Trends in volumetric-energy efficiency of implantable neurostimulators : A review from a circuits and systems perspective.

Martínez Bentancor, Santiago - Veirano Núñez, Francisco - Constandinou, Timothy G. - Silveira, Fernando

Resumen:

This paper presents a comprehensive review of state-of-the-art, commercially available neurostimulators. We analyse key design parameters and performance metrics of 45 implantable medical devices across six neural target categories: deep brain, vagus nerve, spinal cord, phrenic nerve, sacral nerve and hypoglossal nerve. We then benchmark these alongside modern cardiac pacemaker devices that represent a more established market. This work studies trends in device size, electrode number, battery technology (i.e., primary and secondary use and chemistry), power consumption and longevity. This information is analysed to show the course of design decisions adopted by industry and identifying opportunity for further innovation. We identify fundamental limits in power consumption, longevity and size as well as the interdependencies and trade-offs. We propose a figure of merit to quantify volumetric efficiency within specific therapeutic targets, battery technologies/capacities, charging capabilities and electrode count. Finally, we compare commercially available implantable medical devices with recently developed systems in the research community. We envisage this analysis to aid circuit and system designers in system optimisation and identifying innovation opportunities, particularly those related to low power circuit design techniques.


Detalles Bibliográficos
2023
CSIC - Universidad de la República.
Batteries
Pain
Diseases
Medical treatment
Sleep apnea
Medical devices
Sensors
Neurostimulators
Neuromodulation
Implantable medical devices
Neural interface
Energy efficiency
Miniaturisation
Batt
Inglés
Universidad de la República
COLIBRI
https://ieeexplore.ieee.org/document/9984934
https://hdl.handle.net/20.500.12008/37218
Acceso abierto
Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)
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author Martínez Bentancor, Santiago
author2 Veirano Núñez, Francisco
Constandinou, Timothy G.
Silveira, Fernando
author2_role author
author
author
author_facet Martínez Bentancor, Santiago
Veirano Núñez, Francisco
Constandinou, Timothy G.
Silveira, Fernando
author_role author
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dc.contributor.filiacion.none.fl_str_mv Martínez Bentancor Santiago, Universidad de la República (Uruguay). Facultad de Ingeniería.
Veirano Núñez Francisco, Universidad de la República (Uruguay). Facultad de Ingeniería.
Constandinou Timothy G., Imperial College London, UK
Silveira Fernando, Universidad de la República (Uruguay). Facultad de Ingeniería.
dc.creator.none.fl_str_mv Martínez Bentancor, Santiago
Veirano Núñez, Francisco
Constandinou, Timothy G.
Silveira, Fernando
dc.date.accessioned.none.fl_str_mv 2023-05-24T13:39:40Z
dc.date.available.none.fl_str_mv 2023-05-24T13:39:40Z
dc.date.issued.none.fl_str_mv 2023
dc.description.abstract.none.fl_txt_mv This paper presents a comprehensive review of state-of-the-art, commercially available neurostimulators. We analyse key design parameters and performance metrics of 45 implantable medical devices across six neural target categories: deep brain, vagus nerve, spinal cord, phrenic nerve, sacral nerve and hypoglossal nerve. We then benchmark these alongside modern cardiac pacemaker devices that represent a more established market. This work studies trends in device size, electrode number, battery technology (i.e., primary and secondary use and chemistry), power consumption and longevity. This information is analysed to show the course of design decisions adopted by industry and identifying opportunity for further innovation. We identify fundamental limits in power consumption, longevity and size as well as the interdependencies and trade-offs. We propose a figure of merit to quantify volumetric efficiency within specific therapeutic targets, battery technologies/capacities, charging capabilities and electrode count. Finally, we compare commercially available implantable medical devices with recently developed systems in the research community. We envisage this analysis to aid circuit and system designers in system optimisation and identifying innovation opportunities, particularly those related to low power circuit design techniques.
dc.description.es.fl_txt_mv Publicado en IEEE Transactions on Biomedical Circuits and Systems, vol. 17, no 1, feb 2023, pp 2-20
dc.description.sponsorship.none.fl_txt_mv CSIC - Universidad de la República.
dc.format.extent.es.fl_str_mv 19 p.
