RNA-seq data exploration after trypanosome RNA-binding protein UBP1 expression is altered by CRISPR-Cas9 gene editing and overexpression
Resumen:
Previous studies have shown that overexpression of the Trypanosoma cruzi U-rich RNA-binding protein 1 (TcUBP1) in insect-dwelling epimastigotes results in a gene expression pattern resembling that of the infective form of the pathogen. Here, we used CRISPR-Cas9-induced edition of TcUBP1 and full-length protein overexpression in epimastigote cells to monitor transcriptomic changes during the epimastigote-to-metacyclic trypomastigote stage transition of T. cruzi. This dataset includes the bioinformatics analysis of three different RNA-seq samples, each with three biological replicates, showing differential mRNA abundances. The current transcriptome report has the potential to shed light on the quantitative variances in the expression of significant
| 2024 | |
|
RNA-binding protein Transcriptomics Trypanosoma cruzi Differential gene expression Parasite differentiation |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/50280 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1872864699231502336 |
|---|---|
| author | Sabalette, Karina B |
| author2 | Campo, Vanina A Sotelo-Silveira, José Roberto Smircich, Pablo De Gaudenzi, Javier G. |
| author2_role | author author author author |
| author_facet | Sabalette, Karina B Campo, Vanina A Sotelo-Silveira, José Roberto Smircich, Pablo De Gaudenzi, Javier G. |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Sabalette Karina B Campo Vanina A Sotelo-Silveira José Roberto, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Smircich Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. De Gaudenzi Javier G. |
| dc.creator.none.fl_str_mv | Sabalette, Karina B Campo, Vanina A Sotelo-Silveira, José Roberto Smircich, Pablo De Gaudenzi, Javier G. |
| dc.date.accessioned.none.fl_str_mv | 2025-06-11T17:05:56Z |
| dc.date.available.none.fl_str_mv | 2025-06-11T17:05:56Z |
| dc.date.issued.none.fl_str_mv | 2024 |
| dc.description.abstract.none.fl_txt_mv | Previous studies have shown that overexpression of the Trypanosoma cruzi U-rich RNA-binding protein 1 (TcUBP1) in insect-dwelling epimastigotes results in a gene expression pattern resembling that of the infective form of the pathogen. Here, we used CRISPR-Cas9-induced edition of TcUBP1 and full-length protein overexpression in epimastigote cells to monitor transcriptomic changes during the epimastigote-to-metacyclic trypomastigote stage transition of T. cruzi. This dataset includes the bioinformatics analysis of three different RNA-seq samples, each with three biological replicates, showing differential mRNA abundances. The current transcriptome report has the potential to shed light on the quantitative variances in the expression of significant |
| dc.description.es.fl_txt_mv | Material suplementario en: doi:10.1016/j.dib.2024.110156 |
| dc.format.extent.es.fl_str_mv | 5 h |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Sabalette, K, Campo, V, Sotelo Silveira, J [y otros autores]. "RNA-seq data exploration after trypanosome RNA-binding protein UBP1 expression is altered by CRISPR-Cas9 gene editing and overexpression". Data in Brief. [en línea] 2024, 53: 110156. 5 h. DOI: 10.1016/j.dib.2024.110156 |
| dc.identifier.doi.none.fl_str_mv | 10.1016/j.dib.2024.110156 |
| dc.identifier.issn.none.fl_str_mv | 2352-3409 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/50280 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | Data in Brief, 2024, 53: 110156. |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | RNA-binding protein Transcriptomics Trypanosoma cruzi Differential gene expression Parasite differentiation |
| dc.title.none.fl_str_mv | RNA-seq data exploration after trypanosome RNA-binding protein UBP1 expression is altered by CRISPR-Cas9 gene editing and overexpression |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Material suplementario en: doi:10.1016/j.dib.2024.110156 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_215c30a7aaf873495fa0e97915c9da7f |
| identifier_str_mv | Sabalette, K, Campo, V, Sotelo Silveira, J [y otros autores]. "RNA-seq data exploration after trypanosome RNA-binding protein UBP1 expression is altered by CRISPR-Cas9 gene editing and overexpression". Data in Brief. [en línea] 2024, 53: 110156. 5 h. DOI: 10.1016/j.dib.2024.110156 2352-3409 10.1016/j.dib.2024.110156 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/50280 |
