Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature
Resumen:
Background: The initiation of odontogenic tumorigenesis often involves the activation of the MAP-kinase path- way, with a pivotal role played by the BRAF V600E mutation. This study aimed to investigate the frequency of BRAF V600E immunoexpresion in ameloblastomas diagnosed in four Latin American centers and correlate this finding with the histological types and subtypes of the analyzed cases.Material and Methods: A total of 86 samples of ameloblastomas were examined for immunohistochemistry using anti-BRAF V600E antibody. The histopathological features of each case were analyzed. Results: Positivity for anti-BRAF V600E antibody was detected in 65/86 cases (75.6%). BRAF V600E was positive in 38/56 cases (67.9%) of conventional ameloblastomas and in 27/30 cases (90.0%) of unicystic ameloblastomas. A statistically significant difference in BRAF V600E positivity was observed when comparing unicystic ameloblastomas to conventional ameloblastomas (p=0.03). No statistically significant difference in BRAF V600E positivity was observed when comparing histological variants, both for conventional ameloblastomas and unicystic ameloblastomas. Conclusions: This study highlights a high frequency of BRAF V600E immunoreactivity in ameloblastomas among Latin American cases. The prevalence of the BRAF V600E immunoexpresion may suggest the feasibility of utilizing BRAF-targeted therapy for ameloblastomas with this mutation.
| 2024 | |
| Comisión Sectorial de Investigación Científica - Uruguay; Agencia Nacional de Investigación e Innovación / Sistema Nacional de Investigadores - Uruguay. | |
|
Immunohistochemistry Odontogenic tumors Ameloblastoma |
|
| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/43627 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| _version_ | 1875693119698108416 |
|---|---|
| author | Silveira, Felipe Martins |
| author2 | Schuch, Lauren Frenzel Pereira-Prado, Vanesa Sicco, Estefanía Almeda-Ojeda, Oscar Molina-Frechero, Nelly Paparella, María Luisa Villarroel-Dorrego, Marina Hernández, Marcela Bologna-Molina, Ronell |
| author2_role | author author author author author author author author author |
| author_facet | Silveira, Felipe Martins Schuch, Lauren Frenzel Pereira-Prado, Vanesa Sicco, Estefanía Almeda-Ojeda, Oscar Molina-Frechero, Nelly Paparella, María Luisa Villarroel-Dorrego, Marina Hernández, Marcela Bologna-Molina, Ronell |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Silveira Felipe Martins, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Schuch Lauren Frenzel, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Sicco Estefania, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Almeda-Ojeda Oscar, Universidad Juárez del Estado de Durango (México) Molina-Frechero Nelly, Universidad Autónoma Metropolitana-Xochimilco (Mexico) Paparella María Luisa, Universidad de Buenos Aires (Argentina) Villarroel-Dorrego Marina, Universidad Central de Venezuela (Venezuela) Hernández Marcela, Universidad de Chile (Chile) Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. |
| dc.creator.none.fl_str_mv | Silveira, Felipe Martins Schuch, Lauren Frenzel Pereira-Prado, Vanesa Sicco, Estefanía Almeda-Ojeda, Oscar Molina-Frechero, Nelly Paparella, María Luisa Villarroel-Dorrego, Marina Hernández, Marcela Bologna-Molina, Ronell |
| dc.date.accessioned.none.fl_str_mv | 2024-04-24T17:41:42Z |
| dc.date.available.none.fl_str_mv | 2024-04-24T17:41:42Z |
| dc.date.issued.none.fl_str_mv | 2024 |
| dc.description.abstract.none.fl_txt_mv | Background: The initiation of odontogenic tumorigenesis often involves the activation of the MAP-kinase path- way, with a pivotal role played by the BRAF V600E mutation. This study aimed to investigate the frequency of BRAF V600E immunoexpresion in ameloblastomas diagnosed in four Latin American centers and correlate this finding with the histological types and subtypes of the analyzed cases.Material and Methods: A total of 86 samples of ameloblastomas were examined for immunohistochemistry using anti-BRAF V600E antibody. The histopathological features of each case were analyzed. Results: Positivity for anti-BRAF V600E antibody was detected in 65/86 cases (75.6%). BRAF V600E was positive in 38/56 cases (67.9%) of conventional ameloblastomas and in 27/30 cases (90.0%) of unicystic ameloblastomas. A statistically significant difference in BRAF V600E positivity was observed when comparing unicystic ameloblastomas to conventional ameloblastomas (p=0.03). No statistically significant difference in BRAF V600E positivity was observed when comparing histological variants, both for conventional ameloblastomas and unicystic ameloblastomas. Conclusions: This study highlights a high frequency of BRAF V600E immunoreactivity in ameloblastomas among Latin American cases. The prevalence of the BRAF V600E immunoexpresion may suggest the feasibility of utilizing BRAF-targeted therapy for ameloblastomas with this mutation. |
| dc.description.es.fl_txt_mv | Artículo disponible a texto completo a través de PubMed Central. Artículo head of print- article in press. |
| dc.description.sponsorship.none.fl_txt_mv | Comisión Sectorial de Investigación Científica - Uruguay; Agencia Nacional de Investigación e Innovación / Sistema Nacional de Investigadores - Uruguay. |
| dc.format.extent.es.fl_str_mv | 8 h. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Silveira, F, Frenzel Schuch, L, Pereira-Prado, [y otros autores]. "Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature". Medicina Oral Patologia Oral y Cirugia Bucal. [en línea] 2024 .8 h. |
| dc.identifier.doi.none.fl_str_mv | 0.4317/med- oral.26493 |
| dc.identifier.issn.none.fl_str_mv | 1698-6946 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/43627 |
