This study compared the osteogenic potential of two types of bovine bone blocks. Blocks were obtained by either sintered or a nonsintered process. Calvaria were surgically exposed in 20 rabbits. In each animal, six 0.5-mm-diameter cortical microperforations were drilled with a carbide bur before grafting to promote graft irrigation. The sintered (group 1) and nonsintered (group 2) bovine bone blocks (6 mm diameter, 5 mm high) were bilaterally screwed onto calvarial bone. Blocks were previously prepared from a larger block using a trephine bur. Rabbits were sacrificed after 6 and 8 weeks for the histological and histomorphometric analyses. Samples were processed using the historesin technique. The quantitative and qualitative analyses of the newly formed bone were undertaken using light microscopy. Both groups showed modest new bone formation and remodeling. At the 8-week follow-up, the sintered group displayed significantly lower bone resorption (average of 10% in group 1 and 25% in group 2) and neo-formation (12.86 ± 1.52%) compared to the nonsintered group (16.10 ± 1.29%) at both follow-ups (p < 0.05). One limitation of the present animal model is that the study demonstrates that variations in the physico-chemical properties of the bone substitute material clearly influence the in vivo behavior.