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dc.identifier.citation.es.fl_str_mv Martínez Bentancor, S., Veirano Núñez, F., Constandinou, T. y otros. "Trends in volumetric-energy efficiency of implantable neurostimulators : A review from a circuits and systems perspective" [Preprint]. Publicado en: IEEE Transactions on Biomedical Circuits and Systems. 2023, vol. 17, no 1, pp 2-20. DOI: 10.1109/TBCAS.2022.3228895
dc.identifier.issn.none.fl_str_mv 1932-4545
dc.identifier.uri.none.fl_str_mv https://ieeexplore.ieee.org/document/9984934
https://hdl.handle.net/20.500.12008/37218
dc.language.iso.none.fl_str_mv en
eng
dc.rights.license.none.fl_str_mv Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.source.none.fl_str_mv reponame:COLIBRI
instname:Universidad de la República
instacron:Universidad de la República
dc.subject.es.fl_str_mv Batteries
Pain
Diseases
Medical treatment
Sleep apnea
Medical devices
Sensors
Neurostimulators
Neuromodulation
Implantable medical devices
Neural interface
Energy efficiency
Miniaturisation
Batt
dc.title.none.fl_str_mv Trends in volumetric-energy efficiency of implantable neurostimulators : A review from a circuits and systems perspective.
dc.type.es.fl_str_mv Preprint
dc.type.none.fl_str_mv info:eu-repo/semantics/preprint
dc.type.version.none.fl_str_mv info:eu-repo/semantics/submittedVersion
description Publicado en IEEE Transactions on Biomedical Circuits and Systems, vol. 17, no 1, feb 2023, pp 2-20
eu_rights_str_mv openAccess
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identifier_str_mv Martínez Bentancor, S., Veirano Núñez, F., Constandinou, T. y otros. "Trends in volumetric-energy efficiency of implantable neurostimulators : A review from a circuits and systems perspective" [Preprint]. Publicado en: IEEE Transactions on Biomedical Circuits and Systems. 2023, vol. 17, no 1, pp 2-20. DOI: 10.1109/TBCAS.2022.3228895
1932-4545
instacron_str Universidad de la República
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publishDate 2023
reponame_str COLIBRI
repository.mail.fl_str_mv mabel.seroubian@seciu.edu.uy
repository.name.fl_str_mv COLIBRI - Universidad de la República
repository_id_str 4771
rights_invalid_str_mv Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)
spelling Martínez Bentancor Santiago, Universidad de la República (Uruguay). Facultad de Ingeniería.Veirano Núñez Francisco, Universidad de la República (Uruguay). Facultad de Ingeniería.Constandinou Timothy G., Imperial College London, UKSilveira Fernando, Universidad de la República (Uruguay). Facultad de Ingeniería.2023-05-24T13:39:40Z2023-05-24T13:39:40Z2023Martínez Bentancor, S., Veirano Núñez, F., Constandinou, T. y otros. "Trends in volumetric-energy efficiency of implantable neurostimulators : A review from a circuits and systems perspective" [Preprint]. Publicado en: IEEE Transactions on Biomedical Circuits and Systems. 2023, vol. 17, no 1, pp 2-20. DOI: 10.1109/TBCAS.2022.32288951932-4545https://ieeexplore.ieee.org/document/9984934https://hdl.handle.net/20.500.12008/37218Publicado en IEEE Transactions on Biomedical Circuits and Systems, vol. 17, no 1, feb 2023, pp 2-20This paper presents a comprehensive review of state-of-the-art, commercially available neurostimulators. We analyse key design parameters and performance metrics of 45 implantable medical devices across six neural target categories: deep brain, vagus nerve, spinal cord, phrenic nerve, sacral nerve and hypoglossal nerve. We then benchmark these alongside modern cardiac pacemaker devices that represent a more established market. This work studies trends in device size, electrode number, battery technology (i.e., primary and secondary use and chemistry), power consumption and longevity. This information is analysed to show the course of design decisions adopted by