| dc.language.iso.none.fl_str_mv | en_US eng |
| dc.publisher.es.fl_str_mv | Medicina Oral S.L |
| dc.relation.none.fl_str_mv | Medicina Oral Patologia Oral y Cirugia Bucal, 2024. |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Immunohistochemistry Odontogenic tumors Ameloblastoma |
| dc.title.none.fl_str_mv | Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Artículo disponible a texto completo a través de PubMed Central. Artículo head of print- article in press. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_12cd813fae2bc7bf85ddcb91479c2968 |
| identifier_str_mv | Silveira, F, Frenzel Schuch, L, Pereira-Prado, [y otros autores]. "Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature". Medicina Oral Patologia Oral y Cirugia Bucal. [en línea] 2024 .8 h. 1698-6946 0.4317/med- oral.26493 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en_US |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/43627 |
| publishDate | 2024 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | karina.camps@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Silveira Felipe Martins, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Schuch Lauren Frenzel, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Sicco Estefania, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Almeda-Ojeda Oscar, Universidad Juárez del Estado de Durango (México)Molina-Frechero Nelly, Universidad Autónoma Metropolitana-Xochimilco (Mexico)Paparella María Luisa, Universidad de Buenos Aires (Argentina)Villarroel-Dorrego Marina, Universidad Central de Venezuela (Venezuela)Hernández Marcela, Universidad de Chile (Chile)Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.2024-04-24T17:41:42Z2024-04-24T17:41:42Z2024Silveira, F, Frenzel Schuch, L, Pereira-Prado, [y otros autores]. "Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature". Medicina Oral Patologia Oral y Cirugia Bucal. [en línea] 2024 .8 h.1698-6946https://hdl.handle.net/20.500.12008/436270.4317/med- oral.26493Artículo disponible a texto completo a través de PubMed Central. Artículo head of print- article in press.Background: The initiation of odontogenic tumorigenesis often involves the activation of the MAP-kinase path- way, with a pivotal role played by the BRAF V600E mutation. This study aimed to investigate the frequency of BRAF V600E immunoexpresion in ameloblastomas diagnosed in four Latin American centers and correlate this finding with the histological types and subtypes of the analyzed cases.Material and Methods: A total of 86 samples of ameloblastomas were examined for immunohistochemistry using anti-BRAF V600E antibody. The histopathological features of each case were analyzed. Results: Positivity for anti-BRAF V600E antibody was detected in 65/86 cases (75.6%). BRAF V600E was positive in 38/56 cases (67.9%) of conventional ameloblastomas and in 27/30 cases (90.0%) of unicystic ameloblastomas. A statistically significant difference in BRAF V600E positivity was observed when comparing unicystic ameloblastomas to conventional ameloblastomas (p=0.03). No statistically significant difference in BRAF V600E positivity was observed when comparing histological variants, both for conventional ameloblastomas and unicystic ameloblastomas. Conclusions: This study highlights a high frequency of BRAF V600E immunoreactivity in ameloblastomas among Latin American cases. The prevalence of the BRAF V600E immunoexpresion may suggest the feasibility of utilizing BRAF-targeted therapy for ameloblastomas with this mutation.Submitted by Farias Verónica (verofariasblundell@gmail.com) on 2024-04-24T14:28:22Z No. of bitstreams: 2 license_rdf: 25790 bytes, checksum: 489f03e71d39068f329bdec8798bce58 (MD5) 104317medoral26493.pdf: 1289769 bytes, checksum: a2dc89a02da2aac92a526b3594ba6f1c (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2024-04-24T17:41:42Z (GMT). No. of bitstreams: 2 license_rdf: 25790 bytes, checksum: 489f03e71d39068f329bdec8798bce58 (MD5) 104317medoral26493.pdf: 1289769 bytes, checksum: a2dc89a02da2aac92a526b3594ba6f1c (MD5) Previous issue date: 2024Comisión Sectorial de Investigación Científica - Uruguay; Agencia Nacional de Investigación e Innovación / Sistema Nacional de Investigadores - Uruguay.8 h.application/pdfen_USengMedicina Oral S.LMedicina Oral Patologia Oral y Cirugia Bucal, 2024.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)ImmunohistochemistryOdontogenic tumorsAmeloblastomaFrequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literatureArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaSilveira, Felipe MartinsSchuch, Lauren FrenzelPereira-Prado, VanesaSicco, EstefaníaAlmeda-Ojeda, OscarMolina-Frechero, NellyPaparella, María LuisaVillarroel-Dorrego, MarinaHernández, MarcelaBologna-Molina, RonellLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/43627/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; 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- Universidad de la Repúblicafalse |
| spellingShingle | Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature Silveira, Felipe Martins Immunohistochemistry Odontogenic tumors Ameloblastoma |
| status_str | publishedVersion |
| title | Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature |
| title_full | Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature |
| title_fullStr | Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature |
| title_full_unstemmed | Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature |
| title_short | Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature |
| title_sort | Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature |
| topic | Immunohistochemistry Odontogenic tumors Ameloblastoma |
| url | https://hdl.handle.net/20.500.12008/43627 |
