The main objective of this work was to study the structural viability of using small-diameter logs of Uruguayan Loblolly/Slash pine, mainly from thinning operations, to design cross-laminated timber (CLT) panels. A visual grade named “CTH” (coniferous thinning) was proposed, and 45 specimens of sawn timber boards were tested, resulting in 51% lower bending strength than that of the minimum strength class C14. Subsequently, 20 CLT panels were manufactured and experimentally tested, the results showed that the bending strength of the CLT panels was 43% above that of the individual layers. Additionally, the structural performance of the CLT panels for use in floors was calculated, and the thickness-span relationship depending on strength class and imposed load are presented. Results showed than the use of CTH timber to design CLT floors implies a volume (m3/m2) 17% higher than that using C24 timber.