Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota
Resumen:
Campylobacter fetus is a venereal pathogen of cattle and sheep, and an opportunistic human pathogen. It is often assumed that C. fetus infection occurs in humans as a zoonosis through food chain transmission. Here we show that mammalian C. fetus consists of distinct evolutionary lineages, primarily associated with either human or bovine hosts. We use whole-genome phylogenetics on 182 strains from 17 countries to provide evidence that C. fetus may have originated in humans around 10,500 years ago and may have "jumped" into cattle during the livestock domestication period. We detect C. fetus genomes in 8% of healthy human fecal metagenomes, where the human-associated lineages are the dominant type (78%). Thus, our work suggests that C. fetus is an unappreciated human intestinal pathobiont likely spread by human to human transmission. This genome-based evolutionary framework will facilitate C. fetus epidemiology research and the development of improved molecular diagnostics and prevention schemes for this neglected pathogen
| 2017 | |
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Bacterium Cattle Digestive system Domestication Food chain Genome Pathogen Phylogenetics |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/22038 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC –BY 4.0) |
| _version_ | 1807522779930558464 |
|---|---|
| author | Iraola, Gregorio |
| author2 | Forster, S. C. Kumar, N. Lehours, P. Bekal, S. García-Peña, F. J. Paolicchi, F. Morsella, C. Hotzel, H. Hsueh, P.-R. Vidal, A. Lévesque, S. Yamazaki, W. Balzan, C. Vargas, A. Piccirillo, A. Chaban, B. Hill, J. E. Betancor, Laura Collado, L. Truyers, I. Midwinter, A. C. Dagi, H. T. Mégraud, F. Calleros Basilio, Lucía Pérez Crossa, Ruben Gustavo Naya Monteverde, Hugo Mario Lawley, T. D. |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Iraola, Gregorio Forster, S. C. Kumar, N. Lehours, P. Bekal, S. García-Peña, F. J. Paolicchi, F. Morsella, C. Hotzel, H. Hsueh, P.-R. Vidal, A. Lévesque, S. Yamazaki, W. Balzan, C. Vargas, A. Piccirillo, A. Chaban, B. Hill, J. E. Betancor, Laura Collado, L. Truyers, I. Midwinter, A. C. Dagi, H. T. Mégraud, F. Calleros Basilio, Lucía Pérez Crossa, Ruben Gustavo Naya Monteverde, Hugo Mario Lawley, T. D. |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.es.fl_str_mv | Iraola, Gregorio. Instituto Pasteur (Montevideo) Calleros Basilio, Lucía. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva Pérez Crossa, Ruben Gustavo. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva Naya Monteverde, Hugo Mario. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva. |
| dc.creator.none.fl_str_mv | Iraola, Gregorio Forster, S. C. Kumar, N. Lehours, P. Bekal, S. García-Peña, F. J. Paolicchi, F. Morsella, C. Hotzel, H. Hsueh, P.-R. Vidal, A. Lévesque, S. Yamazaki, W. Balzan, C. Vargas, A. Piccirillo, A. Chaban, B. Hill, J. E. Betancor, Laura Collado, L. Truyers, I. Midwinter, A. C. Dagi, H. T. Mégraud, F. Calleros Basilio, Lucía Pérez Crossa, Ruben Gustavo Naya Monteverde, Hugo Mario Lawley, T. D. |
| dc.date.accessioned.none.fl_str_mv | 2019-10-02T22:08:35Z |
| dc.date.available.none.fl_str_mv | 2019-10-02T22:08:35Z |
| dc.date.issued.es.fl_str_mv | 2017 |
| dc.date.submitted.es.fl_str_mv | 20190930 |
| dc.description.abstract.none.fl_txt_mv | Campylobacter fetus is a venereal pathogen of cattle and sheep, and an opportunistic human pathogen. It is often assumed that C. fetus infection occurs in humans as a zoonosis through food chain transmission. Here we show that mammalian C. fetus consists of distinct evolutionary lineages, primarily associated with either human or bovine hosts. We use whole-genome phylogenetics on 182 strains from 17 countries to provide evidence that C. fetus may have originated in humans around 10,500 years ago and may have "jumped" into cattle during the livestock domestication period. We detect C. fetus genomes in 8% of healthy human fecal metagenomes, where the human-associated lineages are the dominant type (78%). Thus, our work suggests that C. fetus is an unappreciated human intestinal pathobiont likely spread by human to human transmission. This genome-based evolutionary framework will facilitate C. fetus epidemiology research and the development of improved molecular diagnostics and prevention schemes for this neglected pathogen |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Iraola, G., et al. Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota. Nature Communications 2017, 8: 1367, doi: 10.1038/s41467-017-01449-9 |
| dc.identifier.doi.es.fl_str_mv | 10.1038/s41467-017-01449-9 |
| dc.identifier.issn.es.fl_str_mv | 2041-1723 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/22038 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Nature Publishing Group |
| dc.relation.ispartof.es.fl_str_mv | Nature Communications, 2017, 8, art. no. 1367 |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC –BY 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Bacterium Cattle Digestive system Domestication Food chain Genome Pathogen Phylogenetics |
