Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay
Resumen:
Uruguay controlled the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased. Herein, we analyzed the country-wide genetic diversity of SARS-CoV-2 between November 2020 and April 2021. We identified that the most prevalent viral variant during the first epidemic wave in Uruguay (December 2020–February 2021) was a B.1.1.28 sublineage carrying Spike mutations Q675H + Q677H, now designated as P.6, followed by lineages P.2 and P.7. P.6 probably arose around November 2020, in Montevideo, Uruguay’s capital department, and rapidly spread to other departments, with evidence of further local transmission clusters; it also spread sporadically to the USA and Spain. The more efficient dissemination of lineage P.6 with respect to P.2 and P.7 and the presence of mutations (Q675H and Q677H) in the proximity of the key cleavage site at the S1/S2 boundary suggest that P.6 may be more transmissible than other lineages co-circulating in Uruguay. Although P.6 was replaced by the variant of concern (VOC) P.1 as the predominant lineage in Uruguay since April 2021, the monitoring of the concurrent emergence of Q675H + Q677H in VOCs should be of worldwide interest.
| 2021 | |
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SARS-CoV-2 B.1.1.28 Spike Q675H Q677H Phylogeography Phylogenetics |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/41299 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1807522802106892288 |
|---|---|
| author | Rego, Natalia |
| author2 | Salazar González, María Cecilia Paz, Mercedes Costábile Cristech, Alicia Fajardo Rossi, Álvaro Ferrés Cáceres, Ignacio Perbolianachis Duarte, Paula Fernández Calero, Tamara Veronica, Noya Machado, Matías Brandes Lamas, Mariana Sofía Arce Rama, Rodrigo Arleo Capovilla, Mailén Possi, Tania Reyes, Natalia Bentancor, María Noel Lizasoaín Cuelho, Andrés Bortagaray Galluzzo, Viviana Moller, Ana Chappos, Odhille Nin, Nicolás Hurtado, Francisco Javier Duquía, Melissa González, María Belén Griffero Ramilo, Luciana Méndez, Mauricio Techera, María Pía Smircich, Pablo Mir, Daiana Alonso, Cecilia Medina, Julio Albornoz, Henry Colina, Rodney Bello, Gonzalo Moreno Karlen, María del Pilar Moratorio, Gonzalo Iraola, Gregorio Spangenberg, Lucía |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Rego, Natalia Salazar González, María Cecilia Paz, Mercedes Costábile Cristech, Alicia Fajardo Rossi, Álvaro Ferrés Cáceres, Ignacio Perbolianachis Duarte, Paula Fernández Calero, Tamara Veronica, Noya Machado, Matías Brandes Lamas, Mariana Sofía Arce Rama, Rodrigo Arleo Capovilla, Mailén Possi, Tania Reyes, Natalia Bentancor, María Noel Lizasoaín Cuelho, Andrés Bortagaray Galluzzo, Viviana Moller, Ana Chappos, Odhille Nin, Nicolás Hurtado, Francisco Javier Duquía, Melissa González, María Belén Griffero Ramilo, Luciana Méndez, Mauricio Techera, María Pía Smircich, Pablo Mir, Daiana Alonso, Cecilia Medina, Julio Albornoz, Henry Colina, Rodney Bello, Gonzalo Moreno Karlen, María del Pilar Moratorio, Gonzalo Iraola, Gregorio Spangenberg, Lucía |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Rego Natalia, Instituto Pasteur (Montevideo). Salazar González María Cecilia, Instituto Pasteur (Montevideo). Paz Mercedes, Instituto Pasteur (Montevideo). Costábile Cristech Alicia, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Fajardo Rossi Álvaro, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Ferrés Cáceres Ignacio, Instituto Pasteur (Montevideo). Perbolianachis Duarte Paula, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Fernández Calero Tamara, Instituto Pasteur (Montevideo). Veronica Noya, Sanatorio Americano (Uruguay) Machado Matías, Instituto Pasteur (Montevideo). Brandes Lamas Mariana Sofía, Instituto Pasteur (Montevideo). Arce Rama Rodrigo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Arleo Capovilla Mailén, Sanatorio Americano (Uruguay) Possi Tania, Sanatorio Americano (Uruguay) Reyes Natalia, Sanatorio Americano (Uruguay) Bentancor María Noel, Sanatorio Americano (Uruguay) Lizasoaín Cuelho Andrés, Universidad de la República (Uruguay). CENUR Litoral Norte. Bortagaray Galluzzo Viviana, Universidad de la República (Uruguay). CENUR Litoral Norte. Moller Ana, Universidad