera Castro Andrés M., Instituto Pasteur (Montevideo).Berná Luisa, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.López Rodríguez Lucía, Instituto Pasteur (Montevideo).Faral-Tello Paula, Instituto Pasteur (Montevideo).Arévalo Ana Paula, Instituto Pasteur (Montevideo).Crispo Martina, Instituto Pasteur (Montevideo).Francia María E., Universidad de la República (Uruguay). Facultad de Medicina.Robello Porto Carlos, Instituto Pasteur (Montevideo).2024-03-14T15:01:14Z2024-03-14T15:01:14Z2023Cabrera Castro, A, Berná, L, López Rodríguez, L [y otros autores]. "New insights into phenotype and genotype relationships in Neospora caninum". Frontiers in Veterinary Science. [en línea] 2023, 10: 1214971. 9 h. DOI: 10.3389/fvets.2023.1214971.2297-1769https://hdl.handle.net/20.500.12008/4309910.3389/fvets.2023.1214971The successful isolation of four new Neospora caninum strains from different regions and with different backgrounds (obtained from an abortion storm or congenitally infected and asymptomatic calves) allowed us previously to characterize natural isolates, finding differences in phenotype and microsatellites. Given the variability observed, we wondered in this work whether these differences had consequences in virulence, invasion and vertical transmission using cell cultures and murine neosporosis models. In addition, we performed the genomic analysis and SNP comparative studies of the NcURU isolates. The results obtained in this work allowed us to establish that NcURU isolates are of low virulence and have unique phenotypic characteristics. Likewise, sequencing their genomes has allowed us to delve into the genetic singularities underlying these phenotypes, as well as the common mutated genes. This work opens a new perspective for diagnostic purposes and formulating possible vaccines based on attenuated strains.Submitted by Pintos Natalia (nataliapintosmvd@gmail.com) on 2024-03-12T14:41:02Z No. of bitstreams: 2 license_rdf: 24251 bytes, checksum: 71ed42ef0a0b648670f707320be37b90 (MD5) 10.3389fvets.2023.1214971.pdf: 1724232 bytes, checksum: a881b878fa1771782d20884e4437546c (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2024-03-14T14:59:06Z (GMT) No. of bitstreams: 2 license_rdf: 24251 bytes, checksum: 71ed42ef0a0b648670f707320be37b90 (MD5) 10.3389fvets.2023.1214971.pdf: 1724232 bytes, checksum: a881b878fa1771782d20884e4437546c (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2024-03-14T15:01:14Z (GMT). No. of bitstreams: 2 license_rdf: 24251 bytes, checksum: 71ed42ef0a0b648670f707320be37b90 (MD5) 10.3389fvets.2023.1214971.pdf: 1724232 bytes, checksum: a881b878fa1771782d20884e4437546c (MD5) Previous issue date: 2023ANII: FSSA_X_2014_ 1_106026ANII: FSSA_1_2019_1_1606919 h.application/pdfenengFrontiersFrontiers in Veterinary Science, 2023, 10: 1214971.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Neospora caninumVirulenceChronicityVertical transmissionAbortionAnimal healthSingle nucleotide polymorphismsNew insights into phenotype and genotype relationships in Neospora caninumArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaCabrera Castro, Andrés M.Berná, LuisaLópez Rodríguez, LucíaFaral-Tello, PaulaArévalo, Ana PaulaCrispo, MartinaFrancia, María E.Robello Porto, CarlosLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/43099/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-844http://localhost:8080/xmlui/bitstream/20.500.12008/43099/2/license_urla0ebbeafb9d2ec7cbb19d7137ebc392cMD52license_textlicense_texttext/html; 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- Universidad de la Repúblicafalse |
| spellingShingle | New insights into phenotype and genotype relationships in Neospora caninum Cabrera Castro, Andrés M. Neospora caninum Virulence Chronicity Vertical transmission Abortion Animal health Single nucleotide polymorphisms |
| status_str | publishedVersion |
| title | New insights into phenotype and genotype relationships in Neospora caninum |
| title_full | New insights into phenotype and genotype relationships in Neospora caninum |
| title_fullStr | New insights into phenotype and genotype relationships in Neospora caninum |
| title_full_unstemmed | New insights into phenotype and genotype relationships in Neospora caninum |
| title_short | New insights into phenotype and genotype relationships in Neospora caninum |
| title_sort | New insights into phenotype and genotype relationships in Neospora caninum |
| topic | Neospora caninum Virulence Chronicity Vertical transmission Abortion Animal health Single nucleotide polymorphisms |
| url | https://hdl.handle.net/20.500.12008/43099 |
