Sea level is rising worldwide with local differences due to global and regional drivers. This article analyses yearly freshwater and sea level trends and fluctuations during the mixing of fresh- and sea-water along the Uruguayan coast of the Rio de la Plata River estuary and the Atlantic coast from 1961 to 2014. The global and regional drivers as well as local co-variables are described, classified in nine discrete classes and inter-correlated. Despite the observed increasing trends, local sea level rises (SLR) are not well correlated with global SLR except at the estuarine-ocean boundary (Punta del Este station). Freshwater inflow, which variability often coincides with Oceanic El Niño-La Niña (ONI-ENSO) events, is the first descriptor of sea level fluctuations and outliers all along the coast, particularly at Punta del Este. Local SLR roughly follows the overall global trend with periods of acceleration and stabilization often coinciding with ENSO events