de la República (Uruguay). CENUR Litoral Norte. Chappos Odhille, Universidad de la República (Uruguay). CURE. Nin Nicolás, Hospital Español (Uruguay) Hurtado Francisco Javier, Hospital Español (Uruguay) Duquía Melissa, Universidad de la República (Uruguay). CURE. González María Belén, Universidad de la República (Uruguay). CURE. Griffero Ramilo Luciana, Universidad de la República (Uruguay). CURE. Méndez Mauricio, Universidad de la República (Uruguay). CURE. Techera María Pía, Universidad de la República (Uruguay). CURE. Smircich Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Mir Daiana, Universidad de la República (Uruguay). CENUR Litoral Norte. Alonso Cecilia, Universidad de la República (Uruguay). CENUR Litoral Norte. Medina Julio, Universidad de la República (Uruguay). Facultad de Medicina. Albornoz Henry, Universidad de la República (Uruguay). Facultad de Medicina. Colina Rodney, Universidad de la República (Uruguay). CENUR Litoral Norte. Bello Gonzalo, Instituto Oswaldo Cruz (Brasil) Moreno Karlen María del Pilar, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Moratorio Gonzalo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Iraola Gregorio, Instituto Pasteur (Montevideo). Spangenberg Lucía, Instituto Pasteur (Montevideo). |
| dc.coverage.spatial.es.fl_str_mv | Uruguay |
| dc.creator.none.fl_str_mv | Rego, Natalia Salazar González, María Cecilia Paz, Mercedes Costábile Cristech, Alicia Fajardo Rossi, Álvaro Ferrés Cáceres, Ignacio Perbolianachis Duarte, Paula Fernández Calero, Tamara Veronica, Noya Machado, Matías Brandes Lamas, Mariana Sofía Arce Rama, Rodrigo Arleo Capovilla, Mailén Possi, Tania Reyes, Natalia Bentancor, María Noel Lizasoaín Cuelho, Andrés Bortagaray Galluzzo, Viviana Moller, Ana Chappos, Odhille Nin, Nicolás Hurtado, Francisco Javier Duquía, Melissa González, María Belén Griffero Ramilo, Luciana Méndez, Mauricio Techera, María Pía Smircich, Pablo Mir, Daiana Alonso, Cecilia Medina, Julio Albornoz, Henry Colina, Rodney Bello, Gonzalo Moreno Karlen, María del Pilar Moratorio, Gonzalo Iraola, Gregorio Spangenberg, Lucía |
| dc.date.accessioned.none.fl_str_mv | 2023-11-17T14:45:23Z |
| dc.date.available.none.fl_str_mv | 2023-11-17T14:45:23Z |
| dc.date.issued.none.fl_str_mv | 2021 |
| dc.description.abstract.none.fl_txt_mv | Uruguay controlled the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased. Herein, we analyzed the country-wide genetic diversity of SARS-CoV-2 between November 2020 and April 2021. We identified that the most prevalent viral variant during the first epidemic wave in Uruguay (December 2020–February 2021) was a B.1.1.28 sublineage carrying Spike mutations Q675H + Q677H, now designated as P.6, followed by lineages P.2 and P.7. P.6 probably arose around November 2020, in Montevideo, Uruguay’s capital department, and rapidly spread to other departments, with evidence of further local transmission clusters; it also spread sporadically to the USA and Spain. The more efficient dissemination of lineage P.6 with respect to P.2 and P.7 and the presence of mutations (Q675H and Q677H) in the proximity of the key cleavage site at the S1/S2 boundary suggest that P.6 may be more transmissible than other lineages co-circulating in Uruguay. Although P.6 was replaced by the variant of concern (VOC) P.1 as the predominant lineage in Uruguay since April 2021, the monitoring of the concurrent emergence of Q675H + Q677H in VOCs should be of worldwide interest. |
| dc.format.extent.es.fl_str_mv | 16 h. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Rego, N, Salazar González, M, Paz, M [y otros autores]. "Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay". Viruses. [en línea] 2021, 13(9): 1801. 16 h. DOI: 10.3390/v13091801. |
| dc.identifier.doi.none.fl_str_mv | 10.3390/v13091801 |
| dc.identifier.issn.none.fl_str_mv | 1999-4915 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/41299 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | MDPI |
| dc.relation.ispartof.es.fl_str_mv | Viruses, 2021, 13(9): 1801. |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | SARS-CoV-2 B.1.1.28 Spike Q675H Q677H Phylogeography Phylogenetics |
