A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents
Resumen:
Antimalarial drugs based on quinolines have been widely used as leishmanicidal agents for either cutaneous or visceral leishmaniasis models. Herein, we showed the leishmanicidal response against in vitro models of different Leishmania spp. and against in vivo models of eleven key antimalarials, including chloroquine, sitamaquine, amodiaquine, mefloquine, quinine, primaquine, hydroxychloroquine, tafenoquine, quinacrine and moxipraquine. Mechanistic studies and advances in clinical treatment are also discussed. This mini-review aims to show the state of the art in using antimalarial drugs to discover alternative therapies for leishmaniasis treatment.
| 2025 | |
| ANII: SNI_2023_1_1013178 | |
|
Quinoline derivatives Antimalarials Leishmaniasis Drugs repurposing Antiprotozoal activity |
|
| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/54535 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1877555239476789248 |
|---|---|
| author | Avanzo, Romina E. |
| author2 | García Liñares, Guadalupe Rodríguez, Noris Romero Cordero, Ángel Heriberto |
| author2_role | author author author |
| author_facet | Avanzo, Romina E. García Liñares, Guadalupe Rodríguez, Noris Romero Cordero, Ángel Heriberto |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Avanzo Romina E. García Liñares Guadalupe Rodríguez Noris Romero Cordero Ángel Heriberto, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. |
| dc.creator.none.fl_str_mv | Avanzo, Romina E. García Liñares, Guadalupe Rodríguez, Noris Romero Cordero, Ángel Heriberto |
| dc.date.accessioned.none.fl_str_mv | 2026-04-22T13:01:14Z |
| dc.date.available.none.fl_str_mv | 2026-04-22T13:01:14Z |
| dc.date.issued.none.fl_str_mv | 2025 |
| dc.description.abstract.none.fl_txt_mv | Antimalarial drugs based on quinolines have been widely used as leishmanicidal agents for either cutaneous or visceral leishmaniasis models. Herein, we showed the leishmanicidal response against in vitro models of different Leishmania spp. and against in vivo models of eleven key antimalarials, including chloroquine, sitamaquine, amodiaquine, mefloquine, quinine, primaquine, hydroxychloroquine, tafenoquine, quinacrine and moxipraquine. Mechanistic studies and advances in clinical treatment are also discussed. This mini-review aims to show the state of the art in using antimalarial drugs to discover alternative therapies for leishmaniasis treatment. |
| dc.description.sponsorship.none.fl_txt_mv | ANII: SNI_2023_1_1013178 |
| dc.format.extent.es.fl_str_mv | 10 h |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Avanzo, R, García Liñares, G, Rodríguez, N [y otro autor]. "A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents". Frontiers in Chemistry. [en línea] 2025, 13: 1608340. 10 h. DOI: 10.3389/fchem.2025.1608340 |
| dc.identifier.doi.none.fl_str_mv | 10.3389/fchem.2025.1608340 |
| dc.identifier.issn.none.fl_str_mv | 2296-2646 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/54535 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Frontiers |
| dc.relation.none.fl_str_mv | Frontiers in Chemistry, 2025, 13: 1608340. |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Quinoline derivatives Antimalarials Leishmaniasis Drugs repurposing Antiprotozoal activity |
| dc.title.none.fl_str_mv | A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Antimalarial drugs based on quinolines have been widely used as leishmanicidal agents for either cutaneous or visceral leishmaniasis models. Herein, we showed the leishmanicidal response against in vitro models of different Leishmania spp. and against in vivo models of eleven key antimalarials, including chloroquine, sitamaquine, amodiaquine, mefloquine, quinine, primaquine, hydroxychloroquine, tafenoquine, quinacrine and moxipraquine. Mechanistic studies and advances in clinical treatment are also discussed. This mini-review aims to show the state of the art in using antimalarial drugs to discover alternative therapies for leishmaniasis treatment. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_0eb491a47e37209fac4ef5aafbacfb84 |
| identifier_str_mv | Avanzo, R, García Liñares, G, Rodríguez, N [y otro autor]. "A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents". Frontiers in Chemistry. [en línea] 2025, 13: 1608340. 10 h. DOI: 10.3389/fchem.2025.1608340 2296-2646 10.3389/fchem.2025.1608340 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/54535 |
| publishDate | 2025 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | karina.camps@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Avanzo Romina E.García Liñares GuadalupeRodríguez NorisRomero Cordero Ángel Heriberto, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.2026-04-22T13:01:14Z2026-04-22T13:01:14Z2025Avanzo, R, García Liñares, G, Rodríguez, N [y otro autor]. "A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents". Frontiers in Chemistry. [en línea] 2025, 13: 1608340. 10 h. DOI: 10.3389/fchem.2025.16083402296-2646https://hdl.handle.net/20.500.12008/5453510.3389/fchem.2025.1608340Antimalarial drugs based on quinolines have been widely used as leishmanicidal agents for either cutaneous or visceral leishmaniasis models. Herein, we showed the leishmanicidal response against in vitro models of different Leishmania spp. and against in vivo models of eleven key antimalarials, including chloroquine, sitamaquine, amodiaquine, mefloquine, quinine, primaquine, hydroxychloroquine, tafenoquine, quinacrine and moxipraquine. Mechanistic studies and advances in clinical treatment are also discussed. This mini-review aims to show the state of the art in using antimalarial drugs to discover alternative therapies for leishmaniasis treatment.Submitted by Pintos Natalia (nataliapintosmvd@gmail.com) on 2026-04-20T12:30:00Z No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) 10.3389.fchem.2025.1608340.pdf: 890551 bytes, checksum: f45fcca87454b1d8163d3be0cc2491f0 (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2026-04-21T17:58:10Z (GMT) No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) 10.3389.fchem.2025.1608340.pdf: 890551 bytes, checksum: f45fcca87454b1d8163d3be0cc2491f0 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2026-04-22T13:01:14Z (GMT). No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) 10.3389.fchem.2025.1608340.pdf: 890551 bytes, checksum: f45fcca87454b1d8163d3be0cc2491f0 (MD5) Previous issue date: 2025ANII: SNI_2023_1_101317810 happlication/pdfenengFrontiersFrontiers in Chemistry, 2025, 13: 1608340.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Quinoline derivativesAntimalarialsLeishmaniasisDrugs repurposingAntiprotozoal activityA comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agentsArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaAvanzo, Romina E.García Liñares, GuadalupeRodríguez, NorisRomero Cordero, Ángel HeribertoLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/54535/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-844http://localhost:8080/xmlui/bitstream/20.500.12008/54535/2/license_urla0ebbeafb9d2ec7cbb19d7137ebc392cMD52license_textlicense_texttext/html; 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| spellingShingle | A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents Avanzo, Romina E. Quinoline derivatives Antimalarials Leishmaniasis Drugs repurposing Antiprotozoal activity |
| status_str | publishedVersion |
| title | A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents |
| title_full | A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents |
| title_fullStr | A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents |
| title_full_unstemmed | A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents |
| title_short | A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents |
| title_sort | A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents |
| topic | Quinoline derivatives Antimalarials Leishmaniasis Drugs repurposing Antiprotozoal activity |
| url | https://hdl.handle.net/20.500.12008/54535 |