| dc.title.none.fl_str_mv | Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Campylobacter fetus is a venereal pathogen of cattle and sheep, and an opportunistic human pathogen. It is often assumed that C. fetus infection occurs in humans as a zoonosis through food chain transmission. Here we show that mammalian C. fetus consists of distinct evolutionary lineages, primarily associated with either human or bovine hosts. We use whole-genome phylogenetics on 182 strains from 17 countries to provide evidence that C. fetus may have originated in humans around 10,500 years ago and may have "jumped" into cattle during the livestock domestication period. We detect C. fetus genomes in 8% of healthy human fecal metagenomes, where the human-associated lineages are the dominant type (78%). Thus, our work suggests that C. fetus is an unappreciated human intestinal pathobiont likely spread by human to human transmission. This genome-based evolutionary framework will facilitate C. fetus epidemiology research and the development of improved molecular diagnostics and prevention schemes for this neglected pathogen |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_265ef88becb935c3f2b22cd23675e597 |
| identifier_str_mv | Iraola, G., et al. Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota. Nature Communications 2017, 8: 1367, doi: 10.1038/s41467-017-01449-9 2041-1723 10.1038/s41467-017-01449-9 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/22038 |
| publishDate | 2017 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC –BY 4.0) |
| spelling | Iraola, Gregorio. Instituto Pasteur (Montevideo)Calleros Basilio, Lucía. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Sección Genética EvolutivaPérez Crossa, Ruben Gustavo. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Sección Genética EvolutivaNaya Monteverde, Hugo Mario. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva.2019-10-02T22:08:35Z2019-10-02T22:08:35Z201720190930Iraola, G., et al. Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota. Nature Communications 2017, 8: 1367, doi: 10.1038/s41467-017-01449-92041-1723https://hdl.handle.net/20.500.12008/2203810.1038/s41467-017-01449-9Campylobacter fetus is a venereal pathogen of cattle and sheep, and an opportunistic human pathogen. It is often assumed that C. fetus infection occurs in humans as a zoonosis through food chain transmission. Here we show that mammalian C. fetus consists of distinct evolutionary lineages, primarily associated with either human or bovine hosts. We use whole-genome phylogenetics on 182 strains from 17 countries to provide evidence that C. fetus may have originated in humans around 10,500 years ago and may have "jumped" into cattle during the livestock domestication period. We detect C. fetus genomes in 8% of healthy human fecal metagenomes, where the human-associated lineages are the dominant type (78%). Thus, our work suggests that C. fetus is an unappreciated human intestinal pathobiont likely spread by human to human transmission. This genome-based evolutionary framework will facilitate C. fetus epidemiology research and the development of improved molecular diagnostics and prevention schemes for this neglected pathogenMade available in DSpace on 2019-10-02T22:08:35Z (GMT). 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Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC –BY 4.0)BacteriumCattleDigestive systemDomesticationFood chainGenomePathogenPhylogeneticsDistinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiotaArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaIraola, GregorioForster, S. C.Kumar, N.Lehours, P.Bekal, S.García-Peña, F. J.Paolicchi, F.Morsella, C.Hotzel, H.Hsueh, P.-R.Vidal, A.Lévesque, S.Yamazaki, W.Balzan, C.Vargas, A.Piccirillo, A.Chaban, B.Hill, J. E.Betancor, LauraCollado, L.Truyers, I.Midwinter, A. C.Dagi, H. T.Mégraud, F.Calleros Basilio, LucíaPérez Crossa, Ruben GustavoNaya Monteverde, Hugo MarioLawley, T. 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- Universidad de la Repúblicafalse |
| spellingShingle | Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota Iraola, Gregorio Bacterium Cattle Digestive system Domestication Food chain Genome Pathogen Phylogenetics |
| status_str | publishedVersion |
| title | Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota |
| title_full | Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota |
| title_fullStr | Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota |
| title_full_unstemmed | Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota |
| title_short | Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota |
| title_sort | Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota |
| topic | Bacterium Cattle Digestive system Domestication Food chain Genome Pathogen Phylogenetics |
| url | https://hdl.handle.net/20.500.12008/22038 |