| dc.title.none.fl_str_mv | Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Uruguay controlled the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased. Herein, we analyzed the country-wide genetic diversity of SARS-CoV-2 between November 2020 and April 2021. We identified that the most prevalent viral variant during the first epidemic wave in Uruguay (December 2020–February 2021) was a B.1.1.28 sublineage carrying Spike mutations Q675H + Q677H, now designated as P.6, followed by lineages P.2 and P.7. P.6 probably arose around November 2020, in Montevideo, Uruguay’s capital department, and rapidly spread to other departments, with evidence of further local transmission clusters; it also spread sporadically to the USA and Spain. The more efficient dissemination of lineage P.6 with respect to P.2 and P.7 and the presence of mutations (Q675H and Q677H) in the proximity of the key cleavage site at the S1/S2 boundary suggest that P.6 may be more transmissible than other lineages co-circulating in Uruguay. Although P.6 was replaced by the variant of concern (VOC) P.1 as the predominant lineage in Uruguay since April 2021, the monitoring of the concurrent emergence of Q675H + Q677H in VOCs should be of worldwide interest. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_12c24610055d1f00c1244d909beb5f26 |
| identifier_str_mv | Rego, N, Salazar González, M, Paz, M [y otros autores]. "Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay". Viruses. [en línea] 2021, 13(9): 1801. 16 h. DOI: 10.3390/v13091801. 1999-4915 10.3390/v13091801 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/41299 |
| publishDate | 2021 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Rego Natalia, Instituto Pasteur (Montevideo).Salazar González María Cecilia, Instituto Pasteur (Montevideo).Paz Mercedes, Instituto Pasteur (Montevideo).Costábile Cristech Alicia, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Fajardo Rossi Álvaro, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Ferrés Cáceres Ignacio, Instituto Pasteur (Montevideo).Perbolianachis Duarte Paula, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Fernández Calero Tamara, Instituto Pasteur (Montevideo).Veronica Noya, Sanatorio Americano (Uruguay)Machado Matías, Instituto Pasteur (Montevideo).Brandes Lamas Mariana Sofía, Instituto Pasteur (Montevideo).Arce Rama Rodrigo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Arleo Capovilla Mailén, Sanatorio Americano (Uruguay)Possi Tania, Sanatorio Americano (Uruguay)Reyes Natalia, Sanatorio Americano (Uruguay)Bentancor María Noel, Sanatorio Americano (Uruguay)Lizasoaín Cuelho Andrés, Universidad de la República (Uruguay). CENUR Litoral Norte.Bortagaray Galluzzo Viviana, Universidad de la República (Uruguay). CENUR Litoral Norte.Moller Ana, Universidad de la República (Uruguay). CENUR Litoral Norte.Chappos Odhille, Universidad de la República (Uruguay). CURE.Nin Nicolás, Hospital Español (Uruguay)Hurtado Francisco Javier, Hospital Español (Uruguay)Duquía Melissa, Universidad de la República (Uruguay). CURE.González María Belén, Universidad de la República (Uruguay). CURE.Griffero Ramilo Luciana, Universidad de la República (Uruguay). CURE.Méndez Mauricio, Universidad de la República (Uruguay). CURE.Techera María Pía, Universidad de la República (Uruguay). CURE.Smircich Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Mir Daiana, Universidad de la República (Uruguay). CENUR Litoral Norte.Alonso Cecilia, Universidad de la República (Uruguay). CENUR Litoral Norte.Medina Julio, Universidad de la República (Uruguay). Facultad de Medicina.Albornoz Henry, Universidad de la República (Uruguay). Facultad de Medicina.Colina Rodney, Universidad de la República (Uruguay). CENUR Litoral Norte.Bello Gonzalo, Instituto Oswaldo Cruz (Brasil)Moreno Karlen María del Pilar, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Moratorio Gonzalo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Iraola Gregorio, Instituto Pasteur (Montevideo).Spangenberg Lucía, Instituto Pasteur (Montevideo).Uruguay2023-11-17T14:45:23Z2023-11-17T14:45:23Z2021Rego, N, Salazar González, M, Paz, M [y otros autores]. "Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay". Viruses. [en línea] 2021, 13(9): 1801. 