| publishDate | 2024 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | karina.camps@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Sabalette Karina BCampo Vanina ASotelo-Silveira José Roberto, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Smircich Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.De Gaudenzi Javier G.2025-06-11T17:05:56Z2025-06-11T17:05:56Z2024Sabalette, K, Campo, V, Sotelo Silveira, J [y otros autores]. "RNA-seq data exploration after trypanosome RNA-binding protein UBP1 expression is altered by CRISPR-Cas9 gene editing and overexpression". Data in Brief. [en línea] 2024, 53: 110156. 5 h. DOI: 10.1016/j.dib.2024.1101562352-3409https://hdl.handle.net/20.500.12008/5028010.1016/j.dib.2024.110156Material suplementario en: doi:10.1016/j.dib.2024.110156Previous studies have shown that overexpression of the Trypanosoma cruzi U-rich RNA-binding protein 1 (TcUBP1) in insect-dwelling epimastigotes results in a gene expression pattern resembling that of the infective form of the pathogen. Here, we used CRISPR-Cas9-induced edition of TcUBP1 and full-length protein overexpression in epimastigote cells to monitor transcriptomic changes during the epimastigote-to-metacyclic trypomastigote stage transition of T. cruzi. This dataset includes the bioinformatics analysis of three different RNA-seq samples, each with three biological replicates, showing differential mRNA abundances. The current transcriptome report has the potential to shed light on the quantitative variances in the expression of significantSubmitted by Pintos Natalia (nataliapintosmvd@gmail.com) on 2025-06-05T10:22:25Z No. of bitstreams: 2 license_rdf: 24942 bytes, checksum: 58cb336ce230a47d2f88ad02838a665f (MD5) 10.1016-j.dib.2024.110156.pdf: 335876 bytes, checksum: c1058b19e5d8d98cd4109d696bc394fe (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2025-06-09T18:45:17Z (GMT) No. of bitstreams: 2 license_rdf: 24942 bytes, checksum: 58cb336ce230a47d2f88ad02838a665f (MD5) 10.1016-j.dib.2024.110156.pdf: 335876 bytes, checksum: c1058b19e5d8d98cd4109d696bc394fe (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2025-06-11T17:05:56Z (GMT). No. of bitstreams: 2 license_rdf: 24942 bytes, checksum: 58cb336ce230a47d2f88ad02838a665f (MD5) 10.1016-j.dib.2024.110156.pdf: 335876 bytes, checksum: c1058b19e5d8d98cd4109d696bc394fe (MD5) Previous issue date: 20245 happlication/pdfenengElsevierData in Brief, 2024, 53: 110156.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)RNA-binding proteinTranscriptomicsTrypanosoma cruziDifferential gene expressionParasite differentiationRNA-seq data exploration after trypanosome RNA-binding protein UBP1 expression is altered by CRISPR-Cas9 gene editing and overexpressionArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaSabalette, Karina BCampo, Vanina ASotelo-Silveira, José RobertoSmircich, PabloDe Gaudenzi, Javier G.LICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/50280/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-844http://localhost:8080/xmlui/bitstream/20.500.12008/50280/2/license_urla0ebbeafb9d2ec7cbb19d7137ebc392cMD52license_textlicense_texttext/html; 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públicahttps://udelar.edu.uy/https://www.colibri.udelar.edu.uy/oai/requestkarina.camps@seciu.edu.uyUruguayopendoar:47712025-09-30T18:01:26COLIBRI - Universidad de la Repúblicafalse |
| spellingShingle | RNA-seq data exploration after trypanosome RNA-binding protein UBP1 expression is altered by CRISPR-Cas9 gene editing and overexpression Sabalette, Karina B RNA-binding protein Transcriptomics Trypanosoma cruzi Differential gene expression Parasite differentiation |
| status_str | publishedVersion |
| title | RNA-seq data exploration after trypanosome RNA-binding protein UBP1 expression is altered by CRISPR-Cas9 gene editing and overexpression |
| title_full | RNA-seq data exploration after trypanosome RNA-binding protein UBP1 expression is altered by CRISPR-Cas9 gene editing and overexpression |
| title_fullStr | RNA-seq data exploration after trypanosome RNA-binding protein UBP1 expression is altered by CRISPR-Cas9 gene editing and overexpression |
| title_full_unstemmed | RNA-seq data exploration after trypanosome RNA-binding protein UBP1 expression is altered by CRISPR-Cas9 gene editing and overexpression |
| title_short | RNA-seq data exploration after trypanosome RNA-binding protein UBP1 expression is altered by CRISPR-Cas9 gene editing and overexpression |
| title_sort | RNA-seq data exploration after trypanosome RNA-binding protein UBP1 expression is altered by CRISPR-Cas9 gene editing and overexpression |
| topic | RNA-binding protein Transcriptomics Trypanosoma cruzi Differential gene expression Parasite differentiation |
| url | https://hdl.handle.net/20.500.12008/50280 |