industry and identifying opportunity for further innovation. We identify fundamental limits in power consumption, longevity and size as well as the interdependencies and trade-offs. We propose a figure of merit to quantify volumetric efficiency within specific therapeutic targets, battery technologies/capacities, charging capabilities and electrode count. Finally, we compare commercially available implantable medical devices with recently developed systems in the research community. We envisage this analysis to aid circuit and system designers in system optimisation and identifying innovation opportunities, particularly those related to low power circuit design techniques.Submitted by Ribeiro Jorge (jribeiro@fing.edu.uy) on 2023-05-20T00:36:01Z No. of bitstreams: 2 license_rdf: 23149 bytes, checksum: 1996b8461bc290aef6a27d78c67b6b52 (MD5) MVCS23.pdf: 12537968 bytes, checksum: 0a2d04d4c578e899492a4744bffd0dd8 (MD5)Approved for entry into archive by Berón Cecilia (cberon@fing.edu.uy) on 2023-05-23T18:37:24Z (GMT) No. of bitstreams: 2 license_rdf: 23149 bytes, checksum: 1996b8461bc290aef6a27d78c67b6b52 (MD5) MVCS23.pdf: 12537968 bytes, checksum: 0a2d04d4c578e899492a4744bffd0dd8 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2023-05-24T13:39:40Z (GMT). No. of bitstreams: 2 license_rdf: 23149 bytes, checksum: 1996b8461bc290aef6a27d78c67b6b52 (MD5) MVCS23.pdf: 12537968 bytes, checksum: 0a2d04d4c578e899492a4744bffd0dd8 (MD5) Previous issue date: 2023CSIC - Universidad de la República.19 p.application/pdfenengLas obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)BatteriesPainDiseasesMedical treatmentSleep apneaMedical devicesSensorsNeurostimulatorsNeuromodulationImplantable medical devicesNeural interfaceEnergy efficiencyMiniaturisationBattTrends in volumetric-energy efficiency of implantable neurostimulators : A review from a circuits and systems perspective.Preprintinfo:eu-repo/semantics/preprintinfo:eu-repo/semantics/submittedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaMartínez Bentancor, SantiagoVeirano Núñez, FranciscoConstandinou, Timothy G.Silveira, FernandoLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/37218/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; 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- Universidad de la Repúblicafalse
spellingShingle Trends in volumetric-energy efficiency of implantable neurostimulators : A review from a circuits and systems perspective.
Martínez Bentancor, Santiago
Batteries
Pain
Diseases
Medical treatment
Sleep apnea
Medical devices
Sensors
Neurostimulators
Neuromodulation
Implantable medical devices
Neural interface
Energy efficiency
Miniaturisation
Batt
status_str submittedVersion
title Trends in volumetric-energy efficiency of implantable neurostimulators : A review from a circuits and systems perspective.
title_full Trends in volumetric-energy efficiency of implantable neurostimulators : A review from a circuits and systems perspective.
title_fullStr Trends in volumetric-energy efficiency of implantable neurostimulators : A review from a circuits and systems perspective.
title_full_unstemmed Trends in volumetric-energy efficiency of implantable neurostimulators : A review from a circuits and systems perspective.
title_short Trends in volumetric-energy efficiency of implantable neurostimulators : A review from a circuits and systems perspective.
title_sort Trends in volumetric-energy efficiency of implantable neurostimulators : A review from a circuits and systems perspective.
topic Batteries
Pain
Diseases
Medical treatment
Sleep apnea
Medical devices
Sensors
Neurostimulators
Neuromodulation
Implantable medical devices
Neural interface
Energy efficiency
Miniaturisation
Batt
url https://ieeexplore.ieee.org/document/9984934
https://hdl.handle.net/20.500.12008/37218