Weighted single-step genomic BLUP: an iterative approach for accurate calculation of GEBV and GWAS.
- Autor(es):
- ZHANG, X. ; LOURENCO, D. ; MISZTAL, I. ; AGUILAR, I. ; LEGARRA, A.
- Tipo:
- Conferencia
- Versión:
- Publicado
- Resumen:
-
ABSTRACT.Three different procedures were implemented to calculate weights for a genomic relationship matrix to restrict the shrinkage along iterations of weighted single-step genomic BLUP (WssGBLUP). The procedures as well as BayesC were tested with 3 simulated data sets. Prediction accuracy for WssGBLUP improved at 2nd or 3rd iteration by updating only the top number of SNP equal to 1 × or 3 × the number of QTL; accuracy increased after 3rd iteration and remained stable by using weights proportional to 2pi(1- pi)ui2+ constant. Except in the 5 QTL scenario, accuracies with all WssGBLUP procedures were higher than with BayesC. Noise in Manhattan plots was small with 5 and 100 QTL but large with 500 QTL.
- Año:
- 2014
- Idioma:
- Inglés
- Temas:
- GWAS
WssGBLUP
- Institución:
- Instituto Nacional de Investigación Agropecuaria
- Repositorio:
- Ainfo
- Enlace(s):
- http://www.ainfo.inia.uy/consulta/busca?b=pc&id=61922&biblioteca=vazio&busca=61922&qFacets=61922
- Nivel de acceso:
- Acceso abierto