16 h. DOI: 10.3390/v13091801.1999-4915https://hdl.handle.net/20.500.12008/4129910.3390/v13091801Uruguay controlled the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased. Herein, we analyzed the country-wide genetic diversity of SARS-CoV-2 between November 2020 and April 2021. We identified that the most prevalent viral variant during the first epidemic wave in Uruguay (December 2020–February 2021) was a B.1.1.28 sublineage carrying Spike mutations Q675H + Q677H, now designated as P.6, followed by lineages P.2 and P.7. P.6 probably arose around November 2020, in Montevideo, Uruguay’s capital department, and rapidly spread to other departments, with evidence of further local transmission clusters; it also spread sporadically to the USA and Spain. The more efficient dissemination of lineage P.6 with respect to P.2 and P.7 and the presence of mutations (Q675H and Q677H) in the proximity of the key cleavage site at the S1/S2 boundary suggest that P.6 may be more transmissible than other lineages co-circulating in Uruguay. Although P.6 was replaced by the variant of concern (VOC) P.1 as the predominant lineage in Uruguay since April 2021, the monitoring of the concurrent emergence of Q675H + Q677H in VOCs should be of worldwide interest.Submitted by Parodi Mónica (mparodi@fcien.edu.uy) on 2023-11-16T18:01:43Z No. of bitstreams: 2 license_rdf: 24251 bytes, checksum: 71ed42ef0a0b648670f707320be37b90 (MD5) 103390v13091801.pdf: 1774823 bytes, checksum: 90901a8c72309c584764b697467938b7 (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2023-11-17T14:44:21Z (GMT) No. of bitstreams: 2 license_rdf: 24251 bytes, checksum: 71ed42ef0a0b648670f707320be37b90 (MD5) 103390v13091801.pdf: 1774823 bytes, checksum: 90901a8c72309c584764b697467938b7 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2023-11-17T14:45:23Z (GMT). No. of bitstreams: 2 license_rdf: 24251 bytes, checksum: 71ed42ef0a0b648670f707320be37b90 (MD5) 103390v13091801.pdf: 1774823 bytes, checksum: 90901a8c72309c584764b697467938b7 (MD5) Previous issue date: 202116 h.application/pdfenengMDPIViruses, 2021, 13(9): 1801.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)SARS-CoV-2B.1.1.28SpikeQ675HQ677HPhylogeographyPhylogeneticsEmergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in UruguayArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaRego, NataliaSalazar González, María CeciliaPaz, MercedesCostábile Cristech, AliciaFajardo Rossi, ÁlvaroFerrés Cáceres, IgnacioPerbolianachis Duarte, PaulaFernández Calero, TamaraVeronica, NoyaMachado, MatíasBrandes Lamas, Mariana SofíaArce Rama, RodrigoArleo Capovilla, MailénPossi, TaniaReyes, NataliaBentancor, María NoelLizasoaín Cuelho, AndrésBortagaray Galluzzo, VivianaMoller, AnaChappos, OdhilleNin, NicolásHurtado, Francisco JavierDuquía, MelissaGonzález, María BelénGriffero Ramilo, LucianaMéndez, MauricioTechera, María PíaSmircich, PabloMir, DaianaAlonso, CeciliaMedina, JulioAlbornoz, HenryColina, RodneyBello, GonzaloMoreno Karlen, María del PilarMoratorio, GonzaloIraola, GregorioSpangenberg, LucíaLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/41299/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-844http://localhost:8080/xmlui/bitstream/20.500.12008/41299/2/license_urla0ebbeafb9d2ec7cbb19d7137ebc392cMD52license_textlicense_texttext/html; charset=utf-813786http://localhost:8080/xmlui/bitstream/20.500.12008/41299/3/license_text9b2f65dcc322aef148d393163faed91bMD53license_rdflicense_rdfapplication/rdf+xml; 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- Universidad de la Repúblicafalse |
| spellingShingle | Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay Rego, Natalia SARS-CoV-2 B.1.1.28 Spike Q675H Q677H Phylogeography Phylogenetics |
| status_str | publishedVersion |
| title | Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay |
| title_full | Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay |
| title_fullStr | Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay |
| title_full_unstemmed | Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay |
| title_short | Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay |
| title_sort | Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay |
| topic | SARS-CoV-2 B.1.1.28 Spike Q675H Q677H Phylogeography Phylogenetics |
| url | https://hdl.handle.net/20.500.12008/41299 |
